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dc.date.accessioned2021-11-01T17:00:42Z
dc.date.available2021-11-01T17:00:42Z
dc.date.created2021-10-20T12:11:52Z
dc.date.issued2021
dc.identifier.citationFalk, Ragnhild Sørum Mariampillai, Julian Eek Prestgaard, Erik Edvard Heir, Trond Bodegard, Johan Robsahm, Trude Eid Grundvold, Irene Skretteberg, Per Torger Engeseth, Kristian Bjørnholt, Jørgen Stavem, Knut Liestøl, Knut Sandvik, Leiv Thaulow, Erik Erikssen, Gunnar Kjeldsen, Sverre Gjesdal, Knut Erikssen, Jan Emil . The Oslo Ischaemia Study: cohort profile. BMJ Open. 2021
dc.identifier.urihttp://hdl.handle.net/10852/89097
dc.description.abstractPurpose The Oslo Ischaemia Study was designed to investigate the prevalence and predictors of silent coronary disease in Norwegian middle-aged men, specifically validating exercise electrocardiography (ECG) findings compared with angiography. The study has been important in investigating long-term predictors of cardiovascular morbidity and mortality, as well as investigating a broad spectrum of epidemiological and public health perspectives. Participants In 1972–1975, 2014 healthy men, 40–59 years old, were enrolled in the study. Comprehensive clinical examination included an ECG-monitored exercise test at baseline and follow-ups. The cohort has been re-examined four times during 20 years. Linkage to health records and national health registries has ensured complete endpoint registration of morbidity until the end of 2006, and cancer and mortality until the end of 2017. Findings to date The early study results provided new evidence, as many participants with a positive exercise ECG, but no chest pain (‘silent ischaemia’), did not have significant coronary artery stenosis after all. Still, they were over-represented with coronary disease after years of follow-up. Furthermore, participants with the highest physical fitness had lower risk of cardiovascular disease, and the magnitude of blood pressure responses to moderate exercise was shown to influence the risk of cardiovascular disease and mortality. With time, follow-up data allowed the scope of research to expand into other fields of medicine, with the aim of investigating predictors and the importance of lifestyle and risk factors. Future plans Recently, the Oslo Ischaemia Study has been found worthy, as the first scientific study, to be preserved by The National Archives of Norway. All the study material will be digitised, free to use and accessible for all. In 2030, the Oslo Ischaemia Study will be linked to the Norwegian Cause of Death Registry to obtain complete follow-up to death. Thus, a broad spectrum of additional opportunities opens.
dc.languageEN
dc.publisherBMJ Publishing Group
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleThe Oslo Ischaemia Study: cohort profile
dc.typeJournal article
dc.creator.authorFalk, Ragnhild Sørum
dc.creator.authorMariampillai, Julian Eek
dc.creator.authorPrestgaard, Erik Edvard
dc.creator.authorHeir, Trond
dc.creator.authorBodegard, Johan
dc.creator.authorRobsahm, Trude Eid
dc.creator.authorGrundvold, Irene
dc.creator.authorSkretteberg, Per Torger
dc.creator.authorEngeseth, Kristian
dc.creator.authorBjørnholt, Jørgen
dc.creator.authorStavem, Knut
dc.creator.authorLiestøl, Knut
dc.creator.authorSandvik, Leiv
dc.creator.authorThaulow, Erik
dc.creator.authorErikssen, Gunnar
dc.creator.authorKjeldsen, Sverre
dc.creator.authorGjesdal, Knut
dc.creator.authorErikssen, Jan Emil
cristin.unitcode185,51,15,0
cristin.unitnameAvdeling for biostatistikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1947262
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ Open&rft.volume=&rft.spage=&rft.date=2021
dc.identifier.jtitleBMJ Open
dc.identifier.volume11
dc.identifier.issue10
dc.identifier.doihttps://doi.org/10.1136/bmjopen-2021-049111
dc.identifier.urnURN:NBN:no-91711
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2044-6055
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/89097/1/Falk%2Bet%2Bal.pdf
dc.type.versionPublishedVersion
cristin.articleide049111


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