Browsing Institutt for klinisk medisin by Title
Now showing items 6440-6459 of 10874
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Abstract γδ T cells play a pivotal role in protection against various types of infections and tumours, from early childhood on and throughout life. They consist of several subsets characterised by adaptive and innate-like ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)The compound EACC (ethyl (2-(5-nitrothiophene-2-carboxamido) thiophene-3-carbonyl) carbamate) was recently reported to inhibit fusion of autophagosomes with lysosomes in a reversible manner by inhibiting recruitment of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Investigating and understanding the response of microbes to various surfaces requires a versatile parametrisation of the surface, and multiple assays that captures the complexity of the biofilm structures. Here, Staphylococcus ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background: The combination of eating disorder (ED) and the experience of childhood trauma leads to significant impairment and suffering. To improve treatment, it is critically important to study treatment effects, and the ...
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(Doctoral thesis / Doktoravhandling, 2013)
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(Doctoral thesis / Doktoravhandling, 2023)Duchenne muscular dystrophy (DMD) is a rare, progressive neuromuscular disorder that mainly affects boys. Symptoms present in early childhood and life expectancy is severely reduced. Long-term treatment with glucocorticoids ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background: As new gene-related treatment options for Duchenne muscular dystrophy (DMD) are being developed, precise information about the patients’ genetic diagnosis and knowledge about the diversities of natural history ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)The prevalence of carbapenemase-producing Enterobacteriaceae (CPE) is increasing worldwide. Here we present associated patient data and molecular, epidemiological and phenotypic characteristics of all CPE isolates in Norway ...
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(Doctoral thesis / Doktoravhandling, 2016)
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(Doctoral thesis / Doktoravhandling, 2021)Colorectal cancer is a common cancer in both genders, and 50% develop metastases which is the dominating cause of death from CRC, most frequently located in the liver (CLM). Only 20% of patients with CLM are eligible for ...
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(Journal article / Tidsskriftartikkel / Published version; Peer reviewed, 2014)Cardiac sodium (Na+)-calcium (Ca2+) exchanger 1 (NCX1) is central to the maintenance of normal Ca2+ homeostasis and contraction. Studies indicate that the Ca2+-activated protease calpain cleaves NCX1. We hypothesized that ...
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(Doctoral thesis / Doktoravhandling, 2010)Definition and epidemiology<br> The first historical description of acromegaly could be the story of David and Goliath described both in The Old Testament and in the Koran. Goliath was a giant, but David defeated him by ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Personalised cancer treatment depends on identification of therapeutically relevant biological subgroups of patients for assessing effect of treatment and to discover new therapeutic options. By analyses in heterogeneous ...
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Molecular characteristics of eae-positive clinical Shiga toxin-producing Escherichia coli in Sweden (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Shiga toxin (Stx)-producing Escherichia coli (STEC) can cause a wide range of symptoms from asymptomatic carriage, mild diarrhea to bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Intimin, encoded by the eae gene, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Abstract A retrospective study of Staphylococcus aureus isolates from orthopaedic patients treated between 2000 and 2017 at Akershus University Hospital, Norway was performed using a genome-wide association approach. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Gynaecological carcinosarcomas are rare biphasic tumours which are highly aggressive. We performed molecular investigations on a series of such tumours arising in the uterus (n = 16) and ovaries (n = 10) to gain more ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Shiga toxin (Stx)-producing Escherichia coli (STEC) is an important foodborne pathogen with the ability to cause bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Little is known about enterohemolysin-encoded by ...
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(Doctoral thesis / Doktoravhandling, 2010)The acknowledged heterogeneity of breast cancer both at the clinical and at the molecular level has been a challenge in classification of breast cancer. This study aimed at identifying distinct molecular subgroups of the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Cardiovascular diseases continue to be a leading cause of morbidity and mortality worldwide. Cardiomyocytes, as the elementary heart components, play a crucial role in maintaining a healthy heart by coordinating contractions ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well studied. Methods Mutations and genome-wide ...