Browsing CRIStin høstingsarkiv by Title

Now showing items 18453-18472 of 31252

  • N-acetyl cysteine turns EPAC activators into potent killers of acute lymphoblastic leukemia cells 
    Richartz, Nina; Pietka, Wojciech; Yadav, Ajay; Bostad, Monica; Bhagwat, Sampada; Naderi, Soheil; Naderi, Elin Hallan; Stokke, Trond; Ruud, Ellen; Blomhoff, Heidi Kiil (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Today, the majority of patients with pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL, hereafter ALL) survive their disease, but many of the survivors suffer from life-limiting late effects of the treatment. ...
  • N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease 
    Morland, Cecilie; Nordengen, Kaja (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic glutamate receptor 3 (mGluR3). Recent data ...
  • N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug 
    Kamiński, Krzysztof; Esguerra, Camila V.; Gawel, Kinga Aurelia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    In our recent studies, we identified compound N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) as a broad-spectrum hybrid anticonvulsant which showed potent protection across the most important animal acute seizure ...
  • N-BODY SIMULATIONS FOR EXTENDED QUINTESSENCE MODELS 
    Li, Baojiu; Mota, David; Barrow, J. D. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    We introduce the N-body simulation technique to follow structure formation in linear and nonlinear regimes for the extended quintessence models (scalar-tensor theories in which the scalar field has a self-interaction ...
  • N-Heteroaryl Carbamates from Carbon Dioxide via Chemoselective Superbase−Catalysis: Substrate Scope and Mechanistic Investigation 
    Mannisto, Jere K.; Pavlovic, Ljiljana; Heikkinen, Johannes; Tiainen, Tony; Sahari, Aleksi; Maier, Norbert; Rissanen, Kari; Nieger, Martin; Hopmann, Kathrin Helen; Repo, Timo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    We report a mild superbase-catalyzed and nitrogen-selective carboxylation of N-heteroaryls, with subsequent alkylation enabling the synthesis of drug-like O-alkyl carbamates in good yields (av. 86%). Our findings suggest ...
  • N-Linked Glycosylation Supports Cross-Talk between Receptor Tyrosine Kinases and Androgen Receptor 
    Itkonen, Harri; Mills, Ian Geoffrey (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    Prostate cancer is the second most common cause of cancer-associated deaths in men and signalling via a transcription factor called androgen receptor (AR) is an important driver of the disease. Androgen treatment is known ...
  • The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening 
    Bjerregaard-Andersen, Kaare; Perdreau, Harmonie; Guldsten, Hanne; Praetorius, Jeppe; Jensen, Jan K.; Morth, Jens Preben (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
    The sodium dependent bicarbonate transporter NCBE/NBCn2 is predominantly expressed in the central nervous system (CNS). The highest protein concentrations are found in the choroid plexus. The primary function of this ...
  • N-terminal pro-B-type natriuretic peptide for prediction of ventricular arrhythmias: Data from the SMASH study 
    Sourour, Nur; Riveland, Egil Aarstad; Næsgaard, Patrycja; Kjekshus, Harald; Larsen, Alf Inge; Omland, Torbjørn; Røsjø, Helge Rørvik; Myhre, Peder Langeland (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Background Elevated N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) concentrations predict heart failure (HF) and mortality, but whether NT‐proBNP predicts ventricular arrhythmias (VA) is not clear. ...
  • N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells 
    Jin, Kang-Xuan; Zuo, Rujuan; Anastassiadis, Konstantinos; Klungland, Arne; Marr, Carsten; Filipczyk, Adam (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    N6-methyladenosine (m 6 A) deposition on messenger RNA (mRNA) controls embryonic stem cell (ESC) fate by regulating the mRNA stabilities of pluripotency and lineage transcription factors (TFs) [P. J. Batista et al., Cell ...
  • N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis 
    Quiles Jimenez, Ana Maria Teresa; Gregersen, Ida; Sousa, Mirta; Abbas, Azhar; Kong, Xiang Yi; Alseth, Ingrun; Holm, Sverre; Dahl, Tuva Børresdatter; Skagen, Karolina Ryeng; Skjelland, Mona; Aukrust, Pål; Bjørås, Magnar; Halvorsen, Bente (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, and aberrant RNA modifications have been linked to a range of human diseases. The RNA ...
