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Transport of nanoparticles across the endothelial cell layer 
Skotland, Tore; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion, 2021)
Studies of how intravenously injected nanoparticles (NPs) enter tumours and are taken up by tumour cells have been discussed for more than three decades. Despite this, we still have much to learn about interactions between ...
A risk assessment of the effects of mercury on Baltic Sea, Greater North Sea and North Atlantic wildlife, fish and bivalves 
Dietz, Rune; Fort, Jérôme; Sonne, Christian; Albert, Céline; Bustnes, Jan Ove; Christensen, Thomas Kjær; Ciesielski, Tomasz Maciej; Danielsen, Jóhannis; Dastnai, Sam; Eens, Marcel; Erikstad, Kjell E; Galatius, Anders; Garbus, Svend-Erik; Gilg, Oliver; Hanssen, Sveinn Are; Helander, Björn; Helberg, Morten; Jaspers, Veerle; Jenssen, Bjørn Munro; Jónsson, Jón Einar; Kauhala, Kaarina; Kolbeinsson, Yann; Kyhn, Line A.; Labansen, Aili Lage; Larsen, Martin M.; Lindstrøm, Ulf; Reiertsen, Tone Kristin; Rigét, Frank F.; Roos, Anna; Strand, Jakob; Strøm, Hallvard; Søndergaard, Jens; Sun, Jiachen; Teilmann, Jonas; Therkildsen, Ole Roland; Thórarinsson, Thorkell Lindberg; Tjørnløv, Rune Skjold; Wilson, Simon; Eulaers, Igor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
A wide range of species, including marine mammals, seabirds, birds of prey, fish and bivalves, were investigated for potential population health risks resulting from contemporary (post 2000) mercury (Hg) exposure, using ...
Depletion of coastal predatory fish sub-stocks coincided with the largest sea urchin grazing event observed in the NE Atlantic 
Norderhaug, Kjell Magnus; Nedreaas, Kjell Harald; Huserbråten, Mats; Moland, Even (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract In this contribution, we propose fishery driven predator release as the cause for the largest grazing event ever observed in the NE Atlantic. Based on the evolving appreciation of limits to population connectivity, ...
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour 
Rey, Sonia; Jin, Xingkun; Damsgård, Børge; Bégout, Marie-Laure; Mackenzie, Simon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Consistent individual differences in behaviour, known as animal personalities, have been demonstrated within and across species. In fish, studies applying an animal personality approach have been ...
Fungal sporocarps house diverse and host-specific communities of fungicolous fungi 
Maurice, Sundy Ursula Mary Jane; Arnault, Gontran; Nordén, Jenni; Botnen, Synnøve Smebye; Miettinen, Otto; Kauserud, Håvard (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
porocarps (fruit bodies) are the sexual reproductive stage in the life cycle of many fungi. They are highly nutritious and consequently vulnerable to grazing by birds and small mammals, and invertebrates, and can be infected ...
Characterization of transcription factor networks upon FOXA1 overexpression in prostate cancer 
Abdelhalim, Mohamed Ibrahim Mohamed (Master thesis / Masteroppgave, 2020)
Understanding the role of RNA binding protein QKI in the regulation of H2A.Z variants in breast cancer Restricted Access
Jinnurine, Tasmia (Master thesis / Masteroppgave, 2020)
Breast cancer is the most predominant form of cancer in females worldwide. High throughput gene expression analysis has led to classification of breast cancer into distinct molecular subtypes (Parker et al., 2009; Perou ...
NucBreak: location of structural errors in a genome assembly by using paired-end Illumina reads 
Khelik, Ksenia; Sandve, Geir K; Nederbragt, Alexander J; Rognes, Torbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Advances in whole genome sequencing strategies have provided the opportunity for genomic and comparative genomic analysis of a vast variety of organisms. The analysis results are highly dependent on the quality ...
Novel mechanisms of DNA damage and replication stress signaling: Functional roles of the WDR82/PNUTS-PP1 phosphatase complex 
Sandquist, Lise Ellefsen (Doctoral thesis / Doktoravhandling, 2020)
DNA damaging agents, such as ionizing radiation and many chemotherapeutic drugs, are used in cancer treatment to kill cancer cells. However, networks of signaling cascades induced by DNA damage counteract this by leading ...
Evolvability and Robustness A Paradox in Evolutionary Theory 
Syrowatka, Christine (Doctoral thesis / Doktoravhandling, 2020)
Research in evolutionary biology is driven by curiosity about the evolution of complex organisms. Their origin and maintenance depend on two conflicting properties ‐ evolvability and robustness. Evolvability is the ability ...
Biodiversity in the dark: root-associated fungi in the Arctic 
Botnen, Synnøve Smebye (Doctoral thesis / Doktoravhandling, 2020)
In her PhD thesis, Synnøve Smebye Botnen investigated the diversity and community ecology of Arctic fungi, from beforehand a poorly studied group of organisms. Climate change will have major impacts on Arctic ecosystems ...
Targeting cancer cells through inhibition of cell cycle checkpoint kinases 
Hauge, Sissel (Doctoral thesis / Doktoravhandling, 2020)
Targeting the DNA damage response to selectively kill cancer cells is a topic of great interest in the field of cancer research. Inhibitors of the cell cycle checkpoint kinases WEE1, CHK1 and ATR have been developed, and ...
