Browsing Institutt for biovitenskap by Author "Falnes, Pål"
Now showing items 1-13 of 13
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Engelfriet, Melanie Lianne; Malecki, Jedrzej Mieczyslaw; Forsberg, Anna F.; Falnes, Pål; Ciosk, Rafal (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)The methyltransferase-like protein 13 (METTL13) methylates the eukaryotic elongation factor 1 alpha (eEF1A) on two locations: the N-terminal amino group and lysine 55. The absence of this methylation leads to reduced protein ...
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Jakobsson, Magnus; Moen, Anders; Davidson, Ben; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)Cellular proteins are subject to frequent methylation on lysine residues, introduced by specific methyltransferases, and each lysine residue can receive up to three methyl groups. Histone methylations, which are key ...
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Malecki, Jedrzej Mieczyslaw; O'Donohue, Marie-Francoise; Kim, Yeji; Jakobsson, Magnus; Gessa, Luca; Pinto, Rita; Wu, Jie; Davydova, Erna; Moen, Anders; Olsen, Jesper V.; Thiede, Bernd; Gleizes, Pierre-Emmanuel; Leidel, Sebastian A.; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Abstract Protein methylation occurs primarily on lysine and arginine, but also on some other residues, such as histidine. METTL18 is the last uncharacterized member of a group of human methyltransferases (MTases) ...
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Falnes, Pål; Malecki, Jedrzej Mieczyslaw; Herrera Gonzalez-Molina, Maria del Carmen; Bengtsen, Mads; Davydova, Erna (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Lysine methylation is an abundant posttranslational modification, which has been most intensively studied in the context of histone proteins, where it represents an important epigenetic mark. Lysine methylation of histone ...
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Willemen, Hanneke L.D.M.; Santos Ribeiro, Patrícia Silva; Broeks, Melissa; Meijer, Nils; Versteeg, Sabine; Tiggeler, Annefien; de Boer, Teun P.; Malecki, Jedrzej Mieczyslaw; Falnes, Pål; Jans, Judith; Eijkelkamp, Niels (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Pain often persists in patients with an inflammatory disease, even when inflammation has subsided. The molecular mechanisms leading to this failure in pain resolution and the transition to chronic pain are poorly understood. ...
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Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål; Klungland, Arne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
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Jakobsson, Magnus; Malecki, Jedrzej Mieczyslaw; Nilges, Benedikt S.; Moen, Anders; Leidel, Sebastian A.; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Many cellular proteins are methylated on lysine residues and this has been most intensively studied for histone proteins. Lysine methylations on non-histone proteins are also frequent, but in most cases the functional ...
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Małecki, Jędrzej; Aileni, Vinay Kumar; Moen, Anders; Ho, Angela Y.Y.; Sørensen, Vigdis; Jakobsson, Magnus; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Lysine methylation is abundant on histone proteins, representing a dynamic regulator of chromatin state and gene activity, but is also frequent on many nonhistone proteins, including eukaryotic elongation factor 1 alpha ...
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Malecki, Jedrzej Mieczyslaw; Davydova, Erna; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Many proteins are modified by posttranslational methylation, introduced by a number of methyltransferases (MTases). Protein methylation plays important roles in modulating protein function and thus in optimizing and ...
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Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja; Maciejewska, Agnieszka M.; Krokan, Hans Einar; Klungland, Arne; Tudek, Barbara; Van den Born, Erwin; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)The ALKBH family of Fe(II) and 2-oxoglutarate dependent oxygenases comprises enzymes that display sequence homology to AlkB from E. coli, a DNA repair enzyme that uses an oxidative mechanism to dealkylate methyl and etheno ...
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Jakobsson, Magnus; Davydova, Erna; Malecki, Jedrzej Mieczyslaw; Moen, Anders; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C ...
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Aileni, Vinay Kumar; Davydova, Erna; Moen, Anders; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)A number of lysine-specific methyltransferases (KMTs) are responsible for the post-translational modification of cellular proteins on lysine residues. Most KMTs typically recognize specific motifs in unstructured, short ...
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Malecki, Jedrzej Mieczyslaw; Jakobsson, Magnus; Ho, Angela Yeuan Yen; Moen, Anders; Rustan, Arild; Falnes, Pål (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Lysine methylation is an important and much-studied posttranslational modification of nuclear and cytosolic proteins but is present also in mitochondria. However, the responsible mitochondrial lysine-specific methyltransferases ...