dc.contributor.author | Otterdal, Kari | |
dc.contributor.author | Berg, Aase | |
dc.contributor.author | Michelsen, Annika E | |
dc.contributor.author | Patel, Sam | |
dc.contributor.author | Gregersen, Ida | |
dc.contributor.author | Sagen, Ellen L | |
dc.contributor.author | Halvorsen, Bente | |
dc.contributor.author | Yndestad, Arne | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Langeland, Nina | |
dc.contributor.author | Aukrust, Pål | |
dc.date.accessioned | 2020-01-28T06:03:07Z | |
dc.date.available | 2020-01-28T06:03:07Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | BMC Infectious Diseases. 2020 Jan 21;20(1):65 | |
dc.identifier.uri | http://hdl.handle.net/10852/72557 | |
dc.description.abstract | Background
The immune response during falciparum malaria mediates both harmful and protective effects on the host; however the participating molecules have not been fully defined. Interleukin (IL)-27 is a pleiotropic cytokine exerting both inflammatory and anti-inflammatory effects, but data on IL-27 in malaria patients are scarce.
Methods
Clinical data and blood samples were collected from adults in Mozambique with P. falciparum infection, with (n = 70) and without (n = 61) HIV-1 co-infection, from HIV-infected patients with similar symptoms without malaria (n = 58) and from healthy controls (n = 52). In vitro studies were performed in endothelial cells and PBMC using hemozoin crystals. Samples were analyzed using enzyme immunoassays and quantitative PCR.
Results
(i) IL-27 was markedly up-regulated in malaria patients compared with controls and HIV-infected patients without malaria, showing no relation to HIV co-infection. (ii) IL-27 was correlated with P. falciparum parasitemia and von Willebrand factor as a marker of endothelial activation, but not with disease severity. (iii) In vitro, IL-27 modulated the hemozoin-mediated cytokine response in endothelial cells and PBMC with enhancing effects on IL-6 and attenuating effects on IL-8.
Conclusion
Our findings show that IL-27 is regulated during falciparum malaria, mediating both inflammatory and anti-inflammatory effects, potentially playing an immune-regulatory role during falciparum malaria. | |
dc.language.iso | eng | |
dc.rights | The Author(s). | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria | |
dc.type | Journal article | |
dc.date.updated | 2020-01-28T06:03:07Z | |
dc.creator.author | Otterdal, Kari | |
dc.creator.author | Berg, Aase | |
dc.creator.author | Michelsen, Annika E | |
dc.creator.author | Patel, Sam | |
dc.creator.author | Gregersen, Ida | |
dc.creator.author | Sagen, Ellen L | |
dc.creator.author | Halvorsen, Bente | |
dc.creator.author | Yndestad, Arne | |
dc.creator.author | Ueland, Thor | |
dc.creator.author | Langeland, Nina | |
dc.creator.author | Aukrust, Pål | |
dc.identifier.cristin | 1813027 | |
dc.identifier.doi | https://doi.org/10.1186/s12879-020-4783-8 | |
dc.identifier.urn | URN:NBN:no-75682 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/72557/1/12879_2020_Article_4783.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 65 | |