  • NAD Supplement Alleviates Intestinal Barrier Injury Induced by Ethanol Via Protecting Epithelial Mitochondrial Function 
    Li, Wenli; Zhou, Yujia; Pang, Nengzhi; Hu, Qianrong; Li, Qiuyan; Sun, Yan; Ding, Yijie; Gu, Yingying; Xiao, Ying; Gao, Mengqi; Ma, Sixi; Pan, Jie; Fang, Fei; Zhang, Zhenfeng; Yang, Lili (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: The epithelial tight junction is an important intestinal barrier whose disruption can lead to the release of harmful intestinal substances into the circulation and cause damage to systemic injury. The maintenance ...
  • NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. 
    Fang, Evandro Fei; Nilsen, Hilde Loge; Rusten, Tor Erik; Khezri, Rojyar; Aman, Yahyah; Sengupta, Tanima; Hindkjær Lautrup, Sofie; Hou, Yujun; Bohr, Vilhelm A.; Jensen, Martin Borch; Yang, Beimeng; Caponio, Domenica; Demarest, Tyler G.; Figueroa, David; Morevati, Marya; Lee, Ho-Joon; Kato, Hisaya; Kassahun, Henok; Lee, Jong-Hyuk; Filippelli, Deborah; Okur, Mustafa Nazir; Mangerich, Aswin; Croteau, Deborah L.; Maezawa, Yoshiro; Lyssiotis, Costas A.; Tao, Jun; Yokoto, Koutaro; Mattson, Mark P.; Jasper, Heinrich (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Metabolic dysfunction is a primary feature of Werner syndrome (WS), a human premature aging disease caused by mutations in the gene encoding the Werner (WRN) DNA helicase. WS patients exhibit severe metabolic phenotypes, ...
  • NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs 
    Zong, Le; Tanaka-Yano, Mayuri; Park, Bongsoo; Yanai, Hagai; Turhan, Ferda T.; Croteau, Deborah L.; Tian, Jane; Fang, Evandro F.; Bohr, Vilhelm A.; Beerman, Isabel (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function ...
  • NAD+ in brain aging and neurodegenerative disorders 
    Hindkjær Lautrup, Sofie; Sinclair, David A.; Mattson, Mark P.; Fang, Evandro Fei (Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
    NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity ...
  • NaF-PET Imaging of Atherosclerosis Burden 
    Høilund-Carlsen, Poul F.; Piri, Reza; Gerke, Oke; Sturek, Michael; Werner, Thomas J.; Rootwelt-Revheim, Mona Elisabeth; Alavi, Abass (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The method of 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) of atherosclerosis was introduced 12 years ago. This approach is particularly interesting because it demonstrates ...
  • Nafamostat–interferon-α combination suppresses sars-cov-2 infection in vitro and in vivo by cooperatively targeting host tmprss2 
    Ianevski, Aleksandr; Yao, Rouan; Lysvand, Hilde; Grødeland, Gunnveig; Legrand, Nicolas; Oksenych, Valentyn; Zusinaite, Eva; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis E. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges ...
  • Nagashima-type palmoplantar keratosis in Finland caused by a SERPINB7 founder mutation 
    Hannula-Jouppi, Katariina; Harjama, Liisa; Einarsdottir, Elisabet; Elomaa, Outi; Kettunen, Kaisa; Saarela, Janna; Soronen, Minna; Bouchard, Laura; Lappalainen, Katriina; Heikkilä, Hannele; Kivirikko, Sirpa; Seppänen, Mikko R J; Kere, Juha; Ranki, Annamari (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
  • Nairobi: The Politics of the Capital 
    Jones, Peris Sean (Chapter / Bokkapittel / AcceptedVersion; Peer reviewed, 2020)
    This chapter charts some of the key characteristics of Nairobi County, particularly those of development and governance that are directly relevant for how we may imagine the capital as a city of politics. The aim is, first, ...
  • Nakalanga syndrome: clinical characteristics, potential causes, and its relationship with recently described Nodding syndrome 
    Föger, Kathrin; Gora-Stahlberg, Gina; Sejvar, James; Ovuga, Emilio; Jilek-Aall, Louise; Schmutzhard, Erich; Kaiser, Christoph; Winkler, Andrea Sylvia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Nakalanga syndrome is a condition that was described in Uganda and various other African countries decades ago. Its features include growth retardation, physical deformities, endocrine dysfunction, mental impairment, and ...
  • Naked in the eyes of the public: A phenomenological study of the lived experience of suffering from burnout while waiting for recognition to be ill 
    Engebretsen, Karin Mohn; Bjorbærkmo, Wenche Schrøder (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Although there has been a focus on problematic issues related to health care services and complaints made by patients, individuals who suffer from medically unexplained syndromes continue to report being epistemically ...