Crop Pollination in Small-Scale Agriculture in Tanzania: Household Dependence, Awareness and Conservation 
Sawe, Thomas; Nielsen, Anders; Eldegard, Katrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Global economic value of agriculture production resulting from animal pollination services has been estimated to be $235–$577 billion. This estimate is based on quantification of crops that are available at the global ...
Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model 
Skuland, Tonje; Låg, Marit; Gutleb, Arno C; Brinchmann, Bendik C; Serchi, Tommaso; Øvrevik, Johan; Holme, Jørn A; Refsnes, Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Silica nanoparticles (SiNPs) are among the most widely manufactured and used nanoparticles. Concerns about potential health effects of SiNPs have therefore risen. Using a 3D tri-culture model ...
Colorectal Cancer and the Goblets of Mucins: Effects of Hypersecreting Goblet Cells and Mucus Accumulation in disease Restricted Access
Simensen, Julia Elisabeth (Master thesis / Masteroppgave, 2020)
Sea ice, temperature, and prey effects on annual variations in mean lengths of a key Arctic fish, Boreogadus saida, in the Barents Sea 
Dupont, Nicolas; Durant, Joel Marcel; Langangen, Øystein; Gjøsæter, Harald; Stige, Leif Christian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Oceanographic conditions in the Arctic are changing, with sea ice cover decreasing and sea temperatures increasing. Our understanding of the effects on marine populations in the area is, however, limited. ...
Water browning controls adaptation and associated trade-offs in phytoplankton stressed by chemical pollution 
Rizzuto, Simone; Thrane, Jan-Erik; Baho, Didier Ludovic; Jones, Kevin C.; Zhang, Hao; Hessen, Dag Olav; Nizzetto, Luca; Leu, Eva Susanne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The acquisition of tolerance to an environmental stressor can result in organisms displaying slower growth after stress release. While well-grounded in the theory, empirical evidence of the trade-off between stress tolerance ...
The inverse autotransporters of Yersinia ruckeri, YrInv and YrIlm, contribute to biofilm formation and virulence 
Wróbel, Agnieszka Ewelina; Saragliadis, Athanasios; Perez-Ortega, J; Sittman, C; Gottig, Stephan; Liskiewicz, Krystyna Anna; Spence, Maria Helle; Schneider, Kenneth; Leo, Jack Christopher; Arenas, J; Linke, Dirk (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Yersinia ruckeri causes enteric redmouth disease (ERM) that mainly affects salmonid fishes and leads to significant economic losses in the aquaculture industry. An increasing number of outbreaks and the lack of effective ...
Genetic variation and temperature affects hybrid barriers during interspecific hybridization 
Bjerkan, Katrine; Hornslien, Karina Stensland; Johannessen, Ida Marie; Krabberød, Anders Kristian; van Ekelenburg, Yuri Stephan; Kalantarian, Maryam; Shirzadi, Reza; Comai, Luca; Brysting, Anne Krag; Bramsiepe, Jonathan; Grini, Paul Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Genomic imprinting regulates parent‐specific transcript dosage during seed development and is mainly confined to the endosperm. Elucidation of the function of many imprinted genes has been hampered by the lack of corresponding ...
Circular food: crops from digested waste in a controlled environment 
Stoknes, Ketil (Doctoral thesis / Doktoravhandling, 2020)
The food we eat can have a huge environmental impact. Steaks, tomatoes and bread are typically farmed and transported using fossil resources, while nutrients are lost and much of the product is wasted on its way to our ...
Exposure to workplace bullying, microRNAs and pain. Evidence of a moderating effect of miR-30c rs928508 and miR-223 rs3848900 
Jacobsen, Daniel Pitz; Eriksen, Mina Baarnes; Rajalingam, Dhaksshaginy; Nymoen, Ingeborg; Nielsen, Morten Birkeland; Einarsen, Ståle; Gjerstad, Johannes (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Prolonged exposure to bullying behaviors may give rise to symptoms such as anxiety, depression and chronic pain. Earlier data suggest that these symptoms often are associated with stress-induced low-grade systemic inflammation. ...
Testing eco‐evolutionary predictions using fossil data: Phyletic evolution following ecological opportunity. 
Voje, Kjetil L. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Fossil sequences provide observations of phenotypes within a lineage over time and represent essential data for increasing our understanding of phyletic evolution beyond microevolutionary timescales. I investigate if fossil ...
Characterization and pro‐inflammatory potential of indoor mold particles 
Holme, Jørn Andreas; Øya, Elisabeth Tveiten; Afanou, Komlavi Anani; Øvrevik, Johan; Wijnand, Eduard (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
A number of epidemiological studies find an association between indoor air dampness and respiratory health effects. This is often suggested to be linked to enhanced mold growth. However, the role of mold are obviously ...
