Browsing Institutt for klinisk medisin by Author "D'Ambrosio, Chiara"

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  • APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation 
    Lirussi, Lisa; Antoniali, Giulia; D'Ambrosio, Chiara; Scaloni, Andrea; Nilsen, Hilde; Tell, Gianluca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Apurinic/apyrimidinic endonuclease 1 (APE1) is the main mammalian AP-endonuclease responsible for the repair of endogenous DNA damage through the base excision repair (BER) pathway. Molecular epidemiological studies have ...
  • Cleavage of the APE1 N-terminal domain in acute myeloid leukemia cells is associated with proteasomal activity 
    Lirussi, Lisa; Antoniali, Giulia; Scognamiglio, Pasqualina Liana; Marasco, Daniela; Dalla, Emiliano; D'Ambrosio, Chiara; Arena, Simona; Scaloni, Andrea; Tell, Gianluca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Apurinic/apyrimidinic endonuclease 1 (APE1), the main mammalian AP-endonuclease for the resolution of DNA damages through the base excision repair (BER) pathway, acts as a multifunctional protein in different key cellular ...
  • Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism 
    Antoniali, Giulia; Serra, Fabrizio; Lirussi, Lisa; Tanaka, Mikiei; D'Ambrosio, Chiara; Zhang, Shiheng; Radovic, Slobodanka; Dalla, Emiliano; Ciani, Yari; Scaloni, Andrea; Li, Mengxia; Piazza, Silvano; Tell, Gianluca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular ...