Microalbuminuria and Hypertension in the HIV-Positive Population of Oslo (MAHO Study)
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AbstractThe aims of this thesis were to study important risk factors for cardiovascular and renal diseases, i.e. microalbuminuria, hypertension and diurnal blood pressure rhythm in the HIV-infected population of Oslo.
We found that the prevalence of microalbuminuria in the HIV-infected cohort was 2–5 times higher than in the general population, while hypertension did not appear more frequently. The HIV therapy seemed to induce a certain effect on diastolic blood pressure, levels, while no such effect was demonstrated for systolic blood pressure. Furthermore, this was the first study to demonstrate an attenuated diurnal blood pressure rhythm with a reduced nocturnal blood pressure fall in the majority of hypertensive HIV-infected subjects.
The MAHO study indicates that inflammatory activity induced by HIV infection may be involved in the development of microalbuminuria, high blood pressure levels and attenuated blood pressure rhythm. The high prevalence of microalbuminuria and attenuated blood pressure rhythm in HIV-infected individuals might partially explain the increased risk for cardiovascular and renal disease.
List of Papers
I. Baekken Morten, Os Ingrid, Sandvik Leiv, Oektedalen Olav. Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population. Nephrology Dialysis Transplantation. 2008;23:3130-3137 DOI: 10.1093/ndt/gfn236
II. Baekken Morten, Os Ingrid, Sandvik Leiv, Oektedalen Olav. Hypertension in an urban HIV-positive population compared with the general population: influence of combination antiretroviral therapy. >Journal of Hypertension. 2008;26:2126-2133 DOI: 10.1097/HJH.obo13e32830ef5fb
III. Baekken Morten, Os Ingrid, Stenehjem Aud, Sandvik Leiv, Oektedalen Olav. Association between HIV infection and attenuated diurnal blood pressure rhythm in untreated hypertensive individuals. .HIV Medicine. 2009;10:44-52 DOI: 10.1111/j.1468-1293.2008.00655.x