Evolutionary selection of biofilm-mediated extended phenotypes in Yersinia pestis in response to a fluctuating environment 
Cui, Yujun; Schmid, Boris Valentijn; Cao, Hanli; Dai, Xiang; Du, Zhongmin; Easterday, William Ryan; Fang, Haihong; Guo, Chenying; Huang, Shanqian; Liu, Wanbing; Qi, Zhizhen; Song, Yajun; Tian, Huaiyu; Wang, Min; Wu, Yarong; Xu, Bing; Yang, Chao; Yang, Jing; Yang, Xianwei; Zhang, Qingwen; Jakobsen, Kjetill Sigurd; Zhang, Yujiang; Stenseth, Nils Christian; Yang, Ruifu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Yersinia pestis is transmitted from fleas to rodents when the bacterium develops an extensive biofilm in the foregut of a flea, starving it into a feeding frenzy, or, alternatively, during a brief period directly after ...
Catching a SPY: Using the SpyCatcher-SpyTag and Related Systems for Labeling and Localizing Bacterial Proteins 
Hatlem, Daniel; Trunk, Thomas; Linke, Dirk; Leo, Jack Christopher (Chapter / Bokkapittel / PublishedVersion; Peer reviewed, 2020)
The SpyCatcher-SpyTag system was developed seven years ago as a method for protein ligation. It is based on a modified domain from a Streptococcus pyogenes surface protein (SpyCatcher), which recognizes a cognate 13-amino-acid ...
Protease activated receptors (PAR)‐1 and ‐2 mediate cellular effects of factor VII activating protease (FSAP). 
Byskov, Kristina; M. le Gall, Sylvain; Thiede, Bernd; Camerer, Eric; Kanse, Sandip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Factor VII activating protease (FSAP) is a circulating serine protease implicated in thrombosis, atherosclerosis, stroke, and cancer. Using an overexpression strategy, we have systematically investigated the role of protease ...
Demographic history has shaped the strongly differentiated corkwing wrasse populations in Northern Europe. 
Mattingsdal, Morten; Jorde, Per Erik; Knutsen, Halvor; Jentoft, Sissel; Stenseth, Nils Christian; Sodeland, Marte; Robalo, Joana I.; Hansen, Michael M.; André, Carl; Gonzalez, Enrique Blanco (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Understanding the biological processes involved in genetic differentiation and divergence between populations within species is a pivotal aim in evolutionary biology. One particular phenomenon that requires clarification ...
Ecosystem consequences of multi-trait response to environmental changes in Japanese medaka, Oryzias latipes 
Diaz Pauli, Beatriz; Edeline, Eric; Evangelista, Charlotte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Intraspecific trait variation has large effects on the ecosystem and is greatly affected by human activities. To date, most studies focused on single-trait analyses, while considering multiple traits is expected to better ...
Novel cancer-related roles of GCN2 
Sharma Humagain, Prabin (Master thesis / Masteroppgave, 2020)
GCN2, an amino-acid deprivation sensor is one of the kinases activated during the integrated stress response. Its role in normal as well as in cancer cells during stress induced by starvation has garnered a lot of attention. ...
Screening, characterization and co-crystallization of inhibitors for human BCAT2 Restricted Access
Englund, Andrea Nikoline (Master thesis / Masteroppgave, 2020)
The Genome of the Great Gerbil Reveals Species-Specific Duplication of an MHCII Gene 
Nilsson, Pernille; Solbakken, Monica Hongrø; Schmid, Boris Valentijn; Orr, Russell; Lv, Ruichen; Cui, Yujun; Song, Yajun; Zhang, Yujiang; Baalsrud, Helle Tessand; Tørresen, Ole K.; Stenseth, Nils Christian; Yang, Ruifu; Jakobsen, Kjetill Sigurd; Easterday, William Ryan; Jentoft, Sissel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract The great gerbil (Rhombomys opimus) is a social rodent living in permanent, complex burrow systems distributed throughout Central Asia, where it serves as the main host of several important vector-borne ...
Ancient DNA of Tuna bones from the Alveberget excavation in Arendal, Norway 
Ferrari, Giada; Martinez Garcia, Lourdes; Berg-Hansen, Inger Marie; Mansrud, Anja; Star, Bastiaan (Research report / Forskningsrapport, 2020)
Characterization of NK cell-derived exosomes, and their tumor-targeting ability Restricted Access
Larsen, Miriam Aarsund (Master thesis / Masteroppgave, 2020)
The last moves: The effect of hunting and culling on the risk of disease spread from a population of reindeer 
Mysterud, Atle; Rauset, Geir Rune; Van Moorter, Bram; Andersen, Roy; Strand, Olav; Rivrud, Inger Maren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
1. Hunting and culling are frequently used to combat infectious wildlife diseases. The aim is to markedly lower population density in order to limit disease transmission or to eradicate the host. Massive host culling can ...
Carbon export is facilitated by sea urchins transforming kelp detritus 
Filbee-Dexter, Karen; Pedersen, Morten Foldager; Fredriksen, Stein; Norderhaug, Kjell Magnus; Rinde, Eli; Kristiansen, Trond; Albretsen, Jon; Wernberg, Thomas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
With the increasing imperative for societies to act to curb climate change by increasing carbon stores and sinks, it has become critical to understand how organic carbon is produced, released, transformed, transported, and ...
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies. 
Lau, Corinna; McAdam, MB; Bergseth, G; Grevys, Algirdas; Bruun, JA; Ludviksen, Judith K; Fure, Hilde; Espevik, Terje; Moen, A; Andersen, Jan Terje; Mollnes, Tom Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The mechanism of action of recombinant IgG2/4 antibodies involves blocking of their target without the induction of effector functions. Examples are eculizumab (Soliris®), which is used clinically to block complement factor ...
