Browsing Institutt for klinisk medisin by Author "Paarmann, Kristin"

Now showing items 1-4 of 4

  • Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice 
    Rai, Surya Prakash; Bascuñana, Pablo; Brackhan, Mirjam; Krohn, Markus; Möhle, Luisa; Paarmann, Kristin; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background: The recent failure of clinical trials to treat Alzheimer’s disease (AD) indicates that the current approach of modifying disease is either wrong or is too late to be efficient. Mild cognitive impairment (MCI) ...
  • Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice 
    Steffen, Johannes; Krohn, Markus; Schwitlick, Christina; Brüning, Thomas; Paarmann, Kristin; Pietrzik, Claus U; Biverstål, Henrik; Jansone, Baiba; Langer, Oliver; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts ...
  • Generation and characterization of an ABCC1 humanized mouse model (HABCC1<sup>FLX/FLX</sup>) with knockout capability 
    Krohn, Markus; Zoufal, Viktoria; Mairinger, Severin; Wanek, Thomas; Paarmann, Kristin; Brüning, Thomas; Eiriz Delgado, Iván; Brackhan, Mirjam; Langer, Oliver; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    ATP-binding cassette (ABC) transporters such as ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP) are well known for their role in rendering cancer cells resistant to chemotherapy. Additionally, recent research provided ...
  • Revisiting rodent models: Octodon degus as Alzheimer’s disease model? 
    Steffen, Johannes; Krohn, Markus; Paarmann, Kristin; Schwitlick, Christina; Brüning, Thomas; Marreiros, Rita; Müller-Schiffmann, Andreas; Korth, Carsten; Braun, Katharina; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Alzheimer’s disease primarily occurs as sporadic disease and is accompanied with vast socio-economic problems. The mandatory basic research relies on robust and reliable disease models to overcome increasing incidence and ...