Browsing Det matematisk-naturvitenskapelige fakultet by Author "Dale, Anders M."

Now showing items 1-5 of 5

  • Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model 
    Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Sundar, Vijay S.; Thompson, Paul; Andreassen, Ole Andreas; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. ...
  • Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders 
    Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey; Parker, Nadine; O'Connell, Kevin Sean; Rødevand, Linn; Cheng, Weiqiu; Bahrami, Shahram; Karadag, Naz; Holen, Børge; Jaholkowski, Piotr Pawel; Woldeyohannes, Markos Tesfaye; Djurovic, Srdjan; Dale, Anders M.; Frei, Oleksandr; Ueland, Thor; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ...
  • Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci 
    Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Lin, Aihua; Cheng, Weiqiu; Steen, Nils Eiel; Shadrin, Alexey; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole A.; Smeland, Olav Bjerkehagen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness ...
  • Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci 
    Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos; Bahrami, Shahram; Nerhus, Mari; Rahman, Zillur; O'Connell, Kevin Sean; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; Rødevand, Linn; Karadag, Naz; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. ...
  • Heritability Estimation of Cognitive Phenotypes in the ABCD Study® Using Mixed Models 
    Smith, Diana M.; Loughnan, Robert; Friedman, Naomi P.; Parekh, Pravesh; Frei, Oleksandr; Thompson, Wesley K.; Andreassen, Ole; Neale, Michael; Jernigan, Terry L.; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Twin and family studies have historically aimed to partition phenotypic variance into components corresponding to additive genetic effects ( A ), common environment ( C ), and unique environment ( E ). Here we ...