Browsing Institutt for biovitenskap by Title

Now showing items 1-20 of 1074

  • 1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding 
    Hatlem, Daniel; Heggelund, Julie Elisabeth; Burschowsky, Daniel; Krengel, Ute; Kristiansen, Per Eugen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    The major virulence factor of enterotoxigenic Escherichia coli is the heat-labile enterotoxin (LT), an AB5 toxin closely related to the cholera toxin. LT consists of six subunits, the catalytically active A-subunit and ...
  • 454 Pyrosequencing to Describe Microbial Eukaryotic Community Composition, Diversity and Relative Abundance: A Test for Marine Haptophytes 
    Egge, Elianne Sirnæs; Bittner, Lucie; Andersen, Tom; Audic, Stéphane; de Vargas, Colomban; Edvardsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Next generation sequencing of ribosomal DNA is increasingly used to assess the diversity and structure of microbial communities. Here we test the ability of 454 pyrosequencing to detect the number of species present, and ...
  • 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication 
    Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard; Manaf, Adeel; Zhang, Beibei; Vågbø, Cathrine Broberg; Kusnierczyk, Anna; Gilljam, Karin Margaretha; Løvkvam-Køster, Caroline; Otterlei, Marit; Dahl, John Arne; Enserink, Jorrit; Klungland, Arne; Robertson, Adam Brian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ...
  • A Bayesian Binomial Regression Model with Latent Gaussian Processes for Modelling DNA Methylation 
    Hubin, Aliaksandr; Storvik, Geir Olve; Grini, Paul Eivind; Butenko, Melinka Alonso (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Epigenetic observations are represented by the total number of reads from a given pool of cells and the number of methylated reads, making it reasonable to model this data by a binomial distribution. There are numerous ...
  • A classification framework for Bacillus anthracis defined by global genomic structure 
    Bruce, Spencer A; Schiraldi, Nicholas J; Kamath, Pauline L.; Easterday, William Ryan; Turner, Wendy C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Bacillus anthracis , the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study, whole‐genome sequence analysis of over 350 B. anthracis ...
  • “A cleaner break”: Genetic divergence between geographic groups and sympatric phenotypes revealed in ballan wrasse (Labrus bergylta) 
    Seljestad, Gaute; Sanchez, Maria Quintela; Faust, Ellika; Halvorsen, Kim Aleksander Tallaksen; Besnier, Francois; Jansson, Eeva; Dahle, Geir; Knutsen, Halvor; André, Carl; Folkvord, Arild; Glover, Kevin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Capture and long-distance translocation of cleaner fish to control lice infestations on marine salmonid farms has the potential to influence wild populations via overexploitation in source regions, and introgression in ...
  • A computational model for gonadotropin releasing cells in the teleost fish medaka 
    Halnes, Geir; Tennøe, Simen; Haug, Trude; Einevoll, Gaute; Weltzien, Finn-Arne; Hodne, Kjetil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Pituitary endocrine cells fire action potentials (APs) to regulate their cytosolic Ca2+ concentration and hormone secretion rate. Depending on animal species, cell type, and biological conditions, pituitary APs are generated ...
  • A de novo transcriptome assembly for the bath sponge Spongia officinalis, adjusting for microsymbionts 
    Manousaki, Tereza; Koutsouveli, Vasiliki; Lagnel, Jacques; Kollias, Spyridon; Tsigenopoulos, Costas S; Arvanitidis, Christos; Magoulas, Antonios; Dounas, Costas; Dailianis, Thanos (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objectives We report a transcriptome acquisition for the bath sponge Spongia officinalis, a non-model marine organism that hosts rich symbiotic microbial communities. To this end, a pipeline was developed to efficiently ...
  • A genome-skimmed phylogeny of a widespread bryozoan family, Adeonidae 
    Orr, Russell J S; Haugen, Marianne N; Berning, Björn; Bock, Philip; Cumming, Robyn L; Florence, Wayne K; Hirose, Masato; Di Martino, Emanuela; Ramsfjell, Mali H; Sannum, Maja M; Smith, Abigail M; Vieira, Leandro M; Waeschenbach, Andrea; Liow, Lee Hsiang (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Understanding the phylogenetic relationships among species is one of the main goals of systematic biology. Simultaneously, credible phylogenetic hypotheses are often the first requirement for ...
