dc.date.accessioned | 2018-08-06T12:32:57Z | |
dc.date.available | 2018-08-06T12:32:57Z | |
dc.date.created | 2018-03-15T09:51:49Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Prandina, Anthony Herfindal, Lars Radix, S Rongved, Pål Doskeland, Stein Ove Le Borgne, Marc Perret, F . Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of enzyme inhibition and medicinal chemistry (Print). 2018, 33(1), 370-375 | |
dc.identifier.uri | http://hdl.handle.net/10852/62710 | |
dc.description.abstract | Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. Its water solubility has led to the development of new formulations using diverse amphiphilic a-cyclodextrins (CDs). With the per-[6-desoxy-6-(3-perfluorohexylpropanethio)-2,3-di-O-methyl]-a-CD, we succeeded to get iodinin-loaded nanoformulations with good parameters such as a size of 97.9 nm, 62% encapsulation efficiency and efficient control release. The study presents an interesting alternative to optimizing the water solubility of iodinin by chemical modifications of iodinin. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Prandina, Anthony | |
dc.creator.author | Herfindal, Lars | |
dc.creator.author | Radix, S | |
dc.creator.author | Rongved, Pål | |
dc.creator.author | Doskeland, Stein Ove | |
dc.creator.author | Le Borgne, Marc | |
dc.creator.author | Perret, F | |
cristin.unitcode | 185,15,0,0 | |
cristin.unitname | Det matematisk-naturvitenskapelige fakultet | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1572982 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of enzyme inhibition and medicinal chemistry (Print)&rft.volume=33&rft.spage=370&rft.date=2018 | |
dc.identifier.jtitle | Journal of enzyme inhibition and medicinal chemistry (Print) | |
dc.identifier.volume | 33 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 370 | |
dc.identifier.endpage | 375 | |
dc.identifier.doi | http://dx.doi.org/10.1080/14756366.2017.1421638 | |
dc.identifier.urn | URN:NBN:no-65281 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1475-6366 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/62710/1/Enhancement-of-iodinin-solubility.pdf | |
dc.type.version | PublishedVersion | |