dc.date.accessioned | 2015-04-13T18:13:11Z | |
dc.date.available | 2015-04-13T18:13:11Z | |
dc.date.created | 2014-08-22T12:46:38Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Askautrud, Hanne Arenberg Gjernes, Elisabet Gunnes, Gjermund Sletten, Marit Ross, D. T. Børresen-Dale, Anne-Lise Iversen, Nina Tranulis, Michael A. Frengen, Eirik . Global Gene Expression Analysis Reveals a Link between NDRG1 and Vesicle Transport. PLoS ONE. 2014, 9(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/43550 | |
dc.description.abstract | N-myc downstream-regulated gene 1 (NDRG1) is induced by cellular stress such as hypoxia and DNA damage, and in humans, germ line mutations cause Charcot-Marie-Tooth disease. However, the cellular roles of NDRG1 are not fully understood. Previously, NDRG1 was shown to mediate doxorubicin resistance under hypoxia, suggesting a role for NDRG1 in cell survival under these conditions. We found decreased apoptosis in doxorubicin-treated cells expressing NDRG1 shRNAs under normoxia, demonstrating a requirement for NDRG1 in apoptosis in breast epithelial cells under normal oxygen pressure. Also, different cellular stress regimens, such as hypoxia and doxorubicin treatment, induced NDRG1 through different stress signalling pathways. We further compared expression profiles in human breast epithelial cells ectopically over-expressing NDRG1 with cells expressing NDRG1 shRNAs in order to identify biological pathways where NDRG1 is involved. The results suggest that NDRG1 may have roles connected to vesicle transport. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Public Library of Science (PLoS) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Global Gene Expression Analysis Reveals a Link between NDRG1 and Vesicle Transport | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Askautrud, Hanne Arenberg | |
dc.creator.author | Gjernes, Elisabet | |
dc.creator.author | Gunnes, Gjermund | |
dc.creator.author | Sletten, Marit | |
dc.creator.author | Ross, D. T. | |
dc.creator.author | Børresen-Dale, Anne-Lise | |
dc.creator.author | Iversen, Nina | |
dc.creator.author | Tranulis, Michael A. | |
dc.creator.author | Frengen, Eirik | |
cristin.unitcode | 185,53,18,10 | |
cristin.unitname | Avdeling for medisinsk genetikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1148766 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=PLoS ONE&rft.volume=9&rft.spage=&rft.date=2014 | |
dc.identifier.jtitle | PLoS ONE | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0087268 | |
dc.identifier.urn | URN:NBN:no-47921 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1932-6203 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/43550/1/journal-pone-0087268frengen.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e87268 | |