Role of endoplasmic reticulum Ca2+ depletion, the unfolded protein response, and autophagy in thapsigargin-induced cell death 
Lindner, Paula (Doctoral thesis / Doktoravhandling, 2020)
Thapsigargin (Tg) is a naturally occurring plant compound that potently blocks the endoplasmic reticulum (ER) Ca2+ pump SERCA (sarco/endoplasmic reticulum Ca2+ ATPase). This leads to ER Ca2+ depletion, unresolved ER stress, ...
Implications of Allee effects for fisheries management in a changing climate: evidence from Atlantic cod 
Winter, Anna-Marie; Richter, Andries Peter; Eikeset, Anne Maria (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
There are concerns that increasing anthropogenic stressors can cause catastrophic transitions in ecosystems. Such shifts have large social, economic, and ecological consequences and therefore have important management ...
Diel vertical migration and individual behavior of nekton beyond the ocean's twilight zone 
Kaartvedt, Stein; Røstad, Anders; Christiansen, Svenja; Klevjer, Thor Aleksander (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Diel vertical migration (DVM) is normally limited to the upper 1000 m. However, the use of ship-borne and stationary submerged echosounders in the Red Sea unveiled consistent formation of daytime patches extending to ...
Population variability under stressors is dependent on body mass growth and asymptotic body size 
Leonie, Färber; Rob, van Gemert; Langangen, Øystein; Durant, Joel Marcel; Ken Hasle, Andersen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The recruitment and biomass of a fish stock are influenced by their environmental conditions and anthropogenic pressures such as fishing. The variability in the environment often translates into fluctuations in recruitment, ...
The Fusarium mycotoxin, 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) induces vacuolization in HepG2 cells 
Solhaug, Anita; Torgersen, Maria Lyngaas; Holme, Jørn Andreas; Wiik-Nilsen, Jannicke; Thiede, Bernd; Eriksen, Gunnar Sundstøl (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The mycotoxin 2-Amino-14,16-dimethyloctadecan-3-ol (AOD) has been isolated from cultures of the fungus Fusarium avenaceum, one of the most prevalent Fusarium species. AOD is an analogue of sphinganine and 1-deoxysphinganine, ...
Characterization and comparative analyses of type Vd-secreted phospholipases expressed in pathogenic bacteria 
Trunk, Thomas (Doctoral thesis / Doktoravhandling, 2020)
Autotransporters, or type 5 secretion systems (T5SS), are widespread surface proteins of Gram-negative bacteria often associated with virulence. Three novel T5dSSs expressed in the fish pathogen Aeromonas hydrophila, the ...
Age of European silver eels during a period of declining abundance in Norway 
Durif, Caroline; Diserud, Ola Håvard; Sandlund, Odd Terje; Thorstad, Eva Bonsak; Poole, Russell; Bergesen, Knut; Bergesen, Knut Aanestad; Escobar-Lux, Rosa H; Shema, Steven; Vøllestad, Leif Asbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The European eel (Anguilla anguilla) is critically endangered throughout its range. Knowledge about age distribution of future spawners (silver eels) is essential to monitor the status and contribute to the recovery of ...
Microcystins in European Noble Crayfish Astacus astacus in Lake Steinsfjorden, a Planktothrix-Dominated Lake 
Samdal, Ingunn Anita; Strand, David; Ballot, Andreas; Rusch, Johannes; Haande, Sigrid; Løvberg, Kjersti Eriksen; Miles, Christopher Owen; Vrålstad, Trude (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Lake Steinsfjorden, an important Norwegian location for noble crayfish (Astacus astacus), is often affected by cyanobacterial blooms caused by microcystin (MC)-producing Planktothrix spp. The impact of MCs on noble crayfish ...
Effects of climate and spawning stock structure on the spatial distribution of Northeast Arctic cod larvae 
Endo, Clarissa; Vikebø, Frode Bendiksen; Yaragina, Natalia A.; Hjøllo, Solfrid Sætre; Stige, Leif Christian (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Abstract The spatial distribution of fish early life stages can impact recruitment at later stages and affect population size and resilience. Northeast Arctic (NEA) cod spawning occurs along the Norwegian coast. ...
Biological response and cytotoxicity induced by lipid nanocapsules 
Szwed, Marzena; Torgersen, Maria L; Kumari, Remya V; Yadava, Sunil K; Pust, Sascha; Iversen, Tore G; Skotland, Tore; Giri, Jyotsnendu; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Lipid nanocapsules (LNCs) are promising vehicles for drug delivery. However, since not much was known about cellular toxicity of these nanoparticles in themselves, we have here investigated the ...
Livestock owners’ worry and fear of tick-borne diseases 
Johansson, Maria; Mysterud, Atle; Flykt, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Recent global changes have led to an increase in distribution of ticks towards higher elevation and latitude in Europe and livestock are at increasing risk of contracting tick-borne diseases, but psychological ...
Estimating uncertainty in divergence times among three-spined stickleback clades using the multispecies coalescent 
Fang, Bohao; Merilä, Juha; Matschiner, Michael; Momigliano, Paolo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Incomplete lineage sorting (ILS) can lead to biased divergence time estimates. To explore if and how ILS has influenced the results of a recent worldwide phylogeny of three-spined sticklebacks (Gasterosteus aculeatus), we ...
