Browsing Institutt for klinisk medisin by Title

Now showing items 6460-6479 of 10888

  • Molecular biological examination of somatotroph pituitary adenomas related to clinical data from patients with acromegaly 
    Fougner, Stine Lyngvi (Doctoral thesis / Doktoravhandling, 2010)
    Definition and epidemiology<br> The first historical description of acromegaly could be the story of David and Goliath described both in The Old Testament and in the Koran. Goliath was a giant, but David defeated him by ...
  • Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy 
    Haakensen, Vilde Drageset; Khadse, Anand; Sandhu, Vandana; Halvorsen, Ann Rita; Solberg, Steinar; Jørgensen, Lars Hilmar; Brustugun, Odd Terje; Kure, Elin Wenche Hegland; Helland, Åslaug (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Personalised cancer treatment depends on identification of therapeutically relevant biological subgroups of patients for assessing effect of treatment and to discover new therapeutic options. By analyses in heterogeneous ...
  • Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden 
    Hua, Ying; Bai, Xiangning; Zhang, Ji; Jernberg, Cecilia; Chromek, Milan; Hansson, Sverker; Frykman, Anne; Yang, Xi; Xiong, Yanwen; Wan, Chengsong; Matussek, Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, ...
  • Molecular characteristics of Staphylococcus aureus associated prosthetic joint infections after hip fractures treated with hemiarthroplasty: a retrospective genome-wide association study 
    Noone, John Christopher; Stegger, Marc; Lilje, Berit; Stavem, Knut; Helmersen, Karin; Skråmm, Inge; Aamot, Hege Vangstein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract A retrospective study of Staphylococcus aureus isolates from orthopaedic patients treated between 2000 and 2017 at Akershus University Hospital, Norway was performed using a genome-wide association approach. ...
  • Molecular characterization of carcinosarcomas arising in the uterus and ovaries 
    Brunetti, Marta; Agostini, Antonio; Staurseth, Julie; Davidson, Ben; Heim, Sverre; Micci, Francesca (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Gynaecological carcinosarcomas are rare biphasic tumours which are highly aggressive. We performed molecular investigations on a series of such tumours arising in the uterus (n = 16) and ovaries (n = 10) to gain more ...
  • Molecular characterization of the enterohemolysin gene (ehxA) in clinical Shiga toxin-producing Escherichia coli isolates 
    Hua, Ying; Zhang, Ji; Jernberg, Cecilia; Chromek, Milan; Hansson, Sverker; Frykman, Anne; Xiong, Yanwen; Wan, Chengsong; Matussek, Andreas; Bai, Xiangning (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Shiga toxin (Stx)-producing Escherichia coli (STEC) is an important foodborne pathogen with the ability to cause bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Little is known about enterohemolysin-encoded by ...
  • Molecular classification of breast carcinomas 
    Russnes, Hege (Doctoral thesis / Doktoravhandling, 2010)
    The acknowledged heterogeneity of breast cancer both at the clinical and at the molecular level has been a challenge in classification of breast cancer. This study aimed at identifying distinct molecular subgroups of the ...
  • Molecular Communication Aspects of Potassium Intracellular Signaling in Cardiomyocytes 
    Lu, Pengfei; Veletic, Mladen; Bergsland, Jacob; Balasingham, Ilangko (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Cardiovascular diseases continue to be a leading cause of morbidity and mortality worldwide. Cardiomyocytes, as the elementary heart components, play a crucial role in maintaining a healthy heart by coordinating contractions ...
  • Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity 
    Smeby, Jørgen; Kryeziu, Kushtrim; Berg, Kaja Christine Graue; Eilertsen, Ina Andrassy; Eide, Peter Andreas Wold; Johannessen, Bjarne; Guren, Marianne; Nesbakken, Arild; Bruun, Jarle; Lothe, Ragnhild A; Sveen, Anita (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well studied. Methods Mutations and genome-wide ...
  • Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer? 
    Kristensen, Annette T; Wiig, Johan N; Larsen, Stein G; Giercksky, Karl-Erik; Ekstrøm, Per O (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Background After total mesorectal excision (TME) for rectal cancer around 10% of patients develops local recurrences within the pelvis. One reason for recurrence might be spillage of cancer cells during ...
  • Molecular Detection of Borrelia Bacteria in Cerebrospinal Fluid-Optimisation of Pre-Analytical Sample Handling for Increased Analytical Sensitivity 
    Lager, Malin; Wilhelmsson, Peter; Matussek, Andreas Albert; Lindgren, Per-Eric; Henningsson, Anna J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The main tools for clinical diagnostics of Lyme neuroborreliosis (LNB) are based on serology, i.e., detection of antibodies in cerebrospinal fluid (CSF). In some cases, PCR may be used as a supplement, e.g., on CSF from ...
  • Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe. 
