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dc.contributor.authorNordheim, Eirik Berg
dc.date.accessioned2018-08-17T22:01:41Z
dc.date.available2018-08-17T22:01:41Z
dc.date.issued2018
dc.identifier.citationNordheim, Eirik Berg. Integrative analysis of DNA and RNA sequencing data from cancer. Master thesis, University of Oslo, 2018
dc.identifier.urihttp://hdl.handle.net/10852/63165
dc.description.abstractIn this thesis we have explored the possibility that mutations occurring at DNA-level might coincide and even be the cause of particular gene fusions at the RNA-level, and have created methods of analysis, integrating both DNA and RNA sequencing data. The software presented, with the working name BUMPKIN-fm, has been run with multiple datasets, and several candidates for further research have been identified. Among these, the fusion STAT3:ETV4 in a prostate cancer patient who also had a mutation within 30 base pairs of the gene breakpoint, stands out in particular, being a known driver event in the development and progression of cancer.eng
dc.language.isoeng
dc.subjectsomatic mutations
dc.subjectpython
dc.subjectmutations
dc.subjectBUMPKIN
dc.subjectRNA
dc.subjectsoftware
dc.subjectDNA
dc.subjectfusions
dc.subjectbioinformatics
dc.subjectcancer
dc.subjectfusion transcripts
dc.titleIntegrative analysis of DNA and RNA sequencing data from cancereng
dc.typeMaster thesis
dc.date.updated2018-08-17T22:01:41Z
dc.creator.authorNordheim, Eirik Berg
dc.identifier.urnURN:NBN:no-65623
dc.type.documentMasteroppgave
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/63165/11/thesis_final.pdf


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