Browsing Det odontologiske fakultet by Author "Galtung, Hilde"

Now showing items 1-20 of 21

  • A preclinical model to investigate normal tissue damage following fractionated radiotherapy to the head and neck 
    Juvkam, Inga; Zlygosteva, Olga; Arous, Delmon; Galtung, Hilde; Malinen, Eirik; Søland, Tine Merete; Edin, Nina Frederike Jeppesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Radiotherapy (RT) of head and neck (H&N) cancer is known to cause both early- and late-occurring toxicities. To better appraise normal tissue responses and their dependence on treatment parameters ...
  • Acute normal tissue responses in a murine model following fractionated irradiation of the head and neck with protons or X-rays 
    Zlygosteva, Olga; Juvkam, Inga; Arous, Delmon; Sitarz, Mateusz; Sørensen, Brita Singers; Ankjærgaard, Christina; Andersen, Claus E.; Galtung, Hilde; Søland, Tine Merete; Edin, Nina Frederike Jeppesen; Malinen, Eirik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background The purpose of this study was to investigate acute normal tissue responses in the head and neck region following proton- or X-irradiation of a murine model. Materials and methods Female C57BL/6J mice were ...
  • Cancer cell line-specific protein profiles in extracellular vesicles identified by proteomics 
    Mazagão Guerreiro, Eduarda; Øvstebø, Reidun; Thiede, Bernd; Costea, Daniela Elena; Søland, Tine Merete; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers for diagnosis, monitoring, ...
  • Characterization of Lipids in Saliva, Tears and Minor Salivary Glands of Sjögren’s Syndrome Patients Using an HPLC/MS-Based Approach 
    Fineide, Fredrik; Chen, Xiangjun; Bjellaas, Thomas; Vitelli, Valeria; Utheim, Tor Paaske; Jensen, Janicke Liaaen; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The diagnostic work-up of primary Sjögren’s syndrome (pSS) includes quantifying saliva and tear production, evaluation of autoantibodies in serum and histopathological analysis of minor salivary glands. Thus, the potential ...
  • Cytokine Levels in Saliva Are Associated with Salivary Gland Fibrosis and Hyposalivation in Mice after Fractionated Radiotherapy of the Head and Neck 
    Zlygosteva, Olga; Juvkam, Inga; Aass, Hans Christian; Galtung, Hilde; Søland, Tine Merete; Malinen, Eirik; Edin, Nina Frederike Jeppesen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Cytokines are mediators of inflammation that could lead to fibrosis. The aim was to monitor cytokine levels in saliva and serum after locally fractionated radiotherapy of the head and neck in mice and investigate associations ...
  • Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways 
    Aqrawi, Lara A.; Chen, Xiangjun; Hynne, Håvard; Amdal, Cecilie Delphin; Reppe, Sjur; Aass, Hans Christian Dalsbotten; Rykke, Morten; Hove, Lene Hystad; Young, Alix; Herlofson, Bente Brokstad; Westgaard, Kristine Løken; Utheim, Tor Paaske; Galtung, Hilde; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Although radiotherapy is a common form of treatment for head and neck cancer, it may lead to tissue damage in the salivary and lacrimal glands, possibly affecting cytokine expression in the gland fluid of treated individuals. ...
  • Dental Erosion in Mice with Impaired Salivary Gland Function 
    Tulek, Amela; Mulic, Aida; Stenhagen, Kjersti Refsholt; Galtung, Hilde; Saeed, Muhammad; Utheim, Tor Paaske; Khuu, Cuong; Galteland, Pål; Sehic, Amer (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Objective: Salivary flow rate exerts an essential impact on the development and progression of dental erosion. In this work, the experimental dental erosion in non-obese diabetic (NOD) mice with reduced salivary flow rate ...
  • Dysbiotic salivary microbiota in dry mouth and primary Sjögren’s syndrome patients 
    Rusthen, Shermin; Kristoffersen, Anne Karin; Young, Alix; Galtung, Hilde; Petrovski, Beata; Palm, Øyvind; Enersen, Morten; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Objectives Primary Sjögren’s syndrome (pSS) is an autoimmune disease characterized by reduced lacrimal and salivary secretion. Sicca symptoms together with fatigue and musculoskeletal pain can significantly reduce the ...
  • Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography 
    Guerreiro, Eduarda; Vestad, Beate; Steffensen, Lilly Alice; Aass, Hans Christian Dalsbotten; Saeed, Muhammad; Øvstebø, Reidun; Costea, Daniela Elena; Galtung, Hilde; Søland, Tine Merete (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source of potential biomarkers for early detection of diseases such as cancer. However, ...