    Benschop, Kimberley; Broberg, Eeva; Hodcroft, E; Schmitz, D; Albert, Jan; Baicus, A; Bailly, Jean-Luc; Baldvinsdottir, Gudrun; Berginc, N; Blomqvist, S; Böttcher, S; Brytting, M; Bujaki, Erika; Cabrerizo, Maria; Celma, Cristina; Cinek, Ondrej; Claas, Eric CJ; Cremer, Jeroen; Dean, Jonathan; Dembinski, Jennifer Lynn; Demchyshyna, Iryna; Diedrich, Sabine; Dudman, Susanne Gjeruldsen; Dunning, Jake; Dyrdak, Robert; Emmanouil, Mary; Farkas, Agnes; De Gascun, Cillian; Fournier, Guillaume; Georgieva, Irina; Gonzalez-Sanz, Ruben; van Hooydonk-Elving, Jolanda; Jääskeläinen, A. J.; Jancauskaite, Ruta; Keeren, Kathrin; Fischer, Thea Kølsen; Krokstad, Sidsel; Nikolaeva–Glomb, Lubomira; Novakova, Ludmila; Midgley, SE; Mirand, Audrey; Molenkamp, Richard; Morley, Ursula; Mossong, Joël; Muralyte, Svajune; Murk, Jean-Luc; Nguyen, Trung; Nordbø, Svein Arne; Österback, Riikka; Pas, Suzan; Pellegrinelli, Laura; Pogka, Vassiliki; Prochazka, Birgit; Rainetova, Petra; Van Ranst, Marc; Roorda, Lieuwe; Schuffenecker, Isabelle; Schuurman, Rob; Stoyanova, Asya; Templeton, Kate E.; Verweij, Jaco J.; Voulgari-Kokota, Androniki; Vuorinen, Tytti; Wollants, Elke; Wolthers, Katja; Zakikhany, Katherina; Neher, Richard; Harvala, Heli; Simmonds, Peter (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most ...
  • Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer 
    Lesurf, Robert; Aure, Miriam Ragle; Mørk, Hanne Håberg; Vitelli, Valeria; Lundgren, Steinar; Børresen-Dale, Anne-Lise; Kristensen, Vessela N.; Wärnberg, Fredrik; Hallett, Michael; Sørlie, Therese (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of ...
  • Molecular Genetic Characterization of Acute Myeloid Leukemia With Trisomy 4 as the Sole Chromosome Abnormality 
    Torkildsen, Synne; Gorunova, Ludmila; Heim, Sverre; Tjønnfjord, Geir Erland; Spetalen, Signe; Risberg, Bente; Tran, Hoa Thi Tuyet; Panagopoulos, Ioannis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background/Aim: The aim of the study was to determine the genetic and molecular consequences of trisomy 4, a recurrent but rare chromosomal abnormality in acute myeloid leukemia (AML). Materials and Methods: Interphase ...
  • Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: A report from the Cognitive Genomics consorTium (COGENT) 
    Lencz, T; Knowles, Emily; Davies, G; Guha, S; Liewald, DC; Starr, JM; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; Mukherjee, Sayan; Derosse, P; Lundervold, Arvid; Steen, Vidar Martin; Espeseth, Thomas; John, M.; Räikkönen, K; Widen, E; Palotie, A; Eriksson, JG; Giegling, I; Konte, B; Ikeda, M; Roussos, P; Giakoumaki, S; Burdick, KE; Payton, A.; Ollier, W; Horan, M.; Donohoe, G; Morris, D; Corvin, A; Gill, M; Pendleton, N; Iwata, N; Darvasi, A; Bitsios, P; Rujescu, D; Lahti, J; Le Hellard, Stephanie; Keller, MC; Andreassen, Ole Andreas; Deary, IJ; Glahn, DC; Malhotra, AK (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ...
  • Molecular imaging in atherosclerosis 
    Bassir, Ali; Raynor, William Y.; Park, Peter Sang Uk; Werner, Thomas J.; Alavi, Abass; Rootwelt-Revheim, Mona Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Purpose As atherosclerosis is a prominent cause of morbidity and mortality, early detection of atherosclerotic plaques is vital to prevent complications. Imaging plays a significant role in this goal. Molecular imaging and ...
  • Molecular mechanisms controlling endocytic downregulation of EGFR and ErbB3 
    Sak, Malgorzata Magdalena (Doctoral thesis / Doktoravhandling, 2013)
    ErbB proteins are a family of receptor tyrosine kinases that includes epidermal growth factor receptor (EGFR), ErbB2, ErbB3 and ErbB4. ErbB proteins govern many physiological processes during development and in an adult ...
  • Molecular Mechanisms in Heart Failure : The Role of Syndecan-4 in Development of Myocardial Hypertrophy and Heart Failure 
    Finsen, Alexandra Vanessa (Doctoral thesis / Doktoravhandling, 2008)
    The prevalence of congestive heart failure (CHF) is increasing dramatically world-wide. Sustained myocardial hypertrophy is an important risk factor for developing CHF, but the underlying mechanisms initiating and maintaining ...
  • Molecular mechanisms of atherosclerotic disease: Studies on the role of the DNA glycosylase NEIL3 and the epitranscriptome in the development of atherosclerosis 
    Quiles-Jiménez, Ana María (Doctoral thesis / Doktoravhandling, 2020)
    Cardiovascular diseases are one of the top causes of mortality worldwide, and the main underlying cause is atherosclerosis. Atherosclerosis is a multifactorial and progressive arterial disease where lipid accumulation and ...
  • Molecular mechanisms of heart failure : Nuclear Factor of Activated T-cell (NFAT) signaling in myocardial hypertrophy and dysfunction 
    Lunde, Ida Gjervold (Doctoral thesis / Doktoravhandling, 2012)