dc.contributor.author | Mai, The T | |
dc.contributor.author | Turner, Paul | |
dc.contributor.author | Corander, Jukka | |
dc.date.accessioned | 2021-03-30T05:02:05Z | |
dc.date.available | 2021-03-30T05:02:05Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | BMC Bioinformatics. 2021 Mar 27;22(1):164 | |
dc.identifier.uri | http://hdl.handle.net/10852/85052 | |
dc.description.abstract | Background
Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences. Existing methods for estimating heritability are most often based on random-effect models, typically for computational reasons. The alternative of using a fixed-effect model has received much more limited attention in the literature.
Results
In this paper, we propose a generic strategy for heritability inference, termed as “boosting heritability”, by combining the advantageous features of different recent methods to produce an estimate of the heritability with a high-dimensional linear model. Boosting heritability uses in particular a multiple sample splitting strategy which leads in general to a stable and accurate estimate. We use both simulated data and real antibiotic resistance data from a major human pathogen, Sptreptococcus pneumoniae, to demonstrate the attractive features of our inference strategy.
Conclusions
Boosting is shown to offer a reliable and practically useful tool for inference about heritability. | |
dc.language.iso | eng | |
dc.rights | The Author(s) | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Boosting heritability: estimating the genetic component of phenotypic variation with multiple sample splitting | |
dc.type | Journal article | |
dc.date.updated | 2021-03-30T05:02:08Z | |
dc.creator.author | Mai, The T | |
dc.creator.author | Turner, Paul | |
dc.creator.author | Corander, Jukka | |
dc.identifier.cristin | 1908220 | |
dc.identifier.doi | https://doi.org/10.1186/s12859-021-04079-7 | |
dc.identifier.urn | URN:NBN:no-87721 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/85052/1/12859_2021_Article_4079.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | 164 | |