Browsing Det odontologiske fakultet by Author "Dahl-Jørgensen, Knut"
Now showing items 1-8 of 8
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Holm, Laurits J.; Krogvold, Lars; Hasselby, Jane P.; Kaur, Simranjeet; Claessens, Laura A.; Russell, Mark A.; Mathews, Clayton E.; Hanssen, Kristian Folkvord; Morgan, Noel G.; Koeleman, Bobby P.C.; Roep, Bart O.; Gerling, Ivan C.; Pociot, Flemming; Dahl-Jørgensen, Knut; Buschard, Karsten (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Aims/hypothesis Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures. Here we ...
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Oikarinen, Sami; Krogvold, Lars; Edwin, Bjørn; Buanes, Trond; Korsgren, Olle; Laiho, Jutta E.; Oikarinen, Maarit; Ludvigsson, Johnny; Skog, Oskar; Anagandula, Mahesh; Frisk, Gun; Hyöty, Heikki; Dahl-Jørgensen, Knut (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Abstract Aims/hypothesis The Diabetes Virus Detection (DiViD) study is the first study to laparoscopically collect pancreatic tissue and purified pancreatic islets together with duodenal mucosa, serum, ...
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Krogvold, Lars; Leete, Pia; Mynarek, Ida Maria; Russell, Mark A.; Gerling, Ivan C.; Lenchik, Nataliya I.; Mathews, Clayton; Richardson, Sarah J.; Morgan, Noel G.; Dahl-Jørgensen, Knut (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Aims/hypothesis: The Diabetes Virus Detection (DiViD) study has suggested the presence of low-grade enteroviral infection in pancreatic tissue collected from six of six live adult patients newly diagnosed with type 1 ...
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Reddy, Shiva; Krogvold, Lars; Martin, Charlton; Holland, Rebecca; Choi, Jaimin; Woo, Hannah; Wu, Fiona; Dahl-Jørgensen, Knut (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)Aims/hypothesis Although IL-1β is considered a key mediator of beta cell destruction, its cellular expression in islets during early type 1 diabetes remains unclear. We compared its expression in rare pancreatic biopsies ...
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Rodriguez-Calvo, Teresa; Zapardiel-Gonzalo, Jose; Amirian, Natalie; Castillo, Ericka; Lajevardi, Yasaman; Krogvold, Lars; Dahl-Jørgensen, Knut; Von Herrath, Matthias G. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)Type 1 diabetes is characterized by the loss of insulin production caused by β-cell dysfunction and/or destruction. The hypothesis that β-cell loss occurs early during the prediabetic phase has recently been challenged. ...
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Krogvold, Lars; Genoni, Angelo; Puggioni, Anna; Campani, Daniela; Richardson, Sarah J.; Flaxman, Christine S.; Edwin, Bjørn von Gohren; Buanes, Trond; Dahl-Jørgensen, Knut; Toniolo, Antonio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Abstract Aims/hypothesis Enterovirus (EV) infection of pancreatic islet cells is one possible factor contributing to type 1 diabetes development. We have reported the presence of EV genome by PCR and ...
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Välikangas, Tommi; Lietzén, Niina; Jaakkola, Maria K.; Krogvold, Lars; Eike, Morten Christoph; Kallionpää, Henna; Tuomela, Soile; Mathews, Clayton; Gerling, Ivan C.; Oikarinen, Sami; Hyöty, Heikki; Dahl-Jørgensen, Knut; Elo, Laura L.; Lahesmaa, Riitta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Although type 1 diabetes (T1D) is primarily a disease of the pancreatic beta-cells, understanding of the disease-associated alterations in the whole pancreas could be important for the improved treatment or the prevention ...
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Pancreatic alpha-cells contribute together with beta-cells to CXCL10 expression in type 1 diabetes Nigi, Laura; Brusco, Noemi; Grieco, Giuseppina E.; Licata, Giada; Krogvold, Lars; Marselli, Lorella; Gysemans, Conny; Overbergh, Lut; Marchetti, Piero; Mathieu, Chantal; Dahl-Jørgensen, Knut; Sebastiani, Guido; Dotta, Francesco (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)C-X-C Motif Chemokine Ligand 10 (CXCL10) is a pro-inflammatory chemokine specifically recognized by the ligand receptor CXCR3 which is mostly expressed in T-lymphocytes. Although CXCL10 expression and secretion have been ...