Match-mismatch dynamics in the Norwegian-Barents Sea system 
Ferreira, Ana Sofia De Araújo; Stige, Leif Christian; Neuheimer, Anna B.; Bogstad, Bjarte; Yaragina, Natalia A.; Prokopchuk, Irina; Durant, Joel Marcel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
A key process affecting variation in the recruitment of fish into fisheries is the spatio-temporal overlap between prey and predator (match-mismatch hypothesis, MMH). The Northeast Arctic cod Gadus morhua and its dominant ...
A genome-wide linkage map for the house sparrow (Passer domesticus) provides insights into the evolutionary history of the avian genome 
Hagen, Ingerid Julie; Lien, Sigbjørn; Billing, Anna Maria; Elgvin, Tore Oldeide; Trier, Cassandra Nicole; Niskanen, Alina K.; Tarka, Maja; Slate, Jon; Sætre, Glenn-Peter; Jensen, Henrik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The house sparrow is an important model species for studying physiological, ecological and evolutionary processes in wild populations. Here, we present a medium density, genome wide linkage map for house sparrow (Passer ...
The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection 
Dobrovolska, Olena; Brilkov, Maxim; Madeleine, Noëlly; Ødegaard-Fougner, Øyvind; Strømland, Øyvind; Martin, Stephen R.; De Marco, Valeria; Christodoulou, Evangelos; Teigen, Knut; Isaksson, Johan; Underhaug, Jarl; Reuter, Nathalie; Aalen, Reidunn B.; Aasland, Rein; Halskau, Øyvind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Chromatin post‐translational modifications are thought to be important for epigenetic effects on gene expression. Methylation of histone N‐terminal tail lysine residues constitutes one of many such modifications, executed ...
Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua) 
Dale, Karina; Yadetie, Fekadu; Müller, Mette Helen Bjørge; Pampanin, Daniela Maria; Gilabert, Alejandra; Zhang, Xiaokang; Tairova, Zhanna; Haarr, Ane; Lille-Langøy, Roger; Lyche, Jan Ludvig; Porte, Cinta; Karlsen, Odd Andre; Goksøyr, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The aim of the present study was to investigate effects of defined mixtures of polycyclic aromatic hydrocarbons (PAHs) and perfluoroalkyl substances (PFASs), at low, environmentally relevant (1× = L), or high (20× = H) ...
Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases 
Låg, Marit; Øvrevik, Johan; Refsnes, Magne; Holme, Jørn A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Epidemiological studies have found strong associations between air pollution and respiratory effects including development and/or exacerbation of asthma and chronic obstructive pulmonary disease (COPD) as well as increased ...
In-depth characterization of Trichoderma reesei cellobiohydrolase TrCel7A produced in Nicotiana benthamiana reveals limitations of cellulase production in plants by host-specific post-translational modifications 
van Eerde, André; Varnai, Aniko; Jameson, John-Kristian; Paruch, Lisa; Moen, Anders; Anonsen, Jan Haug; Chylenski, Piotr; Steen, Hege; Heldal, Inger; Bock, Ralph; Eijsink, Vincent; Clarke, Jihong Liu (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Sustainable production of biofuels from lignocellulose feedstocks depends on cheap enzymes for degradation of such biomass. Plants offer a safe and cost‐effective production platform for biopharmaceuticals, vaccines and ...
Molecular mechanisms involved in the regulation of the gap junction channel protein connexin43 by the E3 ubiquitin ligase ITCH Restricted Access
Bruusgaard, Emilie (Master thesis / Masteroppgave, 2020)
Assessing graph-based read mappers against a baseline approach highlights strengths and weaknesses of current methods 
Grytten, Ivar; Rand, Knut D; Nederbragt, Alexander J; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Graph-based reference genomes have become popular as they allow read mapping and follow-up analyses in settings where the exact haplotypes underlying a high-throughput sequencing experiment are ...
A classification framework for Bacillus anthracis defined by global genomic structure 
Bruce, Spencer A; Schiraldi, Nicholas J; Kamath, Pauline L.; Easterday, William Ryan; Turner, Wendy C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Bacillus anthracis , the causative agent of anthrax, is a considerable global health threat affecting wildlife, livestock, and the general public. In this study, whole‐genome sequence analysis of over 350 B. anthracis ...
Preying on seals pushes killer whales from Norway above pollution effects thresholds 
Andvik, Clare; Jourdain, Eve; Ruus, Anders; Lyche, Jan Ludvig; Karoliussen, Richard; Borgå, Katrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Killer whales (Orcinus orca) are at risk from high levels of biomagnifying pollutants, such as polychlorinated biphenyls (PCBs) and mercury (Hg). Previous toxicological risk assessments for the Norwegian killer whale ...
An imaging-based study of the dynamical behavior of Rab proteins during endosomal maturation Restricted Access
Manovaseegaran, Vinodha (Master thesis / Masteroppgave, 2020)
An interplay between nonsense-mediated decay and DNA damage response pathways Restricted Access
Ghasemi, Fatemeh (Master thesis / Masteroppgave, 2020)
Nonsense-mediated decay (NMD) is an RNA processing pathway that helps maintain the quality of gene expression. It is best known as a surveillance system that detects aberrant mRNA molecules that result from mutations leading ...
