Browsing Institutt for biovitenskap by Author "Page, Kenneth R."

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  • Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport 
    Stapleton, Nigel M.; Armstrong-Fisher, Sylvia S.; Andersen, Jan Terje; van der Schoot, C. Ellen; Porter, Charlene; Page, Kenneth R.; Falconer, Donald; de Haas, Masja; Williamson, Lorna M.; Clark, Michael R.; Vidarsson, Gestur; Armour, Kathryn L. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    We have previously generated human IgG1 antibodies that were engineered for reduced binding to the classical Fcγ receptors (FcγRI–III) and C1q, thereby eliminating their destructive effector functions (constant region ...