dc.date.accessioned | 2020-09-30T18:21:41Z | |
dc.date.available | 2020-09-30T18:21:41Z | |
dc.date.created | 2020-07-31T11:37:19Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Hjell, Gabriela Mørch-Johnsen, Lynn Holst, René Tesli, Natalia Bell, Christina Lunding, Synve Hoffart Rødevand, Linn Nilsen Werner, Maren Caroline Frogner Melle, Ingrid Andreassen, Ole Andreas Lagerberg, Trine Vik Steen, Nils Eiel Haukvik, Unn Kristin H. . Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior. 2020 | |
dc.identifier.uri | http://hdl.handle.net/10852/80177 | |
dc.description.abstract | Objective
Low total cholesterol has been linked with adverse mental symptoms such as aggression and impulsivity in severe mental disorders (SMDs). This putative association may affect the clinician's decision making about cholesterol lowering in this patient group. Here, we investigated the associations between cholesterol levels, aggression, and impulsivity in a large representative sample of in‐ and outpatients with SMD.
Methods
Patients with schizophrenia‐ or bipolar spectrum disorders (N = 1 001) underwent thorough clinical characterization and blood sampling (total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol). Aggression was characterized by the Positive and Negative Syndrome Scale Excited Component. Impulsivity was measured with the Barratt Impulsiveness Scale in a subsample of patients (N = 288). We used a multinomial logistic regression model to analyze the association between cholesterol and aggression and a multiple linear regression model to analyze the association between cholesterol and impulsivity, while controlling for confounders.
Results
We found no significant associations between cholesterol levels and aggression or impulsivity. There were no significant interactions between cholesterol and diagnostic group or inpatient versus outpatient status. Controlling for medication use, body mass index, alcohol or illicit substance use did not affect the results.
Conclusion
In this large sample of patients with schizophrenia‐ and bipolar spectrum disorders, we found no associations between cholesterol levels and aggression or impulsivity. This has clinical implications as patients with SMD are at increased CVD risk and currently undertreated with statins. | en_US |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Hjell, Gabriela | |
dc.creator.author | Mørch-Johnsen, Lynn | |
dc.creator.author | Holst, René | |
dc.creator.author | Tesli, Natalia | |
dc.creator.author | Bell, Christina | |
dc.creator.author | Lunding, Synve Hoffart | |
dc.creator.author | Rødevand, Linn Nilsen | |
dc.creator.author | Werner, Maren Caroline Frogner | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Andreassen, Ole Andreas | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Steen, Nils Eiel | |
dc.creator.author | Haukvik, Unn Kristin H. | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1821121 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain and Behavior&rft.volume=&rft.spage=&rft.date=2020 | |
dc.identifier.jtitle | Brain and Behavior | |
dc.identifier.volume | 10 | |
dc.identifier.issue | 9 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1002/brb3.1751 | |
dc.identifier.urn | URN:NBN:no-83284 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2162-3279 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/80177/1/Disentangling%2Bthe%2Brelationship%2Bbetween%2Bcholesterol%252C%2Baggression%252C%2Band%2Bimpulsivity%2Bin%2Bsevere%2Bmental%2Bdisorders.pdf | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/223273 | |