Browsing Institutt for molekylær biovitenskap by Author "Zhao, Y"

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  • Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential 
    Stapleton, NM; Andersen, Jan Terje; Stemerding, AM; Bjarnarson, SP; Verheul, RC; Gerritsen, J.; Zhao, Y; Kleijer, M; Sandlie, Inger; de Haas, Masja; Jonsdottir, I; van der Schoot, CE; Vidarsson, G. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that IgG3 binds to IgG-salvage receptor (FcRn), but that FcRn-mediated transport and ...