Membrane dynamics in cancer cells
Appears in the following Collection
AbstractIn this study we have focused on the role of lipids in intracellular transport, and how trafficking as well as the cell lipidome are regulated in response to various treatments. First, we have elucidated some of the changes that occur in cellular lipid composition during cell crowding in culture, and have suggested a potential link between these changes and the effects on intracellular transport of Shiga toxin. Next, two glucose analogues, 2- deoxy-D-glucose and fluorodeoxyglucose, have been investigated for their potential effects on cellular lipids and intracellular trafficking. We have revealed new effects of these drugs on glycosphingolipid metabolism, as well as on intracellular transport of Shiga toxin. Importantly, our data suggest that these drugs might have novel potential applications both in research and in the clinic.
List of papers
|I. Kavaliauskiene S, Nymark C-M, Bergan J, Simm R, Sylvänne T, Simolin H, Ekroos K, Skotland T, Sandvig K. Cell density-induced changes in lipid composition and intracellular trafficking. Cell. Mol. Life Sci. 2013; 71:1097- 1116. The paper is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1007/s00018-013-1441-y|
|II. Kavaliauskiene S, Skotland T, Sylvänne T, Simolin H, Klokk TI, Torgersen ML, Lingelem AB, Simm R, Ekroos K, Sandvig K. Novel actions of 2-deoxy-Dglucose: protection against Shiga toxins and changes in cellular lipids. Biochem. J. 2015; 470:23-37. The paper is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1042/BJ20141562|
|III. Kavaliauskiene S, Torgersen ML, Klokk TI, Lintonen T, Simolin H, Ekroos K, Skotland T, Sandvig K. Cellular effects of fluorodeoxyglucose: Global changes in the lipidome and alteration in intracellular transport. Under revision. To be published. The paper is not available in DUO awaiting publishing.|