Characterizing the role of invariant chain and its interactors in endosomal maturation and trafficking Restricted Access
Sendstad, Ingrid Hegnes (Master thesis / Masteroppgave, 2020)
The endogenous cellular machinery mediates the fine-tuned regulatory mechanisms over the endosomal pathway. The fidelity of the process comes from the means of Rabs, SNAREs, SM-proteins, and tethering complexes, mediating ...
The role of lipid species in membranes and cancer-related changes. 
Skotland, Tore; Kavaliauskiene, Simona; Sandvig, Kirsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Several studies have demonstrated interactions between the two leaflets in membrane bilayers and the importance of specific lipid species for such interaction and membrane function. We here discuss these investigations ...
Landscape genetics of northern crested newt Triturus cristatus populations in a contrasting natural and human-impacted boreal forest 
Haugen, Hanne; Linløkken, Arne; Østbye, Kjartan; Heggenes, Jan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Among vertebrates, amphibians currently have the highest proportion of threatened species worldwide, mainly through loss of habitat, leading to increased population isolation. Smaller amphibian populations may lose more ...
Species delimitation in the Chlorophytum andongense complex Restricted Access
Sævareid, Malin (Master thesis / Masteroppgave, 2020)
Several subgroups in Genus Chlorophytum has been identified by molecular, morphological and chromosome research. One of the subgroups has been referred to as “The paniculate spongy-rooted group”, where the delimitation of ...
Alien species in Norway: results from quantitative ecological impact assessments 
Sandvik, Hanno; Hilmo, Olga; Henriksen, Snorre; Elven, Reidar; Åsen, Per Arvid; Hegre, Hanne; Pedersen, Oddvar; Pedersen, Per Anker; Solstad, Heidi; Vandvik, Vigdis; Westergaard, Kristine Bakke; Ødegaard, Frode; Åström, Sandra Charlotte Helene; Elven, Hallvard; Endrestøl, Anders; Gammelmo, Øivind; Hatteland, Bjørn Arild; Solheim, Halvor; Nordén, Björn; Sundheim, Leif; Talgø, Venche; Falkenhaug, Tone; Gulliksen, Bjørn; Jelmert, Anders; Oug, Eivind; Sundet, Jan Henry; Forsgren, Elisabet; Finstad, Anders Gravbrøt; Hesthagen, Trygve H.; Nedreaas, Kjell Harald; Wienerroither, Rupert; Husa, Vivian; Fredriksen, Stein; Sjøtun, Kjersti; Steen, Henning; Hansen, Haakon; Hamnes, Inger Sofie; Karlsbakk, Egil; Magnusson, Christer; Ytrehus, Bjørnar; Pedersen, Hans Christian; Swenson, Jon; Syvertsen, Per Ole; Stokke, Bård Gunnar; Gjershaug, Jan Ove; Dolmen, Dag; Kjærstad, Gaute; Johnsen, Stein Ivar; Jensen, Thomas Correll; Hassel, Kristian; Gederaas, Lisbeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
1. Due to globalisation, trade and transport, the spread of alien species is increasing dramatically. Some alien species become ecologically harmful by threatening native biota. This can lead to irreversible changes in ...
Consequences of barriers and changing seasonality on population dynamics and harvest of migratory ungulates 
Van Moorter, Bram; Engen, Steinar; Fryxell, John M.; Panzacchi, Manuela; Nilsen, Erlend Birkeland; Mysterud, Atle (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Many animal populations providing ecosystem services, including harvest, live in seasonal environments and migrate between seasonally distinct ranges. Unfortunately, two major sources of human-induced global change threaten ...
Determining Nature Types in Norway (NiN) by soil eDNA metabarcoding Restricted Access
Engelstad, Mari Elisabeth (Master thesis / Masteroppgave, 2020)
The continuing pressure on natural resources and the expansion of urban development necessitates up-to-date knowledge about the distribution and status of different kinds of nature. Land-cover maps are created by mapping ...
Relevansen av kompetansen fra matematikk R2 i beregningsorientert biologi 
Rudberg, Sofie (Master thesis / Masteroppgave, 2020)
Sammendrag Den moderne biologien formes av statistikk og nye metoder for å analysere de store datamengdene fagfeltet består av. Dette gjør at samfunnet trenger biologer med tilstrekkelig eksperimentell og teoretisk bakgrunn ...
Exploring the role of Rab3 in exosome release from prostate cancer cells Restricted Access
Romero, Silvana Angelica Troncoso (Master thesis / Masteroppgave, 2020)
Exosomes are extracellular vesicles (EVs) released by cells upon fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). Various aspects concerning the molecular mechanisms involved in exosome biogenesis and ...
Mapping enzyme activity on tissue by functional mass spectrometry imaging 
Hamilton, Brett R.; Marshall, David L.; Casewell, Nicholas R.; Harrison, Robert A.; Blanksby, Stephen J.; Undheim, Eivind Andreas Baste (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Enzymes are central components of most physiological processes, and are consequently implicated in various pathologies. High‐resolution maps of enzyme activity within tissues therefore represent powerful tools for elucidating ...
