Browsing Institutt for klinisk medisin by Title

Now showing items 2959-2978 of 10888

  • Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence 
    Lekva, Tove; Roland, M.C.P.; Estensen, M.E.; Norwitz, Errol R.; Tilburgs, T.; Henriksen, Tore; Bollerslev, Jens; Normann, K.R.; Magnus, P.; Olstad, Ole Kristoffer; Aukrust, Pål; Ueland, T. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Senescence in placenta/fetal membranes is a normal phenomenon linked to term parturition. However, excessive senescence which may be induced by telomere attrition, has been associated with preeclampsia (PE). We ...
  • Dysregulation of circulating autoantibodies against VEGF-A, VEGFR-1 and PlGF in preeclampsia ? A role in placental and vascular health? 
    Moe, Kjartan; Heidecke, Harald; Dechend, Ralf; Staff, Anne Cathrine (Journal article / Tidsskriftartikkel / SubmittedVersion, 2017)
    Objectives: Preeclampsia is a state of antiangiogenesis, with high levels of maternal circulating sVEGFR-1 (soluble vascular endothelial growth factor receptor 1, also named sFlt1) and low levels of PlGF (placenta growth ...
  • Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes 
    Lavelle, Timothy J; Alver, Tine Norman; Heintz, Karen Marie; Wernhoff, Patrik; Nygaard, Vegard; Nakken, Sigve; Øy, Geir Frode; Bøe, Sigurd; Urbanucci, Alfonso; Hovig, Eivind (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The MC1R/cAMP/MITF pathway is a key determinant for growth, differentiation, and survival of melanocytes and melanoma. MITF-M is the melanocyte-specific isoform of Microphthalmia-associated Transcription Factor (MITF) in ...
  • Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation 
    Skogseid, Inger M; Røsby, Oddveig; Konglund, Ane; Connelly, James P; Nedregaard, Bård; Jablonski, Greg E; Kvernmo, Nadja; Stray-Pedersen, Asbjørg; Glover, Joel C (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Dystonia-deafness syndrome is a well-known clinical entity, with sensorineural deafness typically manifesting earlier than dystonia. ACTB p.Arg183Trp heterozygosity has been reported in six ...
  • Død av overdose, men ukjent for hjelpeapparatet: Hva karakteriserer personer som dør av overdose og ikke har hatt kontakt med hjelpeapparatet?Restricted Access 
    Bonnier, Martine Lepsøy (Master thesis / Masteroppgave, 2016)
    Bakgrunn: Dødelighet blant rusmiddelavhengige ansees som et stort helseproblem i Europa. Den høye dødeligheten skyldes blant annet overdosedødsfall. Norge er et av de landene med høyest antall overdosedødsfall i forhold ...
  • Dødsfall assosiert med MDMA i perioden 2000–19 
    Jamt, Ragnhild Elén Gjulem; Edvardsen, Hilde Marie Erøy; Middelkoop, Gerrit; Allevik, Anna S.K; Bogstrand, Stig Tore; Vevelstad, Merete; Vindenes, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    BAKGRUNN Bruk av MDMA (3,4-metylendioksymetamfetamin), også kjent som ecstasy, har økt i Norge de senere år. Ettersom MDMA potensielt kan være toksisk og forårsake dødsfall, har vi undersøkt om økt tilgjengelighet og ...
  • Dødsfall i sykehjem etter covid-19-vaksine 
    Wyller, Torgeir Bruun; Kittang, Bård Reiakvam; Ranhoff, Anette Hylen; Harg, Pernille; Myrstad, Marius (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    BAKGRUNN I perioden 27.12.2020–15.2.2021 ble om lag 29 400 av Norges ca. 35 000 sykehjemspasienter vaksinert med mRNA-vaksinen BNT162b2. I samme tidsrom mottok Statens legemiddelverk 100 meldinger om mistenkte fatale ...
