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Endothelial IL-33 expression is augmented by adenoviral activation of the DNA damage machinery

Stav-Noraas, Tor Espen; Edelmann, Reidunn Jetne; La Cour Poulsen, Lars; Sundnes, Olav; Phung, Danh; Kuchler, Axel Matthias; Müller, Fredrik; Kamen, Amine A.; Haraldsen, Guttorm; Kaarbø, Mari; Hol, Johanna
Journal article; AcceptedVersion; Peer reviewed
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63884_2_merged_1486390325.pdf (530.1Kb)
Year
2017
Permanent link
http://urn.nb.no/URN:NBN:no-64565

CRIStin
1503484

Is part of
Stav-Noraas, Tor Espen (2018) Interleukin-33 and Notch signaling in antiviral defense and inflammation. Doctoral thesis.
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  • Institutt for klinisk medisin [5640]
  • CRIStin høstingsarkiv [16004]
Original version
Journal of Immunology. 2017, 198 (8), 3318-3325, DOI: http://dx.doi.org/10.4049/jimmunol.1600054
Abstract
IL-33, required for viral clearance by cytotoxic T cells, is generally expressed in vascular endothelial cells in healthy human tissues. We discovered that endothelial IL-33 expression was stimulated as a response to adenoviral transduction. This response was dependent on MRE11, a sensor of DNA damage that can also be activated by adenoviral DNA, and on IRF1, a transcriptional regulator of cellular responses to viral invasion and DNA damage. Accordingly, we observed that endothelial cells responded to adenoviral DNA by phosphorylation of ATM and CHK2 and that depletion or inhibition of MRE11, but not depletion of ATM, abrogated IL-33 stimulation. In conclusion, we show that adenoviral transduction stimulates IL-33 expression in endothelial cells in a manner that is dependent on the DNA-binding protein MRE11 and the antiviral factor IRF1 but not on downstream DNA damage response signaling.

This research has been published in the Journal of Immunology. © 2017 American Association of Immunologists
 
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