Isotopic niche differs between seal and fish-eating killer whales (Orcinus orca) in northern Norway 
Jourdain, Eve; Andvik, Clare Margaret; Karoliussen, Richard; Ruus, Anders; Vongraven, Dag; Borgå, Katrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Ecological diversity has been reported for killer whales (Orcinus orca) throughout the North Atlantic but patterns of prey specialization have remained poorly understood. We quantify interindividual dietary variations in ...
Drug-Loaded Photosensitizer-Chitosan Nanoparticles for Combinatorial Chemo- and Photodynamic-Therapy of Cancer 
Pandya, Abhilash D.; Øverbye, Anders; Saharia, Priyanka; Gaware, Vivek S.; Høgset, Håkon; Masson, Már; Høgset, Anders; Mælandsmo, Gunhild Mari; Skotland, Tore; Sandvig, Kirsten; Iversen, Tore Geir (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ). The NPs are based on chitosan (CS) conjugate polymers synthesized with ...
Characterization of a Rab-like protein regulating cell migration Restricted Access
Berge, Anne Kristin Mclaren (Master thesis / Masteroppgave, 2020)
Seed based hybridization barriers in Cochlearia 
Kenich, Håkon Muland (Master thesis / Masteroppgave, 2020)
“A cleaner break”: Genetic divergence between geographic groups and sympatric phenotypes revealed in ballan wrasse (Labrus bergylta) 
Seljestad, Gaute; Sanchez, Maria Quintela; Faust, Ellika; Halvorsen, Kim Aleksander Tallaksen; Besnier, Francois; Jansson, Eeva; Dahle, Geir; Knutsen, Halvor; André, Carl; Folkvord, Arild; Glover, Kevin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Capture and long-distance translocation of cleaner fish to control lice infestations on marine salmonid farms has the potential to influence wild populations via overexploitation in source regions, and introgression in ...
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons 
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ...
Allometric relationships in morphological traits associated with foraging, swimming ability, and predator defense reveal adaptations toward brackish and freshwater environments in the threespine stickleback 
Taugbøl, Annette; Quinn, Thomas P.; Østbye, Kjartan; Vøllestad, Leif Asbjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Freshwater colonization by threespine stickleback has led to divergence in morphology between ancestral marine and derived freshwater populations, making them ideal for studying natural selection on phenotypes. In an open ...
A Bayesian Binomial Regression Model with Latent Gaussian Processes for Modelling DNA Methylation 
Hubin, Aliaksandr; Storvik, Geir Olve; Grini, Paul Eivind; Butenko, Melinka Alonso (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Epigenetic observations are represented by the total number of reads from a given pool of cells and the number of methylated reads, making it reasonable to model this data by a binomial distribution. There are numerous ...
Lophiostomataceae and Lophiotremataceae - A phylogenetic and taxonomic study of two ascomycete families. Restricted Access
Andreasen, Mathias (Master thesis / Masteroppgave, 2020)
A phylogenetic analysis of the Crinum rautanenianum complex (Amaryllidaceae) Restricted Access
Uttgaard, Karianne Roti (Master thesis / Masteroppgave, 2020)
Within genus Crinum L. there has been a lot of confusion, especially in the Crinum rautanenianum complex comprising Crinum carolo-schmidtii, C. euchrophyllum, C. paludosum, C. rautanenianum, and also a specimen referred ...
Biologistudenters motivasjon for beregningsorientert biologi etter innføring av krav om full fordypning i realfaglig matematikk 
Eliassen, June Edvarda (Master thesis / Masteroppgave, 2020)
I denne studien ble motivasjonen hos studenter som tok emnet BIOS1100 - innføring i beregningsmodeller i biovitenskap ved Universitetet i Oslo undersøkt. Hovedvekten i studien ble lagt rundt eventuelle effekter krav om ...
Coaggregetion properties of Trimeric Autotransporter Adhesins 
Khalil, Hawzeen S.; Øgaard, Jonas; Leo, Jack Christopher (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Trimeric autotransporter adhesins (TAAs) comprise a group of virulence‐related proteins in Gram‐negative bacteria. Members of this family bind to extracellular matrix components such as collagen and fibronectin, but also ...
Glacier retreat in the High Arctic: Opportunity or threat for ectomycorrhizal diversity? 
Botnen, Synnøve Smebye; Mundra, Sunil; Kauserud, Håvard; Eidesen, Pernille Bronken (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Climate change causes Arctic glaciers to retreat faster, exposing new areas for colonization. Several pioneer plants likely to colonize recent deglaciated, nutrient-poor areas depend on fungal partners for successful ...
Common eider and herring gull as contaminant indicators of different ecological niches of an urban fjord system 
Thorstensen, Helene; Ruus, Anders; Helberg, Morten; Bæk, Kine; Enge, Ellen Katrin; Borgå, Katrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Seabirds like gulls are common indicators in contaminant monitoring. The herring gull (Larus argentatus) is a generalist with a broad range of dietary sources, possibly introducing a weakness in its representativeness of ...
The role of photomineralization for CO2 emissions in boreal lakes along a gradient of dissolved organic matter 
Allesson, Lina; Koehler, Birgit; Thrane, Jan-Erik; Andersen, Tom; Hessen, Dag O (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Many boreal lakes are experiencing an increase in concentrations of terrestrially derived dissolved organic matter (DOM)—a process commonly labeled “browning.” Browning affects microbial and photochemical mineralization ...