  • A genome-wide linkage map for the house sparrow (Passer domesticus) provides insights into the evolutionary history of the avian genome 
    Hagen, Ingerid Julie; Lien, Sigbjørn; Billing, Anna Maria; Elgvin, Tore Oldeide; Trier, Cassandra Nicole; Niskanen, Alina K.; Tarka, Maja; Slate, Jon; Sætre, Glenn-Peter; Jensen, Henrik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The house sparrow is an important model species for studying physiological, ecological and evolutionary processes in wild populations. Here, we present a medium density, genome wide linkage map for house sparrow (Passer ...
  • A high-quality assembly of the nine-spined stickleback (Pungitius pungitius) genome 
    Varadharajan, Srinidhi; Rastas, Pasi; Löytynoja, Ari; Matschiner, Michael; Calboli, Federico C. F.; Guo, Baocheng; Nederbragt, Alexander Johan; Jakobsen, Kjetill Sigurd; Merilä, Juha (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The Gasterosteidae fish family hosts several species that are important models for eco-evolutionary, genetic and genomic research. In particular, a wealth of genetic and genomic data has been generated for the three-spined ...
  • A New Look at the Functional Organization of the Golgi Ribbon 
    Saraste, Jaakko; Prydz, Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    A characteristic feature of vertebrate cells is a Golgi ribbon consisting of multiple cisternal stacks connected into a single-copy organelle next to the centrosome. Despite numerous studies, the mechanisms that link the ...
  • A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes. 
    Lode, Heidrun Elisabeth; Gjølberg, TT; Foss, Stian; Sivertsen, Magne S.; Brustugun, Jørgen; Andersson, Yvonne; Jørstad, Øystein Kalsnes; Moe, Morten Carstens; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Intravitreal injections of antibody-based biologics targeting vascular endothelial growth factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment associated with prevalent retinal ...
  • A novel ultra high-throughput 16S rRNA gene amplicon sequencing library preparation method for the Illumina HiSeq platform 
    de Muinck, Eric J; Trosvik, Pål; Gilfillan, Gregor D; Hov, Johannes R; Sundaram, Arvind Y M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background Advances in sequencing technologies and bioinformatics have made the analysis of microbial communities almost routine. Nonetheless, the need remains to improve on the techniques used for gathering ...
  • A Research-Inspired Biochemistry Laboratory Module - Combining Expression, Purification, Crystallization, Structure-Solving, and Characterization of a Flavodoxin-like Protein 
    Hammerstad, Marta; Kjendseth, Åsmund Røhr; Hersleth, Hans-Petter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Many laboratory courses consist of short and seemingly unconnected individual laboratory exercises. To increase the course consistency, relevance, and student engagement, we have developed a research‐inspired and project‐based ...
  • A single ectomycorrhizal plant root system includes a diverse and spatially structured fungal community 
    Thoen, Ella; Aas, Anders Bjørnsgard; Vik, Unni; Brysting, Anne Krag; Skrede, Inger; Carlsen, Tor; Kauserud, Håvard (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Although only a relatively small proportion of plant species form ectomycorrhizae with fungi, it is crucial for growth and survival for a number of widespread woody plant species. Few studies have attempted to investigate ...
  • A single pulse of diffuse contaminants alters the size distribution of natural phytoplankton communities 
    Baho, Didier Ludovic; Pomati, Francesco; Leu, Eva; Hessen, Dag Olav; Moe, S. Jannicke; Norberg, Jon; Nizzetto, Luca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The presence of a multitude of bioactive organic pollutants collectively classified as pharmaceuticals and personal care products (PPCPs) in freshwaters is of concern, considering that ecological assessments of their ...
  • A single vibrionales 16S rRNA oligotype dominates the intestinal microbiome in two geographically separated Atlantic cod populations 
    Riiser, Even Sannes; Haverkamp, Thomas Hendricus Augustus; Borgan, Ørnulf; Jakobsen, Kjetill Sigurd; Jentoft, Sissel; Star, Bastiaan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Atlantic cod (Gadus morhua) provides an interesting species for the study of host-microbe interactions because it lacks the MHC II complex that is involved in the presentation of extracellular pathogens. Nonetheless, little ...
  • A stainless-steel mortar, pestle and sleeve design for the efficient fragmentation of ancient bone 
    Gondek, Agata Teresa; Boessenkool, Sanne; Star, Bastiaan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Different types of milling equipment – such as oscillating ball mills, freezer mills, mortar and pestle – can be used to fragment ancient bone prior to DNA extraction. However, each of these tools is associated with practical ...
  • A survey of protein interaction data and multigenic inherited disorders 
    Mora, Antonio; Michalickova, Katerina; Donaldson, Ian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Background Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein ...