dc.date.accessioned | 2021-06-25T15:57:42Z | |
dc.date.available | 2021-06-25T15:57:42Z | |
dc.date.created | 2021-06-21T15:08:53Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Oppen, Kjersti Ueland, Thor Siljan, William Ward Skadberg, Øyvind Brede, Cato Lauritzen, Trine Aukrust, Pål Steinsvik, Trude Husebye, Einar Michelsen, Annika Holter, Jan Cato Heggelund, Lars . Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia. Open Forum Infectious Diseases. 2021, 8(4) | |
dc.identifier.uri | http://hdl.handle.net/10852/86469 | |
dc.description.abstract | Abstract
Background
Iron is crucial for survival and growth of microbes. Consequently, limiting iron availability is a human antimicrobial defense mechanism. We explored iron and iron-related proteins as potential biomarkers in community-acquired pneumonia and hypothesized that infection-induced changes in these potential biomarkers differ between groups of pathogens and could predict microbial etiology.
Methods
Blood samples from a prospective cohort of 267 patients with community-acquired pneumonia were analyzed for hepcidin, ferritin, iron, transferrin, and soluble transferrin receptor at admission, clinical stabilization, and a 6-week follow-up. A total of 111 patients with an established microbiological diagnosis confined to 1 microbial group (atypical bacterial, typical bacterial, or viral) were included in predictive analyses.
Results
High admission levels of ferritin predicted atypical bacterial versus typical bacterial etiology (odds ratio [OR], 2.26; 95% confidence interval [CI], 1.18–4.32; P = .014). Furthermore, hepcidin and ferritin predicted atypical bacterial versus viral etiology (hepcidin: OR = 3.12, 95% CI = 1.34–7.28, P = .008; ferritin: OR = 2.38, 95% CI = 1.28–4.45, P = .006). The findings were independent of C-reactive protein and procalcitonin.
Conclusions
Hepcidin and ferritin are potential biomarkers of microbial etiology in community-acquired pneumonia. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Hepcidin and ferritin predict microbial etiology in community-acquired pneumonia | |
dc.type | Journal article | |
dc.creator.author | Oppen, Kjersti | |
dc.creator.author | Ueland, Thor | |
dc.creator.author | Siljan, William Ward | |
dc.creator.author | Skadberg, Øyvind | |
dc.creator.author | Brede, Cato | |
dc.creator.author | Lauritzen, Trine | |
dc.creator.author | Aukrust, Pål | |
dc.creator.author | Steinsvik, Trude | |
dc.creator.author | Husebye, Einar | |
dc.creator.author | Michelsen, Annika | |
dc.creator.author | Holter, Jan Cato | |
dc.creator.author | Heggelund, Lars | |
cristin.unitcode | 185,53,0,0 | |
cristin.unitname | Institutt for klinisk medisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1917382 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Open Forum Infectious Diseases&rft.volume=8&rft.spage=&rft.date=2021 | |
dc.identifier.jtitle | Open Forum Infectious Diseases | |
dc.identifier.volume | 8 | |
dc.identifier.issue | 4 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1093/ofid/ofab082 | |
dc.identifier.urn | URN:NBN:no-89104 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2328-8957 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/86469/2/ofab082.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | ofab082 | |