Browsing Det odontologiske fakultet by Author "Dartt, Darlene Ann"

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  • Diagnostic Test Efficacy of Meibomian Gland Morphology and Function 
    Xiao, Jiaxin; Adil, Muhammed Yasin; Olafsson, Jonatan; Chen, Xiangjun; Utheim, Øygunn Aass; Ræder, Sten; Lagali, Neil Satish; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Meibomian gland dysfunction (MGD) is the leading cause of dry eye and proposed treatments are based on disease severity. Our purpose was to establish reliable morphologic measurements of meibomian glands for evaluating MGD ...
  • Dry Eye Disease Patients with Xerostomia Report Higher Symptom Load and Have Poorer Meibum Expressibility 
    Fostad, Ida Grunnan; Eidet, Jon Roger; Utheim, Tor Paaske; Ræder, Sten; Lagali, Neil; Messelt, Edvard Berger; Dartt, Darlene Ann (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    The purpose of the study was to investigate if xerostomia (dry mouth) is associated with symptoms and signs of dry eye disease (DED). At the Norwegian Dry Eye Clinic, patients with symptomatic DED with different etiologies ...
  • Effect of transportation on cultured limbal epithelial sheets for worldwide treatment of limbal stem cell deficiency 
    Utheim, Øygunn Aass; Lyberg, Torstein; Eidet, Jon Roger; Ræder, Sten; Sehic, Amer; Roald, Borghild; Messelt, Edvard Berger; De La Paz, María Fidéliz; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublisedVersion; Peer reviewed, 2018)
    Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present ...
  • Hot towels: The bedrock of Meibomian gland dysfunction treatment – A review 
    Magnø, Morten Schjerven; Olafsson, Jonatan; Beining, Marie Wangen; Moschowits, Emily; Lagali, Neil Satish; Wolffsohn, James S.; Craig, Jennifer P.; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Meibomian gland dysfunction (MGD) reduces quality-of-life and hinders work productivity of millions of patients, with high direct and indirect societal costs. Thickened meibum obstructs the glands and disrupts ...
  • In-office thermal systems for the treatment of dry eye disease 
    Beining, Marie Wangen; Magnø, Morten Scherven; Moschowits, Emily; Olafsson, Jonatan; Vehof, Jelle; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Dry eye disease affects millions of people worldwide, causing pain, vision disturbance, and reduced productivity. Meibomian gland dysfunction, a major cause of dry eye, is characterized by chronic glandular inflammation, ...
  • Purinergic 2X 4 (P2X4), but not P2X7, receptors increase cytosolic [Ca2+] and stimulate mucin secretion in rat conjunctival goblet cells to maintain ocular surface health 
    Fjærvoll, Haakon Kristoffer Olsen; Fjærvoll, Ketil Andreas Olsen; Yang, Menglu; Bair, Jeffrey; Utheim, Tor Paaske; Dartt, Darlene Ann (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Ionotropic purinergic receptors (P2XRs) are activated by ATP and ATP analogs. ATP can be released through ATP-permeable channels such as the pannexin hemichannels. Upon activation, the P2XRs become permeable to Ca2+, a ...
  • Simple limbal epithelial transplantation: Current status and future perspectives: Concise review 
    Jackson, Catherine; Ernø, Inger Thea Myklebust; Ringstad, Håkon; Tønseth, Kim Alexander; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Damage to limbal stem cells as a result of injury or disease can lead to limbal stem cell deficiency (LSCD). This disease is characterized by decreased vision that is often painful and may progress to blindness. Clinical ...
  • Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females 
    Fineide, Fredrik; Tashbayev, Behzod; Elgstøen, Katja B. Prestø; Sandås, Elise Mørk; Rootwelt, Helge; Hynne, Håvard; Chen, Xiangjun; Ræder, Sten; Vehof, Jelle; Dartt, Darlene Ann; Jensen, Janicke Liaaen; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Accurate diagnosis of dry eye disease (DED) is challenging, and even today there is no gold standard biomarker of DED. Hypothesis-free global metabolomic studies of tears from DED patients have great potential to discover ...
  • Tear production levels and dry eye disease severity in a large Norwegian cohort 
    Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten; Lagli, Neil; Stojanovic, Aleksandar; Dartt, Darlene Ann; Utheim, Tor Paaske (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear ...
  • Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease 
    Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen; Yazdani, Mazyar; Lagali, Neil Satish; Vitelli, Valeria; Dartt, Darlene Ann; Chen, Xiangjun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The prevalence of dry eye disease is high worldwide and poses a great burden on patients’ daily lives. Accurate diagnosis of the disease is important, and it requires application of various methods. Hyperosmolarity is ...