Browsing Institutt for biovitenskap by Author "Backe, Paul Hoff"

Now showing items 1-2 of 2

  • Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability 
    Bosshard, Matthias; Aprigliano, Rossana; Gattiker, Cristina; Palibrk, Vuk; Markkanen, Enni; Backe, Paul Hoff; Pellegrino, Stefania; Raymond, F. Lucy; Froyen, Guy; Altmeyer, Matthias; Bjørås, Magnar; Dianov, Grigory L.; van Loon, Barbara (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity ...
  • The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell?specific adapter protein 
    Andersen, Thorny Cesilie Bie; Kristiansen, Per Eugen; Huszenicza, Zsuzsa; Johansson, Maria U.; Gopalakrishnan, Ramakrishna Prabhu; Kjelstrup, Hanna; Boyken, Scott; Gjerstad, Vibeke Sundvold; Granum, Stine; Sørlie, Morten; Backe, Paul Hoff; Fulton, Bruce D; Karlsson, B.Göran; Andreotti, Amy H.; Spurkland, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    T-cell activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosine kinases, phosphatases, and adapter proteins interact to transmit signals from the T-cell receptor to the nucleus. ...