Abstract
In this thesis we have explored the possibility that mutations occurring at DNA-level might coincide and even be the cause of particular gene fusions at the RNA-level, and have created methods of analysis, integrating both DNA and RNA sequencing data. The software presented, with the working name BUMPKIN-fm, has been run with multiple datasets, and several candidates for further research have been identified. Among these, the fusion STAT3:ETV4 in a prostate cancer patient who also had a mutation within 30 base pairs of the gene breakpoint, stands out in particular, being a known driver event in the development and progression of cancer.