In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles 
Stephan, Mareike; Broeker, Nina; Saragliadis, Athanasios; Roos, Norbert; Linke, Dirk; Barbirz, Stefanie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Bacteriophages use a large number of different bacterial cell envelope structures as receptors for surface attachment. As a consequence, bacterial surfaces represent a major control point for the defense against phage ...
LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction 
Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Soedling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann; Sæther, Thomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The cholesterol-sensing nuclear receptor liver X receptor (LXR) and the glucose-sensing transcription factor carbohydrate responsive element-binding protein (ChREBP) are central players in regulating glucose and lipid ...
Congruence, but no cascade—Pelagic biodiversity across three trophic levels in Nordic lakes 
Andersen, Tom; Hessen, Dag Olav; Håll, Johnny Peter; Khomich, Maryia; Kyle, Marcia; Lindholm, Markus; Rasconi, Serena; Skjelbred, Birger; Thrane, Jan-Erik; Walseng, Bjørn (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Covariation in species richness and community structure across taxonomical groups (cross‐taxon congruence) has practical consequences for the identification of biodiversity surrogates and proxies, as well as theoretical ...
Use of salt licks by red deer (Cervus elaphus) in a disease transmission context 
Sørum, Ingrid (Master thesis / Masteroppgave, 2020)
A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease 
Frick, Rahel; Gunnarsen, Kristin Støen; Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Sollid, Ludvig Magne; Sandlie, Inger; Høydahl, Lene Støkken; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Partitioning of persistent hydrophobic contaminants to different storage lipid classes 
Ruus, Anders; Allan, Ian; Bæk, Kine; Borgå, Katrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Lipids generally represent the major matrix contributing to the absorptive capacity for hydrophobic organic contaminants in aquatic ecosystems. The aim of the present study was to determine whether contaminants partition ...
The planktonic protist interactome: where do we stand after a century of research? 
Bjorbækmo, Marit Frederikke Markussen; Evenstad, Andreas; Røsæg, Line Lieblein; Krabberød, Anders Kristian; Logares, Ramiro (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Microbial interactions are crucial for Earth ecosystem function, but our knowledge about them is limited and has so far mainly existed as scattered records. Here, we have surveyed the literature involving planktonic protist ...
The Helvella corium species aggregate in Nordic countries – phylogeny and species delimitation 
Løken, Solveig Bua; Skrede, Inger; Schumacher, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Mycologists have always been curious about the elaborate morphotypes and shapes of species of the genus Helvella. The small, black, cupulate Helvella specimens have mostly been assigned to Helvella corium, a broadly defined ...
RAF kinases are stabilized and required for dendritic cell differentiation and function 
Riegel, Kristina; Schlöder, Janine; Sobczak, Marco; Jonuleit, Helmut; Thiede, Bernd; Schild, Hansjörg; Rajalingam, Krishnaraj (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
RAF kinases (ARAF, BRAF, and CRAF) are highly conserved enzymes that trigger the RAF-MEK1/2-ERK1/2 (MAPK) pathway upon activation of RAS. Despite enormous clinical interest, relatively little is known on the role of RAFs ...
Non‐linearity in interspecific interactions in response to climate change: cod and haddock as an example 
Durant, Joel Marcel; Ono, Kotaro; Stenseth, Nils Christian; Langangen, Øystein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Climate change has profound ecological effects, yet our understanding of how trophic interactions among species are affected by climate change is still patchy. The sympatric Atlantic haddock and cod are co‐occurring across ...
Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets 
Thibau, Arno; Dichter, Alexander A.; Vaca, Diana J.; Linke, Dirk; Goldman, Adrian; Kempf, Volkhard A.J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection ...
Intracellular bacterial pathogens in aquaculture: vaccines and virulence factors 
Rolfsnes, Rebekka Rekkedal (Master thesis / Masteroppgave, 2020)
Fish farming is the most common form of aquaculture. Its production contributes close to 50% of total global fish production, and is estimated to increase to 62% by year 2030. Piscirickettsiosis and francisellosis are two ...
Dissecting biophysical properties of parvalbumin neurons in the primary visual cortex ensheathed by PNNs 
Madland, Tarjei Svanes (Master thesis / Masteroppgave, 2020)
Perineuronal nets (PNNs) are specialized structures of extracellular matrix that are aggregated into mesh-like structures, preferentially ensheathing parvalbumin-expressing (PV+) interneurons. PV+ neurons fire action ...
Marine protected areas rescue a sexually selected trait in European lobster 
Sørdalen, Tonje Knutsen; Halvorsen, Kim Aleksander Tallaksen; Vøllestad, Leif Asbjørn; Moland, Even; Olsen, Esben Moland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Marine protected areas (MPAs) are increasingly implemented worldwide to maintain and restore depleted populations. However, despite our knowledge on the myriad of positive responses to protection, there are few empirical ...
Predominant cleavage of proteins N-terminal to serines and threonines using scandium(III) triflate 
Koehler, Christian; Thiede, Bernd (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Proteolytic digestion prior to LC–MS analysis is a key step for the identification of proteins. Digestion of proteins is typically performed with trypsin, but certain proteins or important protein sequence regions might ...
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