Browsing Institutt for klinisk medisin by Author "Caddy, Sarah L."

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  • Complement C4 prevents viral infection through capsid inactivation 
    Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James Kennedy; O'Connell, Kevin; Clark, Jessica; Mayes, Keith; Higginson, Katie; Lode, Heidrun Elisabeth; McAdam, Martin Berner; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering ...
  • Intracellular neutralisation of rotavirus by VP6-specific IgG 
    Caddy, Sarah L.; Vaysburd, Marina; Wing, Mark; Foss, Stian; Andersen, Jan Terje; O'Connell, Kevin; Mayes, Keith; Higginson, Katie; Iturriza-Gómara, Miren; Desselberger, Ulrich; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 ...
  • Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity 
    Caddy, Sarah L.; Vaysburd, Marina; Papa, Guido; Wing, Mark; O'Connell, Kevin; Stoycheva, Diana; Foss, Stian; Andersen, Jan Terje; Oxenius, Annette; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Nucleoprotein (N) is an immunodominant antigen in many enveloped virus infections. While the diagnostic value of anti‐N antibodies is clear, their role in immunity is not. This is because while they are non‐neutralising, ...