Browsing Institutt for klinisk medisin by Author "Fan, Chun-Chieh"

Now showing items 1-7 of 7

  • Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model 
    Holland, Dominic; Frei, Oleksandr; Desikan, Rahul S.; Fan, Chun-Chieh; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Sundar, Vijay S.; Thompson, Paul; Andreassen, Ole Andreas; Dale, Anders M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is currently of considerable interest. ...
  • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 
    Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and ...
  • Large-scale genomics unveil polygenic architecture of human cortical surface area 
    Chen, Chi-Hua; Peng, Qian; Schork, Andrew J.; Lo, Min-Tzu; Fan, Chun-Chieh; Wang, Yunpeng; Desikan, Rahul S.; Bettella, Franscesco; Hagler, Donald J.; Westlye, Lars Tjelta; Kremen, William S.; Jernigan, Terry L.; Le Hellard, Stephanie; Steen, Vidar Martin; Espeseth, Thomas; Huentelman, Matt; Håberg, Asta; Agartz, Ingrid; Djurovic, Srdjan; Andreassen, Ole Andreas; Schork, Nicholas; Dale, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ...
  • Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex 
    Li, Yi; Barkovich, Matthew J.; Karch, Celeste M.; Nillo, Ryan M.; Fan, Chun-Chieh; Broce, Iris J.; Tan, Chin Hong; Cuneo, Daniel; Hess, Christopher P.; Dillon, William P.; Glenn, Orit A.; Glastonbury, Christine M.; Olney, Nicholas; Yokoyama, Jennifer S.; Bonham, Luke W.; Miller, Bruce; Kao, Aimee; Schmansky, Nicholas; Fischl, Bruce; Andreassen, Ole Andreas; Jernigan, Terry; Dale, Anders; Barkovich, A. James; Desikan, Rahul S.; Sugrue, Leo P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Tuberous sclerosis complex (TSC), a heritable neurodevelopmental disorder, is caused by mutations in the TSC1 or TSC2 genes. To date, there has been little work to elucidate regional TSC1 and TSC2 gene expression within ...
  • RICOPILI: Rapid Imputation for COnsortias PIpeLIne 
    Lam, Max; Awasthi, Swapnil; Watson, Hunna J.; Goldstein, Jackie; Panagiotaropoulou, Georgia; Trubetskoy, Vassily; Karlsson, Robert; Frei, Oleksandr; Fan, Chun-Chieh; De Witte, Ward; Mota, Nina R.; Brugger, Kim; Lee, S. Hong; Wray, Naomi R.; Skarabis, Nora; Huang, Hailiang; Neale, Benjamin M.; Daly, Mark J.; Mattheisen, Manuel; Walters, Raymond K.; Ripke, Stephan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Genome-wide association study (GWAS) analyses, at sufficient sample sizes and power, have successfully revealed biological insights for several complex traits. RICOPILI, an open-sourced Perl-based pipeline was developed ...
  • Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood 
    Cheng, Weiqiu; van der Meer, Dennis; Parker, Nadine; Hindley, Guy Frederick Lanyon; O'Connell, Kevin Sean; Wang, Yunpeng; Shadrin, Alexey; Alnæs, Dag; Bahrami, Shahram; Lin, Aihua; Karadag, Naz; Holen, Børge; Fernández-Cabello, Sara; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Westlye, Lars Tjelta; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the genetic relationship between schizophrenia and brain volumetric ...
  • The emerging pattern of shared polygenic architecture of psychiatric disorders, conceptual and methodological challenges 
    Smeland, Olav Bjerkehagen; Frei, Oleksandr; Fan, Chun-Chieh; Shadrin, Alexey A.; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Genome-wide association studies have transformed psychiatric genetics and provided novel insights into the genetic etiology of psychiatric disorders. Two major discoveries have emerged; the disorders are polygenic, with a ...