Browsing Institutt for klinisk medisin by Author "Xavier, Ramnik J."

Now showing items 1-5 of 5

  • An integrative genomics approach identifies KDM4 as a modulator of trained immunity 
    Moorlag, Simone J.C.F.M.; Matzaraki, Vasiliki; van Puffelen, Jelmer H.; van der Heijden, Charlotte; Keating, Sam; Groh, Laszlo; Röring, Rutger Jan; Bakker, Olivier B.; Mourits, Vera P.; Koeken, Valerie A.C.M.; de Bree, L. Charlotte J.; Smeekens, Sanne P.; Oosting, Marije; Gamboa, Raúl Aguirre; Riksen, Niels P.; Xavier, Ramnik J.; Wijmenga, Tjitske Nienke (Cisca); Mishra, Vinod Kumar; van Crevel, Reinout; Novakovic, B.; Joosten, Leo A.B.; Li, Yang; Netea, Mihai G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Innate immune cells are able to build memory characteristics via a process termed “trained immunity.” Host factors that influence the magnitude of the individual trained immunity response remain largely unknown. Using an ...
  • Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease 
    Goel, Gautam; Tye-Din, Jason A.; Qiao, Shuo Wang; Russell, Amy K.; Mayassi, Toufic; Ciszewski, Cezary; Sarna, Vikas Kumar; Wang, Suyue; Goldstein, Kaela E.; Dzuris, John L.; Williams, Leslie J.; Xavier, Ramnik J.; Lundin, Knut Erik Aslaksen; Jabri, Bana; Sollid, Ludvig Magne; Anderson, Robert P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Celiac disease (CeD), caused by immune reactions to cereal gluten, is treated with gluten -elimination diets. Within hours of gluten exposure, either perorally or extraorally by intradermal injection, treated patients ...
  • Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies 
    Goel, Gautam; King, Tim; Daveson, A. James; Andrews, Jane M.; Krishnarajah, Janakan; Krause, Richard; Brown, Gregor J.E.; Fogel, Ronald; Barish, Charles F.; Epstein, Roger; Kinney, Timothy P.; Miner, Philip B.; Tye-Din, Jason A.; Girardin, Adam; Taavela, Juha; Popp, Alina; Sidney, John; Mäki, Markku; Goldstein, Kaela E.; Griffin, Patrick H.; Wang, Suyue; Dzuris, John L.; Williams, Leslie J.; Sette, Alessandro; Xavier, Ramnik J.; Sollid, Ludvig Magne; Jabri, Bana; Anderson, Robert P. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    Background: A gluten-free diet is the only means to manage coeliac disease, a permanent immune intolerance to gluten. We developed a therapeutic vaccine, Nexvax2, designed to treat coeliac disease. Nexvax2 is an adjuvant-free ...
  • Identification of trypsin-degrading commensals in the large intestine 
    Li, Youxian; Watanabe, Eiichiro; Kawashima, Yusuke; Plichta, Damian R.; Wang, Zhujun; Ujike, Makoto; Ang, Qi Yan; Wu, Runrun; Furuichi, Munehiro; Takeshita, Kozue; Yoshida, Koji; Nishiyama, Keita; Kearney, Sean M.; Suda, Wataru; Hattori, Masahira; Sasajima, Satoshi; Matsunaga, Takahiro; Zhang, Xiaoxi; Watanabe, Kazuto; Fujishiro, Jun; Norman, Jason M.; Olle, Bernat; Matsuyama, Shutoku; Namkoong, Ho; Uwamino, Yoshifumi; Ishii, Makoto; Fukunaga, Koichi; Hasegawa, Naoki; Ohara, Osamu; Xavier, Ramnik J.; Atarashi, Koji; Honda, Kenya (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions 1–3 . However, the players and mechanisms that underlie protease regulation in the ...
  • Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease 
    Chu, Xiaojing; Jaeger, Martin; Beumer, Joep; Bakker, Olivier B.; Aguirre-Gamboa, Raul; Oosting, Marije; Smeekens, Sanne P.; Moorlag, Simone; Mourits, Vera P.; Koeken, Valerie A. C. M.; de Bree, Charlotte; Jansen, Trees; Mathews, Ian T.; Dao, Khoi; Najhawan, Mahan; Watrous, Jeramie D.; Joosten, Irma; Sharma, Sonia; Koenen, Hans J. P. M.; Withoff, Sebo; Jonkers, Iris H.; Netea-Maier, Romana T.; Xavier, Ramnik J.; Franke, Lude; Xu, Cheng-Jian; Joosten, Leo A. B.; Sanna, Serena; Jain, Mohit; Kumar, Vinod; Clevers, Hans; Wijmenga, Cisca; Netea, Mihai G.; Li, Yang (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. ...