Browsing Institutt for molekylær biovitenskap by Author "Myklebost, Ola"

Now showing items 1-12 of 12

  • Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study 
    Wang, Junbai; Delabie, Jan; Christian Aasheim, Hans; Smeland, Erlend; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2002)
    Background A method to evaluate and analyze the massive data generated by series of microarray experiments is of utmost importance to reveal the hidden patterns of gene expression. Because of the complexity ...
  • Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential 
    Francis, Princy; Maria Namløs, Heidi; Müller, Christoph; Edén, Patrik; Fernebro, Josefin; Berner, Jeanne-Marie; Bjerkehagen, Bodil; Åkerman, Måns; Bendahl, Pär-Ola; Isinger, Anna; Rydholm, Anders; Myklebost, Ola; Nilbert, Mef (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Soft tissue sarcoma (STS) diagnosis is challenging because of a multitude of histopathological subtypes, different genetic characteristics, and frequent intratumoral pleomorphism. One-third of ...
  • Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance 
    Nygaard, Vigdis; Løland, Anders; Holden, Marit; Langaas, Mette; Rue, Håvard; Liu, Fang; Myklebost, Ola; Fodstad, Øystein; Hovig, Eivind; Smith-Sørensen, Birgitte (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2003)
    Background A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically ...
  • Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours 
    Kresse, Stine H; Szuhai, Karoly; Barragan-Polania, Ana H; Rydbeck, Halfdan; Cleton-Jansen, Anne-Marie; Myklebost, Ola; Meza-Zepeda, Leonardo A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array ...
  • Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses 
    Kleivi, Kristine; Lind, Guro E; Diep, Chieu B; Meling, Gunn I; Brandal, Lin T; Nesland, Jahn M; Myklebost, Ola; Rognum, Torleiv O; Giercksky, Karl-Erik; Skotheim, Rolf I; Lothe, Ragnhild A (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2007)
    Background Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the ...
  • GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data 
    Lyng, Heidi; Lando, Malin; Brøvig, Runar S; Svendsrud, Debbie H; Johansen, Morten; Galteland, Eivind; Brustugun, Odd T; Meza-Zepeda, Leonardo A; Myklebost, Ola; Kristensen, Gunnar B; Hovig, Eivind; Stokke, Trond (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)
    Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers ...
  • Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells 
    Henriksen, Jørn; Stabell, Marianne; Meza-Zepeda, Leonardo A; Lauvrak, Silje A; Kassem, Moustapha; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)
    Background The HMGA2 gene, coding for an architectural transcription factor involved in mesenchymal embryogenesis, is frequently deranged by translocation and/or amplification in mesenchymal tumours, generally ...
  • Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential 
    Stratford, Eva W; Castro, Russell; Wennerstrøm, Anna; Holm, Ruth; Munthe, Else; Lauvrak, Silje; Bjerkehagen, Bodil; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Aldehyde dehydrogenase (ALDH) has recently been shown to be a marker of cancer stem-like cells (CSCs) across tumour types. The primary goals of this study were to investigate whether ALDH is expressed in liposarcomas, and ...
  • M-CGH: Analysing microarray-based CGH experiments 
    Wang, Junbai; Meza-Zepeda, Leonardo A; Kresse, Stine H; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2004)
    Background Microarray-based comparative genomic hybridisation (array CGH) is a technique by which variation in relative copy numbers between two genomes can be analysed by competitive hybridisation to DNA ...
  • Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH 
    Kresse, Stine H; Berner, Jeanne-Marie; Meza-Zepeda, Leonardo A; Gregory, Simon G; Kuo, Wen-Lin; Gray, Joe W; Forus, Anne; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2005)
    Background Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least ...
  • MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines 
    Ohnstad, Hege O; Paulsen, Erik B; Noordhuis, Paul; Berg, Marianne; Lothe, Ragnhild A; Vassilev, Lyubomir T; Myklebost, Ola (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Frequent failure and severe side effects of current sarcoma therapy warrants new therapeutic approaches. The small-molecule MDM2 antagonist Nutlin-3a activates the p53 pathway and efficiently ...
  • mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts 
    Kuijjer, Marieke L; Namløs, Heidi M; Hauben, Esther I; Machado, Isidro; Kresse, Stine H; Serra, Massimo; Llombart-Bosch, Antonio; Hogendoorn, Pancras C; Meza-Zepeda, Leonardo A; Myklebost, Ola; Cleton-Jansen, Anne-Marie (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)
    Background Conventional high-grade osteosarcoma is a primary malignant bone tumor, which is most prevalent in adolescence. Survival rates of osteosarcoma patients have not improved significantly in the last ...