Intergenerational association between birth weight and cardiovascular disease; a population-based study of offspring, their parents, aunts and uncles
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AbstractIn this population-based study, we linked different Norwegian health registries (the Medical Birth Registry, the Cause of Death Registry, the Education Registry) and health surveys (County study, Age 40 Program, CONOR) to study the association between offspring birthweight (BW) and CVD risk in parents, aunts/uncles and partners of aunts/uncles. Offspring BW was inversely associated with CVD mortality among parents and among aunts/uncles, with stronger association in mothers compared to fathers and aunts/uncles. Established CVD risk factors contributed substantially to the associations among all relationships, and that smoking was the most influential risk factor. Moreover, low offspring BW was associated with an unfavorable CVD risk factor profile in all family members. For smoking and higher education, the associations were also reported among partners of aunts/uncles. In conclusion, both shared genetic and environmental factors play a role in the transgenerational associations between BW and CVD. Assortative mating and genetic nurturing can also contribute to these associations. Our findings may contribute to early identification of individuals at increased risk of CVD and to develop an effective prevention.
List of papers
|Paper I: Offspring birth weight and cardiovascular mortality among parents: the role of cardiovascular risk factors. Fareeha Shaikh F, Marte Karoline Kjøllesdal MK, Øyvind Naess. Journal of Developmental Origins of Health and Disease 2018; doi: 10.1017/S2040174418000065. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1017/S2040174418000065|
|Paper II: Birthweight in offspring and cardiovascular mortality in their parents, aunts and uncles: a family-based cohort study of 1.35 million births. Fareeha Shaikh, Marte Karoline Kjøllesdal, David Carslake, Camilla Stoltenberg, George Davey Smith, Øyvind Næss. International Journal of Epidemiology, 2019; doi: 10.1093/ije/dyz156. The article is included in the thesis. Also available at: https://doi.org/10.1093/ije/dyz156|
|Paper III: Cardiovascular risk factors in extended family members and birth weight in offspring. Fareeha Shaikh, Marte Karoline Kjøllesdal, David Carslake, Magne Thoresen, Øyvind Næss. (submitted) To be published. The paper is not available in DUO awaiting publishing.|