Browsing Institutt for medisinske basalfag by Title

Now showing items 1448-1467 of 3151

  • “I have to do things differently now, but I make it work”—young childhood cancer survivors’ experiences of self-management in everyday living 
    Larsen, Marie Hamilton; Larsen, Elna Hamilton; Ruud, Ellen; Mellblom, Anneli; Helland, Sunniva; Lie, Hanne Cathrine (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Purpose Living with late effects can affect young childhood cancer survivors’ (CCSs) self-management (SM) abilities. In this study, we explored different approaches to SM of everyday life by ...
  • Identification and characterisation of novel protein kinase A Cb splice variants expressed in NT2-N cells differentiated by retinoic acid 
    Larsen, Anja Camilla Vogeler (Master thesis / Hovedoppgave, 2005)
    Protein kinase A (PKA) is a holoenzyme consisting of a regulatory (R) subunit dimer and two catalytic (C) subunits. Humans contain at least four genes that express four isoforms of the C subunits, designated Cá, Câ, Cã and ...
  • Identification and characterization of a novel glutaminase inhibitor 
    Cederkvist, Fritjof Henning; Kolan, Shrikant; Wik, Jonas Aakre; Sener, Zeynep; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    In humans, there are two forms of glutaminase (GLS), designated GLS1 and GLS2. These enzymes catalyse the conversion of glutamine to glutamate. GLS1 exists as two isozymes: kidney glutaminase (KGA) and glutaminase C (GAC). ...
  • Identification and Characterization of Novel Mutations in the Human Gene Encoding the Catalytic Subunit Calpha of Protein Kinase A (PKA) 
    Søberg, Kristoffer; Larsen, Anja C V; Diskar, Mandy; Backe, Paul Hoff; Bjørås, Magnar; Jahnsen, Tore; Lærdahl, Jon Kristen; Rognes, Torbjørn; Herberg, Friedrich W.; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a ...
  • Identification of a novel compound that simultaneously impairs the ubiquitin-proteasome system and autophagy 
    Giovannucci, Tatiana A.; Salomons, Florian A.; Stoy, Henriette; Herzog, Laura K.; Xu, Shanshan; Qian, Weixing; Merino, Lara G.; Gierisch, Maria E.; Haraldsson, Martin; Lystad, Alf H.; Uvell, Hanna; Simonsen, Anne; Gustavsson, Anna-Lena; Vallin, Michaela; Dantuma, Nico P. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of ...
  • Identification of a Phage Display-Derived Peptide Interacting with the N-Terminal Region of Factor VII Activating Protease (FSAP) Enables Characterization of Zymogen Activation 
    Berge-Seidl, Sebastian; Nielsen, Nis Valentin; Alfonso, Armando A Rodriguez; Etscheid, Michael; Kandanur, Sai Priya Sarma; Haug, Bengt Erik; Stensland, Maria; Thiede, Bernd; Karacan, M; Preising, N; Wiese, S; Standker, L; Declerck, Paul J.; Løset, Geir Åge; Kanse, Sandip (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Factor VII Activating protease (FSAP) has a protective effect in diverse disease conditions as inferred from studies in FSAP–/– mice and humans deficient in FSAP activity due to single-nucleotide polymorphism. The zymogen ...
  • Identification of gluten T cell epitopes driving celiac disease 
    Chlubnova, Marketa; Christophersen, Asbjørn Otto; Sandve, Geir Kjetil Ferkingstad; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Dahal-Koirala, Shiva; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    CD4+ T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion ...
  • Identification of Human NK17/NK1 Cells 
    Pandya, Abhilash D.; Al-Jaderi, Zaidoon; Høglund, Rune A.; Holmøy, Trygve; Harbo, Hanne F.; Norgauer, Johannes; Maghazachi, Azzam A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Natural killer (NK) cells have both cytolytic and immunoregulatory functions. We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK ...
  • Identification of multiplicatively acting modulatory mutational signatures in cancer 
    Kičiatovas, Dovydas; Guo, Qingli; Kailas, Miika; Pesonen, Henri; Corander, Jukka; Kaski, Samuel; Pitkänen, Esa; Mustonen, Ville (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background A deep understanding of carcinogenesis at the DNA level underpins many advances in cancer prevention and treatment. Mutational signatures provide a breakthrough conceptualisation, as well as an ...
  • Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines 
    Mygland, Line; Mahmuda, Shoshy; Strand, Martin Frank; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Lund, Kaja; Solberg, Nina; Lycke, Eric Maximilian; Thorvaldsen, Tor Espen; Espada, Sandra; Misaghian, Dorna; Page, Christian Magnus; Agafonov, Oleg; Nygård, Ståle; Chi, Nai-Wen; Lin, Eva; Tan, Jenille; Yu, Yihong; Costa, Mike; Krauss, Stefan; Waaler, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Small-molecule tankyrase 1 and tankyrase 2 (TNKS1/2) inhibitors are effective antitumor agents in selected tumor cell lines and mouse models. Here, we characterized the response signatures and the in-depth mechanisms for ...
  • Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis 
    Kolan, Shrikant; Li, Gaoyang; Grimolizzi, Franco; Sexton, Joe; Goll, Guro Løvik; Kvien, Tore Kristian; Sundlisæter, Nina Beate Paulshus; Zucknick, Manuela; Lillegraven, Siri; Haavardsholm, Espen; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Methotrexate is one of the cornerstones of rheumatoid arthritis (RA) therapy. Genetic factors or single nucleotide polymorphisms (SNPs) are responsible for 15%–30% of the variation in drug response. Identification of ...
  • Identification of the lipid droplet-associated protein adipophilin as a novel liver x receptor target gene 
    Mathisen, Roger (Master thesis / Hovedoppgave, 2004)
    Liver X receptors are nuclear receptors that regulate cholesterol and fatty acid metabolism. Despite the critical role fatty acids play in energy metabolism, the information is scarce regarding molecular processes governing ...
  • Identification of transcription factors and response elements driving expression of Plin5 
    Hjørnevik, Tone Lise Aarnes (Master thesis / Masteroppgave, 2012)
    Obesity is a major health problem in the world today, as it results in several metabolic changes leading to elevated risk of various severe conditions such as cancer, diabetes mellitus, coronary heart disease and stroke. ...
  • Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cβ2 
    Funderud, Ane; Henanger, Heidi H; Hafte, Tilahun T; Amieux, Paul S; Ørstavik, Sigurd; Skålhegg, Bjørn S (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)
    Background Two main genes encoding the catalytic subunits Cα and Cβ of cyclic AMP dependent protein kinase (PKA) have been identified in all vertebrates examined. The murine, bovine and human Cβ genes encode ...
  • Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes 
    Andreassen, Ole Andreas; McEvoy, Linda K.; Thompson, Wesley K.; Wang, Yunpeng; Reppe, Sjur; Schork, Andrew J.; Zuber, Verena; Barrett-Connor, Elizabeth; Gautvik, Kaare M; Aukrust, Pål; Karlsen, Tom Hemming; Djurovic, Srdjan; Desikan, Rahul S.; Dale, Anders (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)
    Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few ...
  • Identifying dietary patterns across age, educational level and physical activity level in a cross-sectional study: the Tromsø Study 2015 - 2016 
    Moe, Åse M.; Sørbye, Sigrunn H.; Hopstock, Laila A.; Carlsen, Monica H.; Løvsletten, Ola; Ytterstad, Elinor (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background A healthy diet can decrease the risk of several lifestyle diseases. From studying the health effects of single foods, research now focuses on examining complete diets and dietary patterns ...
  • Identifying elemental genomic track types and representing them uniformly 
    Gundersen, Sveinung; Kalaš, Matúš; Abul, Osman; Frigessi, Arnoldo; Hovig, Eivind; Sandve, Geir K (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background With the recent advances and availability of various high-throughput sequencing technologies, data on many molecular aspects, such as gene regulation, chromatin dynamics, and the three-dimensional ...
  • Identifying the views of adolescents in five european countries on the drivers of obesity using group model building 
    Savona, Natalie; Macauley, Talia; Aguiar Rodriguez, Anaely; Banik, Anna; Boberska, Monika; Brock, Jessica; Brown, Andrew; Hayward, Joshua; Holbæk, Helene; Rito, Ana Isabel; Mendes, Sofia; Vaaheim, Fredrik; Van Houten, Marloes; Veltkamp, Gerlieke; Allender, Steven; Rutter, Harry; Knai, Cécile (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Background To make effective progress towards a global reduction in obesity prevalence, there needs to be a focus on broader structural factors, beyond individual-level drivers ...
  • IK1 channels do not contribute to the slow afterhyperpolarization in pyramidal neurons 
    Wang, Kang; Mateos-Aparicio, Pedro; Hönigsperger, Christoph; Raghuram, Vijeta; Wu, Wendy W; Ridder, Margreet C; Sah, Pankaj; Maylie, Jim; Storm, Johan F; Adelman, John P (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    In pyramidal neurons such as hippocampal area CA1 and basolateral amygdala, a slow afterhyperpolarization (sAHP) follows a burst of action potentials, which is a powerful regulator of neuronal excitability. The sAHP amplitude ...
  • IL-9 ved aterosklerotisk hjerte- og karsykom 
    Gregersen, Ida (Master thesis / Masteroppgave, 2011)
    Kardiovaskulær sykdom forårsaket av aterosklerose er den hyppigste dødsårsaken i vestlige land, samtidig som forekomst og dødelighet også øker i resten av verden. Tross en nedgang de siste 40 årene er hjerte- og karsykdom, ...