  • E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models 
    Bruun, Jarle; Eide, Peter Andreas Wold; Bergsland, Christian Holst; Brück, Oscar; Svindland, Aud; Arjama, Mariliina; Välimäki, Katja; Bjørnslett, Merete Pauline; Guren, Marianne; Kallioniemi, Olli; Nesbakken, Arild; Lothe, Ragnhild Adelheid; Pellinen, Teijo Severi (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Cell–cell and cell–matrix adhesion proteins that have been implicated in colorectal epithelial integrity and epithelial-to-mesenchymal transition could be robust prognostic and potential predictive biomarkers for standard ...
  • EACVI survey on investigations and imaging modalities in chronic coronary syndromes 
    Bularga, Anda; Saraste, Antti; Fontes-Carvalho, Ricardo; Holte, Espen; Cameli, Matteo; Michalski, Blazej; Williams, Michelle C.; Podlesnikar, Tomaz; D'Andrea, Antonello; Stankovic, Ivan; Mills, Nicholas L.; Manka, Robert; Newby, David E.; Schultz-Menger, Jeanette; Haugaa, Kristina; Dweck, Mark R. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Aims The European Association of Cardiovascular Imaging (EACVI) Scientific Initiatives Committee performed a global survey to evaluate current practice for the assessment and ...
  • EACVI survey on multimodality training in ESC countries 
    Cameli, Matteo; Marsan, Nina Ajmone; D'Andrea, Antonello; Dweck, Mark R.; Fontes-Carvalho, Ricardo; Manka, Robert; Michalski, Blazej; Podlesnikar, Tomaz; Sitges, Marta; Popescu, Bogdan A.; Edvardsen, Thor; Fox, Kevin F.; Haugaa, Kristina (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    One of the missions of the European Association of Cardiovascular Imaging (EACVI) is ‘to promote excellence in clinical diagnosis, research, technical development, and education in cardiovascular imaging’. The future of ...
  • EAES Recommendations for Recovery Plan in Minimally Invasive Surgery Amid COVID-19 Pandemic 
    Arezzo, Alberto; Francis, Nader; Mintz, Yoav; Adamina, Michel; Antoniou, Stavros A; Bouvy, Nicole; Copaescu, Catalin; de Manzini, Nicolò; Di Lorenzo, Nicola; Morales-Conde, Salavador; Müller-Stich, Beat P.; Nickel, Felix; Popa, Dorin; Tait, Diana; Thomas, Cenydd; Nimmo, Susan; Paraskevis, Dimitrios; Pietrabissa, Andrea; Ignjatovic, Dejan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Background COVID-19 pandemic presented an unexpected challenge for the surgical community in general and Minimally Invasive Surgery (MIS) specialists in particular. This document aims to ...
  • Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile 
    Vedeld, Hege Marie; Grimsrud, Marit Mæhle; Andresen, Kim; Pharo, Heidi Dietrichson; von Seth, Erik; Karlsen, Tom Hemming; Honne, Hilde; Paulsen, Vemund; Färkkilä, Martti A.; Bergquist, Annika; Jeanmougin, Marine; Aabakken, Lars; Boberg, Kirsten Muri; Folseraas, Trine; Lind, Guro Elisabeth (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background and Aims Primary sclerosing cholangitis (PSC) is associated with increased risk of cholangiocarcinoma (CCA). Early and accurate CCA detection represents an unmet clinical need as the majority of patients with ...
  • Early and repeated screening detects children with persistent attention-deficit/hyperactivity disorder 
    Øvergaard, Kristin; Ørbeck, Beate; Friis, Svein; Pripp, Are Hugo; Aase, Heidi; Biele, Guido; Ingeborgrud, Christine Baalsrud; Polanczyk, Guilherme V.; Zeiner, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Preschool screening of attention-deficit/hyperactivity disorder (ADHD) has been found too inaccurate to be clinically useful. This may be due to the known instability of ADHD symptoms from preschool onwards, and ...