  • Hypo-osmotic stress drives IL-33 production in human keratinocytes - An epidermal homeostatic response 
    Pietka, Wojciech; Khnykin, Denis; Bertelsen, Vibeke; Lossius, Astrid Haaskjold; Stav-Noraas, Tor Espen; Hol, Johanna; Galtung, Hilde; Haraldsen, Guttorm; Sundnes, Olav (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Although inflammation has traditionally been considered a response to either exogenous pathogen-associated signals or endogenous signals of cell damage, other perturbations of homeostasis, generally referred to as stress, ...
  • Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains 
    Haugsten, Helene Rygvold; Kristoffersen, Anne Karin; Haug, Trude Marie; Søland, Tine Merete; Øvstebø, Reidun; Aass, Hans Christian; Enersen, Morten; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Periodontitis is an inflammatory condition caused by bacteria and represents a serious health problem worldwide as the inflammation damages the supporting tissues of the teeth and may predispose to systemic diseases. ...
  • New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth 
    Tulek, Amela; Saeed, Muhammad; Mulic, Aida; Stenhagen, Kjersti Refsholt; Utheim, Tor Paaske; Galtung, Hilde; Khuu, Cuong; Nirvani, Minou; Kristiansen, Marthe Smedmoen; Sehic, Amer (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Objective: Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are several in vitro and in situ studies focusing on the risk indicators and preventive ...
  • Non-Coding RNA in Salivary Extracellular Vesicles: A New Frontier in Sjögren's Syndrome Diagnostics? 
    Cross, Tanya; Haug, Kari Bente Foss; Brusletto, Berit; Ommundsen, Stine Kamilla; Trøseid, Anne-Marie Siebke; Aspelin, Trude; Olstad, Ole Kristoffer; Aass, Hans Christian; Galtung, Hilde; Utheim, Tor Paaske; Jensen, Janicke Liaaen; Øvstebø, Reidun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Sjögren’s syndrome is an autoimmune rheumatic disease characterized by inflammation of the salivary and lacrimal glands, often manifesting as dry mouth and dry eyes. To simplify diagnostics of primary Sjögren’s syndrome ...
  • P2 receptors as therapeutic targets in the salivary gland: From physiology to dysfunction 
    Khalafalla, Mahmoud G.; Woods, Lucas T.; Jasmer, Kimberly J.; Forti, Kevin Munoz; Camden, Jean M.; Jensen, Janicke Liaaen; Limesand, Kirsten H.; Galtung, Hilde; Weisman, Gary A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining ...
  • Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients 
    Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind; Amdal, Cecilie Delphin; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Utheim, Tor Paaske; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Patients with head and neck cancer (HNC) and patients with primary Sjögren’s syndrome (pSS) may exhibit similar symptoms of dry mouth and dry eyes, as a result of radiotherapy (RT) or a consequence of disease progression. ...
  • Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles 
    Juvkam, Inga Solgård; Zlygosteva, Olga; Sitarz, Mateusz; Thiede, Bernd; Sørensen, Brita Singers; Malinen, Eirik; Edin, Nina Frederike Jeppesen; Søland, Tine Merete; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Extracellular vesicles (EVs) are membrane-bound particles released from cells, and their cargo can alter the function of recipient cells. EVs from X-irradiated cells have been shown to play a likely role in non-targeted ...
  • Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjögren’s Syndrome 
    Hynne, Håvard; Mørk Sandås, Elise; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Utheim, Tor Paaske; Galtung, Hilde; Jensen, Janicke Liaaen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjögren’s syndrome (pSS) share many of the same symptoms despite different causes. With the ...
  • Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome 
    Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd; Utheim, Øygunn Aass; Palm, Øyvind; Tashbayev, Behzod; Utheim, Tor Paaske; Galtung, Hilde (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Ocular dryness is a characteristic feature of primary Sjögren’s syndrome (pSS). This may result in dry eye disease (DED), leading to damage of the ocular surface. Additional, non-invasive diagnostic techniques are needed ...
  • Stability and cytotoxicity of biopolymer-coated liposomes for use in the oral cavity 
    Frigaard, Julie Mari; Jensen, Janicke Liaaen; Galtung, Hilde; Hiorth, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    This study investigates the stability and cytotoxicity of biopolymer-coated liposomes for use in the oral cavity. Liposomes (3 mM and 6 mM) were prepared by the thin film method and hydrated with phosphate buffer (PB) or ...
  • The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles 
    Frigaard, Julie Mari; Jensen, Janicke Liaaen; Galtung, Hilde; Hiorth, Marianne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The unique properties and applications of nanotechnology in targeting drug delivery, cosmetics, fabrics, water treatment and food packaging have received increased focus the last two decades. The application of nanoparticles ...