Browsing Institutt for medisinske basalfag by Title
Now showing items 1-20 of 3153
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Flutemetamol (18F-Flut) is an [18F]-labelled amyloid PET tracer with increasing availability. The main objectives of this study were to investigate 1) cerebrospinal fluid (CSF) Aβ 1-42 (Aβ42) concentrations associated with ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Abstract 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-adenosine diphosphate (ADP)-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, ...
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2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Background and aims A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...
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(Journal article / Tidsskriftartikkel / PublishedVersion, 2017)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp−/− mice exhibit increased sensitivity ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes via the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)In vitro derived simplified 3D representations of human organs or organ functionalities are predicted to play a major role in disease modeling, drug development, and personalized medicine, as they complement traditional ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Microfluidics have been used for several decades to conduct a wide range of research in chemistry and the life sciences. The reduced dimensions of these devices give them advantages over classical analysis techniques such ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Background Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Objective To systematically evaluate health literacy (HL) interventions in chronic conditions by exploring theoretical perspectives, intervention content and effectiveness. Method We searched MEDLINE, Cochrane, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Abstract The COVID-19 pandemic has become a global health crisis, inflicting substantial morbidity and mortality worldwide. A diverse range of symptoms, including fever, cough, dyspnea, and fatigue, characterizes COVID-19. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)Background Age-related alterations in metabolism and excretion of medications increase the risk of adverse drug events in the elderly. Inappropriate polypharmacy and prescription practice entails increased ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)This work demonstrates how a multi-electrode array (MEA) dedicated to four-electrode bioimpedance measurements can be implemented on a complementary metal–oxide–semiconductor (CMOS) chip. As a proof of concept, an 8 × 8 ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Kidney transplantation (KT) is considered the best treatment for end-stage kidney disease (ESKD). In the increasing elderly ESKD population, KT should be reserved for carefully selected candidates who are expected to ...