dc.date.accessioned | 2020-04-04T18:33:53Z | |
dc.date.available | 2020-04-04T18:33:53Z | |
dc.date.created | 2019-06-28T09:09:33Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Johansson, Henrik J. Socciarelli, Fabio Vacanti, Nathaniel M. Haugen, Mads Haugland Zhu, Yafeng Siavelis, Ioannis Fernandez-Woodbridge, Alejandro Aure, Miriam Ragle Sennblad, Bengt Vesterlund, Mattias Branca, Rui M. Orre, Lukas M. Huss, Mikael Fredlund, Erik Beraki, Else Garred, Øystein Boekel, Jorrit Sauer, Torill Zhao, Wei Nord, Silje Höglander, Elen K. Jans, Daniel C. Brismar, Hjalmar Haukaas, Tonje Husby Bathen, Tone Frost Schlichting, Ellen Naume, Bjørn Luders, Torben Borgen, Elin Kristensen, Vessela N. Russnes, Hege Elisabeth Giercksky Lingjærde, Ole Christian Mills, Gordon B. Sahlberg, Kristine Kleivi Børresen-Dale, Anne-Lise Lehtiö, Janne . Breast cancer quantitative proteome and proteogenomic landscape. Nature Communications. 2019, 10 | |
dc.identifier.uri | http://hdl.handle.net/10852/74375 | |
dc.description.abstract | In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Proteome-based networks distinguish functional protein modules for breast tumor groups, with co-expression of EGFR and MET marking ductal carcinoma in situ regions of normal-like tumors and lending to a more accurate classification of this poorly defined subtype. Genes included within prognostic mRNA panels have significantly higher than average mRNA-protein correlations, and gene copy number alterations are dampened at the protein-level; underscoring the value of proteome quantification for prognostication and phenotypic classification. Furthermore, protein products mapping to non-coding genomic regions are identified; highlighting a potential new class of tumor-specific immunotherapeutic targets. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Breast cancer quantitative proteome and proteogenomic landscape | |
dc.type | Journal article | |
dc.creator.author | Johansson, Henrik J. | |
dc.creator.author | Socciarelli, Fabio | |
dc.creator.author | Vacanti, Nathaniel M. | |
dc.creator.author | Haugen, Mads Haugland | |
dc.creator.author | Zhu, Yafeng | |
dc.creator.author | Siavelis, Ioannis | |
dc.creator.author | Fernandez-Woodbridge, Alejandro | |
dc.creator.author | Aure, Miriam Ragle | |
dc.creator.author | Sennblad, Bengt | |
dc.creator.author | Vesterlund, Mattias | |
dc.creator.author | Branca, Rui M. | |
dc.creator.author | Orre, Lukas M. | |
dc.creator.author | Huss, Mikael | |
dc.creator.author | Fredlund, Erik | |
dc.creator.author | Beraki, Else | |
dc.creator.author | Garred, Øystein | |
dc.creator.author | Boekel, Jorrit | |
dc.creator.author | Sauer, Torill | |
dc.creator.author | Zhao, Wei | |
dc.creator.author | Nord, Silje | |
dc.creator.author | Höglander, Elen K. | |
dc.creator.author | Jans, Daniel C. | |
dc.creator.author | Brismar, Hjalmar | |
dc.creator.author | Haukaas, Tonje Husby | |
dc.creator.author | Bathen, Tone Frost | |
dc.creator.author | Schlichting, Ellen | |
dc.creator.author | Naume, Bjørn | |
dc.creator.author | Luders, Torben | |
dc.creator.author | Borgen, Elin | |
dc.creator.author | Kristensen, Vessela N. | |
dc.creator.author | Russnes, Hege Elisabeth Giercksky | |
dc.creator.author | Lingjærde, Ole Christian | |
dc.creator.author | Mills, Gordon B. | |
dc.creator.author | Sahlberg, Kristine Kleivi | |
dc.creator.author | Børresen-Dale, Anne-Lise | |
dc.creator.author | Lehtiö, Janne | |
cristin.unitcode | 185,53,82,0 | |
cristin.unitname | Klinikk for indremedisin og laboratoriefag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1708511 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=10&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 10 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-019-09018-y | |
dc.identifier.urn | URN:NBN:no-77476 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/74375/1/Johansson.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 1600 | |