dc.date.accessioned | 2022-01-27T20:22:36Z | |
dc.date.available | 2022-01-27T20:22:36Z | |
dc.date.created | 2021-08-27T08:36:58Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Li, Gaoyang Kolan, Shrikant Guo, Shuai Marciniak, Katarzyna Kolan, Pratibha Shrikant Malachin, Giulia Grimolizzi, Franco Haraldsen, Guttorm Skålhegg, Bjørn Steen . Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice. Frontiers in Immunology. 2021, 12, 1-15 | |
dc.identifier.uri | http://hdl.handle.net/10852/90227 | |
dc.description.abstract | Delayed-type hypersensitivity arthritis (DTHA) is a recently established experimental model of rheumatoid arthritis (RA) in mice with pharmacological values. Despite an indispensable role of CD4+ T cells in inducing DTHA, a potential role for CD4+ T cell subsets is lacking. Here we have quantified CD4+ subsets during DTHA development and found that levels of activated, pro-inflammatory Th1, Th17, and memory CD4+ T cells in draining lymph nodes were increased with differential dynamic patterns after DTHA induction. Moreover, according to B-cell depletion experiments, it has been suggested that this cell type is not involved in DTHA. We show that DTHA is associated with increased levels of B cells in draining lymph nodes accompanied by increased levels of circulating IgG. Finally, using the anti-rheumatoid agents, methotrexate (MTX) and the anti-inflammatory drug dexamethasone (DEX), we show that MTX and DEX differentially suppressed DTHA-induced paw swelling and inflammation. The effects of MTX and DEX coincided with differential regulation of levels of Th1, Th17, and memory T cells as well as B cells. Our results implicate Th1, Th17, and memory T cells, together with activated B cells, to be involved and required for DTHA-induced paw swelling and inflammation. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice | |
dc.type | Journal article | |
dc.creator.author | Li, Gaoyang | |
dc.creator.author | Kolan, Shrikant | |
dc.creator.author | Guo, Shuai | |
dc.creator.author | Marciniak, Katarzyna | |
dc.creator.author | Kolan, Pratibha Shrikant | |
dc.creator.author | Malachin, Giulia | |
dc.creator.author | Grimolizzi, Franco | |
dc.creator.author | Haraldsen, Guttorm | |
dc.creator.author | Skålhegg, Bjørn Steen | |
cristin.unitcode | 185,51,13,0 | |
cristin.unitname | Avdeling for ernæringsvitenskap | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1929121 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Immunology&rft.volume=12&rft.spage=1&rft.date=2021 | |
dc.identifier.jtitle | Frontiers in Immunology | |
dc.identifier.volume | 12 | |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2021.689057 | |
dc.identifier.urn | URN:NBN:no-92805 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1664-3224 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/90227/1/fimmu-12-689057%2B%25281%2529.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 68957 | |