Browsing Institutt for biovitenskap by Author "Caddy, Sarah L."

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  • Complement C4 prevents viral infection through capsid inactivation 
    Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James Kennedy; O'Connell, Kevin; Clark, Jessica; Mayes, Keith; Higginson, Katie; Lode, Heidrun Elisabeth; McAdam, Martin Berner; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering ...