Browsing Institutt for biovitenskap by Author "Daba, Muluneh Bekele"

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  • A human endothelial cell-based recycling assay for screening of FcRn targeted molecules 
    Grevys, Algirdas; Nilsen, Jeannette; Sand, Kine Marita Knudsen; Daba, Muluneh Bekele; Øynebråten, Inger; Bern, Malin C.; McAdam, Martin Berner; Foss, Stian; Schlothauer, Tilman; Michaelsen, Terje Einar; Christianson, Gregory J.; Roopenian, Derry C.; Blumberg, Richard S.; Sandlie, Inger; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Furthermore, increase in half-lives of IgG and albumin-based ...