Browsing Institutt for biovitenskap by Author "Utheim, Tor Paaske"

Now showing items 1-6 of 6

  • Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design 
    Pasovic, Lara; Utheim, Tor Paaske; Reppe, Sjur; Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Thiede, Bernd; Berg, Jens Petter; Messelt, Edvard Berger; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Storage of human retinal pigment epithelium (hRPE) can contribute to the advancement of cell-based RPE replacement therapies. The present study aimed to improve the quality of stored hRPE cultures by identifying storage ...
  • Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients 
    Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind; Amdal, Cecilie Delphin; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Utheim, Tor Paaske; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Patients with head and neck cancer (HNC) and patients with primary Sjögren’s syndrome (pSS) may exhibit similar symptoms of dry mouth and dry eyes, as a result of radiotherapy (RT) or a consequence of disease progression. ...
  • Sericin-induced melanogenesis in cultured retinal pigment epithelial cells is associated with elevated levels of hydrogen peroxide and inflammatory proteins 
    Khan, Ayyad Ahmad Zartasht; Jackson, Catherine; Utheim, Tor Paaske; Reppe, Sjur; Sapkota, Dipak; Olstad, Ole Kristoffer; Thiede, Bernd; Eidet, Jon Roger (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    We previously demonstrated that the silk protein sericin promotes pigmentation of retinal pigment epithelium (RPE) by activating the NF-κB pathway. Among numerous agents, NF-κB can be activated by hydrogen peroxide. In the ...
  • Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome 
    Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd; Utheim, Øygunn Aass; Palm, Øyvind; Tashbayev, Behzod; Utheim, Tor Paaske; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Ocular dryness is a characteristic feature of primary Sjögren’s syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed ...
  • The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity 
    Raheel, Tayyaba Qureshi; Sørensen, Christina; Berghuis, Paul; Jensen, Vidar; Dobszay, Marton B.; Farkas, Tamas; Dalen, Knut Tomas; Guo, Caiying; Hassel, Bjørnar; Utheim, Tor Paaske; Hvalby, Øivind C; Hafting, Torkel; Harkany, Tibor; Fyhn, Marianne; Chaudhry, Farrukh Abbas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    GABA signaling sustains fundamental brain functions, from nervous system development to the synchronization of population activity and synaptic plasticity. Despite these pivotal features, molecular determinants underscoring ...
  • Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction 
    Storås, Andrea; Fineide, Fredrik; Magnø, Morten Schjerven; Thiede, Bernd; Chen, Xiangjun; Strumke, Inga; Halvorsen, Pål; Galtung, Hilde; Jensen, Janicke Cecilie Liaaen; Utheim, Tor Paaske; Riegler, Michael Alexander (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Meibomian gland dysfunction is the most common cause of dry eye disease and leads to significantly reduced quality of life and social burdens. Because meibomian gland dysfunction results in impaired function of ...