We have previously shown that plasmablasts of the G1m1 allotype of IgG1 areselectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygouspatients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotypein the intrathecal humoral immune responses against measles, rubella, and vari-cella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus-specific IgG1 in varicellazoster virus meningoencephalitis comprised both allotypes. This implies thatG1m1 B cells are selected to the central nervous system of multiple sclerosispatients regardless of specificity and suggests that an antigen-independentmechanism could drive the intrathecal humoral immune response.
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