dc.date.accessioned | 2015-02-25T13:24:25Z | |
dc.date.available | 2015-02-25T13:24:25Z | |
dc.date.created | 2014-08-18T12:16:37Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Søraas, Arne Vasli Lund Olsen, Ingar Sundsfjord, Arnfinn Handal, Trude Bjørang, Ola Jenum, Pål . Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae. Journal of Oral Microbiology. 2014, 6 | |
dc.identifier.uri | http://hdl.handle.net/10852/42560 | |
dc.description.abstract | Background: The prevalence of infections caused by Cefotaximase-Munich (CTX-M)-type extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) has rapidly increased during the past 15 years. Enterobacteriaceae are commonly found in the gastrointestinal tract and long-term intestinal carriage is considered important for the spread of ESBL and as a source of clinical infections. Oral biofilm such as supragingival plaque is known to contain numerous antibiotic resistance determinants and may also represent a poorly investigated site for ESBL carriage and further spread.
Objective: To investigate possible carriage of ESBL-producing bacteria in supragingival plaque of known fecal carriers of these bacteria.
Design: We screened for the presence of aerobic and anaerobic ESBL-producing bacteria and blaCTX-M in supragingival plaque samples from healthy human adults with culture-verified fecal carriage of CTX-M-producing Escherichia coli. The presence or absence of Enterobacteriaceae and ESBL-producing bacteria in plaque samples was evaluated using culture-based methods and consensus CTX-M PCR.
Results: Oral samples were obtained from 17 participants with known previous carriage of ESBL-producing E. coli. No ESBL-producing bacteria or ESBL genes were detected using culture-based and molecular methods. One colony of Rahnella aquatilis harboring the class A ESBL gene blaRAHN-1/2 was identified in an oral sample from one of the participants.
Conclusion: This pilot study supports the notion that the presence of CTX-M-producing bacteria is uncommon in oral plaque of healthy human adult fecal carriers. Due to the limited number of persons tested, a low prevalence of oral ESBL-carriage in healthy adults or carriage in selected groups of patients cannot be excluded. To our knowledge, this is the first description of an R. aquatilis with the RAHN-1/2 gene in the oral cavity. | en_US |
dc.language | EN | |
dc.language.iso | en | en_US |
dc.publisher | Co-Action Publishing | |
dc.rights | Attribution-NonCommercial 3.0 Unported | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | |
dc.title | Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae | en_US |
dc.type | Journal article | en_US |
dc.creator.author | Søraas, Arne Vasli Lund | |
dc.creator.author | Olsen, Ingar | |
dc.creator.author | Sundsfjord, Arnfinn | |
dc.creator.author | Handal, Trude | |
dc.creator.author | Bjørang, Ola | |
dc.creator.author | Jenum, Pål | |
cristin.unitcode | 185,16,15,0 | |
cristin.unitname | Institutt for oral biologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1147546 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Oral Microbiology&rft.volume=6&rft.spage=&rft.date=2014 | |
dc.identifier.jtitle | Journal of Oral Microbiology | |
dc.identifier.volume | 6 | |
dc.identifier.pagecount | 7 | |
dc.identifier.doi | http://dx.doi.org/10.3402/jom.v6.24026 | |
dc.identifier.urn | URN:NBN:no-46964 | |
dc.type.document | Tidsskriftartikkel | en_US |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2000-2297 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/42560/1/24026-132745-1-PB.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 24026 | |