  • Early anti-TNF treatment in pediatric Crohn's disease. Predictors of clinical outcome in a population-based cohort of newly diagnosed patients 
    Olbjørn, Christine; Nakstad, Britt; Småstuen, Milada Cvancarova; Thiis-Evensen, Espen; Vatn, Morten H; Perminow, Gøri Margrete (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Objective: Pediatric Crohn’s disease (CD) is often debilitating, with upper gastrointestinal involvement and complications over time. Treatment with TNF blockers can induce and maintain remission. We wanted to evaluate the ...
  • Early B-Type Natriuretic Peptide Change in HFrEF Patients Treated With Sacubitril/Valsartan: A Pooled Analysis of EVALUATE-HF and PROVE-HF 
    Myhre, Peder Langeland; Prescott, Margaret F.; Murphy, Sean P.; Fang, James C.; Mitchell, Gary F.; Ward, Jonathan H.; Claggett, Brian; Desai, Akshay S.; Solomon, Scott D.; Januzzi, James L. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Objectives This study assessed changes in B-type natriuretic peptide (BNP) among patients with heart failure with reduced ejection fraction (HFrEF) treated with sacubitril/valsartan (Sac/Val) according to standard ...
  • Early cardiac-chamber-specific fingerprints in heart failure with preserved ejection fraction detected by FTIR and Raman spectroscopic techniques 
    Tombolesi, Niki; Altara, Raffaele; Silva, Gustavo Jose Justo; Tannous, Cynthia; Zouein, Fouad A.; Stensløkken, Kåre-Olav; Morresi, Assunta; Paolantoni, Marco; Booz, George W.; Cataliotti, Alessandro; Sassi, Paola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is a matter of investigation and its diagnosis remains challenging. Although the mechanisms that are responsible for the development ...
  • Early Cognitive Training Rescues Remote Spatial Memory but Reduces Cognitive Flexibility in Alzheimer's Disease Mice 
    Rai, Surya Prakash; Krohn, Markus; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background: Spatial memory dysfunction has been demonstrated in mouse models of Alzheimer’s disease (AD) which is consistent with the clinical finding that the early signature of AD includes difficulties in the formation ...
  • Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries 
    Sörensson, Peder; Ekenbäck, Christina; Lundin, Magnus; Agewall, Stefan; Bacsovics Brolin, Elin; Caidahl, Kenneth; Cederlund, Kerstin; Collste, Olov; Daniel, Maria; Jensen, Jens; Y-Hassan, Shams; Henareh, Loghman; Hofman-Bang, Claes; Lyngå, Patrik; Maret, Eva; Sarkar, Nondita; Spaak, Jonas; Winnberg, Oscar; Ugander, Martin; Tornvall, Per (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Objectives The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries ...
  • Early detection of anastomotic leakage after pancreatoduodenectomy with microdialysis catheters: an observational Study 
    Lindholm, Espen; Bergmann, Gisli Björn; Haugaa, Håkon; Labori, Knut Jørgen; Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Line, Pål-Dag; Grindheim, Guro; Kjøsen, Gisle; Pischke, Søren Erik; Tønnessen, Tor Inge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Microdialysis catheters can detect focal inflammation and ischemia, and thereby have a potential for early detection of anastomotic leakages after pancreatoduodenectomy. The aim was to investigate whether ...
  • Early detection of breast cancer based on gene-expression patterns in peripheral blood cells 
    Sharma, Praveen; Sahni, Narinder S; Tibshirani, Robert; Skaane, Per; Urdal, Petter; Berghagen, Hege; Jensen, Marianne; Kristiansen, Lena; Moen, Cecilie; Sharma, Pradeep; Zaka, Alia; Arnes, Jarle; Sauer, Torill; Akslen, Lars A; Schlichting, Ellen; Børresen-Dale, Anne-Lise; Lönneborg, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Introduction Existing methods to detect breast cancer in asymptomatic patients have limitations, and there is a need to develop more accurate and convenient methods. In this study, we investigated whether ...