A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
dc.date.accessioned | 2021-04-26T20:13:17Z | |
dc.date.available | 2021-04-26T20:13:17Z | |
dc.date.created | 2021-03-08T11:21:49Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Escala-Garcia, Maria Abraham, Jean Andrulis, Irene L. Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L. Auvinen, Päivi Beckmann, Matthias W. Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V. Bojesen, Stig Egil Bolla, Manjeet K. Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Yvonne Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J. Chin, Suet-Feung Clarke, Christine L. Couch, Fergus Joseph Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B. Dennis, Joe Devilee, Peter Dunn, Janet A. Dunning, Alison M Dwek, Miriam Kristensen, Vessela N. Lambrechts, Diether Lindblom, Annika Lubiński, Jan Schwentner, Lukas Scott, Christopher Tapper, William J. Winqvist, Robert Bader, Gary D. Dork, Thilo Easton, Douglas F. Canisius, Sander Schmidt, Marjanka K. . A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Nature Communications. 2020, 11:312, 1-14 | |
dc.identifier.uri | http://hdl.handle.net/10852/85643 | |
dc.description.abstract | Abstract Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A network analysis to identify mediators of germline-driven differences in breast cancer prognosis | |
dc.type | Journal article | |
dc.creator.author | Escala-Garcia, Maria | |
dc.creator.author | Abraham, Jean | |
dc.creator.author | Andrulis, Irene L. | |
dc.creator.author | Anton-Culver, Hoda | |
dc.creator.author | Arndt, Volker | |
dc.creator.author | Ashworth, Alan | |
dc.creator.author | Auer, Paul L. | |
dc.creator.author | Auvinen, Päivi | |
dc.creator.author | Beckmann, Matthias W. | |
dc.creator.author | Beesley, Jonathan | |
dc.creator.author | Behrens, Sabine | |
dc.creator.author | Benitez, Javier | |
dc.creator.author | Bermisheva, Marina | |
dc.creator.author | Blomqvist, Carl | |
dc.creator.author | Blot, William | |
dc.creator.author | Bogdanova, Natalia V. | |
dc.creator.author | Bojesen, Stig Egil | |
dc.creator.author | Bolla, Manjeet K. | |
dc.creator.author | Børresen-Dale, Anne-Lise | |
dc.creator.author | Brauch, Hiltrud | |
dc.creator.author | Brenner, Hermann | |
dc.creator.author | Brucker, Sara Yvonne | |
dc.creator.author | Burwinkel, Barbara | |
dc.creator.author | Caldas, Carlos | |
dc.creator.author | Canzian, Federico | |
dc.creator.author | Chang-Claude, Jenny | |
dc.creator.author | Chanock, Stephen J. | |
dc.creator.author | Chin, Suet-Feung | |
dc.creator.author | Clarke, Christine L. | |
dc.creator.author | Couch, Fergus Joseph | |
dc.creator.author | Cox, Angela | |
dc.creator.author | Cross, Simon S | |
dc.creator.author | Czene, Kamila | |
dc.creator.author | Daly, Mary B. | |
dc.creator.author | Dennis, Joe | |
dc.creator.author | Devilee, Peter | |
dc.creator.author | Dunn, Janet A. | |
dc.creator.author | Dunning, Alison M | |
dc.creator.author | Dwek, Miriam | |
dc.creator.author | Kristensen, Vessela N. | |
dc.creator.author | Lambrechts, Diether | |
dc.creator.author | Lindblom, Annika | |
dc.creator.author | Lubiński, Jan | |
dc.creator.author | Schwentner, Lukas | |
dc.creator.author | Scott, Christopher | |
dc.creator.author | Tapper, William J. | |
dc.creator.author | Winqvist, Robert | |
dc.creator.author | Bader, Gary D. | |
dc.creator.author | Dork, Thilo | |
dc.creator.author | Easton, Douglas F. | |
dc.creator.author | Canisius, Sander | |
dc.creator.author | Schmidt, Marjanka K. | |
cristin.unitcode | 185,53,18,10 | |
cristin.unitname | Avdeling for medisinsk genetikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1896294 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=11:312&rft.spage=1&rft.date=2020 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 11 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-019-14100-6 | |
dc.identifier.urn | URN:NBN:no-88294 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85643/2/Postnr%2B1896294_Escala-Garcia%2Bet%2Bal_Nat%2BCommun_s41467-019-14100-6.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 312 | |
dc.relation.project | NFR/193387 |
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