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dc.date.accessioned2020-07-10T19:46:27Z
dc.date.available2020-07-10T19:46:27Z
dc.date.created2019-05-02T08:15:30Z
dc.date.issued2019
dc.identifier.citationMunkhaugen, John Vethe, Nils Tore Fagerland, Morten Dammen, Toril Perk, Joep Gjertsen, Erik Otterstad, Jan Erik Gullestad, Lars Bergan, Stein Husebye, Einar . Statin-associated muscle symptoms in coronary patients: design of a randomized study. Scandinavian Cardiovascular Journal. 2019, 53(3), 162-168
dc.identifier.urihttp://hdl.handle.net/10852/77799
dc.description.abstractObjectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients with subjective statin-associated muscle symptoms (SAMS) and to determine the association with blood levels of atorvastatin and its metabolites, to obtain an objective marker for true SAMS. Design. A randomized, double-blinded, cross-over study will include 80 coronary patients with subjectively reported SAMS during ongoing atorvastatin therapy or previous muscle symptoms that led to discontinuation of atorvastatin. Patients will be randomized to 7-weeks treatment with atorvastatin 40 mg/day in the first period and matched placebo in the second 7-weeks period, or placebo in the first period and atorvastatin in the second period. Each period is preceded by 1-week wash-out. A control group (n = 40) without muscle symptoms will have 7 weeks open treatment with atorvastatin 40 mg/day. Blood samples will be collected at baseline and at the end of each treatment period, and muscular symptoms will be rated by the patients weekly using a Visual Analogue Scale (VAS). The primary outcome is the difference in aggregated mean VAS scores between the last three weeks of atorvastatin treatment and of placebo treatment. The main purpose is to develop an objective marker for true SAMS, by comparing SAMS associated with blinded atorvastatin treatment with blood concentrations of atorvastatin and its metabolites. Diagnostic and discrimination performance will be determined. Conclusions. The study provides new knowledge on SAMS in coronary patients and may contribute to more personalized statin treatment and monitoring, fewer side-effects and consequently improved adherence and lipid management in future practice.
dc.languageEN
dc.titleStatin-associated muscle symptoms in coronary patients: design of a randomized study
dc.typeJournal article
dc.creator.authorMunkhaugen, John
dc.creator.authorVethe, Nils Tore
dc.creator.authorFagerland, Morten
dc.creator.authorDammen, Toril
dc.creator.authorPerk, Joep
dc.creator.authorGjertsen, Erik
dc.creator.authorOtterstad, Jan Erik
dc.creator.authorGullestad, Lars
dc.creator.authorBergan, Stein
dc.creator.authorHusebye, Einar
cristin.unitcode185,51,14,0
cristin.unitnameAvdeling for medisinsk atferdsvitenskap
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1694992
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scandinavian Cardiovascular Journal&rft.volume=53&rft.spage=162&rft.date=2019
dc.identifier.jtitleScandinavian Cardiovascular Journal
dc.identifier.volume53
dc.identifier.issue3
dc.identifier.startpage162
dc.identifier.endpage168
dc.identifier.doihttps://doi.org/10.1080/14017431.2019.1612085
dc.identifier.urnURN:NBN:no-80858
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1401-7431
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/77799/4/MUSE_RCT_Trial_Design_Manuscript_Figure_Tables.pdf
dc.type.versionAcceptedVersion


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