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Now showing items 1-57 of 57
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Epilepsy is clinically heterogeneous, and neurological or psychiatric comorbidities are frequently observed in patients. It has not been tested whether common risk variants for generalized or focal epilepsy are enriched ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Experience-dependent modulation of the visual evoked potential (VEP) is a promising proxy measure of synaptic plasticity in the cerebral cortex. However, existing studies are limited by small to moderate sample sizes as ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The restructuring and optimization of the cerebral cortex from early childhood and through adolescence is an essential feature of human brain development, underlying immense cognitive improvements. Beyond established ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background Mental disorders and individual characteristics such as intelligence and personality are complex traits sharing a largely unknown neuronal basis. Their genetic architectures are highly polygenic and overlapping, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting‐state ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The thickness of the cerebral cortical sheet and its surface area are highly heritable traits thought to have largely distinct polygenic architectures. Despite large-scale efforts, the majority of their genetic determinants ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Bipolar disorder (BD) is a severe manic-depressive illness. Patients with BD have been shown to have gray matter (GM) deficits in prefrontal, frontal, parietal, and temporal regions; however, the relationship between ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Human brain development involves spatially and temporally heterogeneous changes, detectable across a wide range of magnetic resonance imaging (MRI) measures. Investigating the interplay between multimodal MRI and polygenic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
While a growing literature links cardiac autonomic dysregulation to a variety of psychiatric disorders, the relationship between cardiac autonomic functioning and specific symptoms in schizophrenia (SZ) and bipolar disorder ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders. However, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Multiple sclerosis (MS) is an inflammatory disorder of the central nervous system. By combining longitudinal MRI-based brain morphometry and brain age estimation using machine learning, we tested the hypothesis that MS ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Restriction spectrum imaging (RSI) is a recently introduced magnetic resonance imaging diffusion technique. The utility of RSI in multiple sclerosis (MS) is unknown. To investigate the association between RSI-derived ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Oxytocin is a neuropeptide involved in animal and human reproductive and social behavior. Three oxytocin signaling genes have been frequently implicated in human social behavior: OXT (structural gene for oxytocin), OXTR ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2019)
Aims/hypothesis
MODY can be wrongly diagnosed as type 1 diabetes in children. We aimed to find the prevalence of MODY in a nationwide population-based registry of childhood diabetes.
Methods
Using next-generation ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
The brain is the most complex of human organs, and the pathophysiology underlying abnormal brain function in psychiatric disorders is largely unknown. Despite the rapid development of diagnostic tools and treatments in ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Background
Accumulating evidence supports cerebellar involvement in mental disorders, such as schizophrenia, bipolar disorder, depression, anxiety disorders, and attention-deficit/hyperactivity disorder. However, little ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
Reduced telomere length (TL) and structural brain abnormalities have been reported in patients with schizophrenia (SZ) and bipolar disorder (BD). Childhood traumatic events are more frequent in SZ and BD than in healthy ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
Objectives
Previous studies found evidence for thinner frontotemporal cortices in bipolar disorder (BD), yet whether this represents a stable disease trait or an effect of mood episodes remains unknown. Here, we assessed ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective biological markers, such as those based on brain imaging, could aid in clinical management of BD. Machine learning (ML) brings ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Visual evoked potential (VEP) plasticity is a promising assay for noninvasive examination of long-term potentiation (LTP)-like synaptic processes in the cerebral cortex. We conducted longitudinal and cross-sectional ...
(Journal article / Tidsskriftartikkel / SubmittedVersion, 2018)
Background: Cerebral myeloarchitecture shows substantial development across childhood and adolescence, and aberrations in these trajectories are relevant for a range of mental disorders. Differential myelination between ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
Study Objectives
To assess white matter involvement in H1N1-vaccinated hypocretin deficient patients with narcolepsy type 1 (NT1) compared with first-degree relatives (a potential risk group) and healthy controls.
Me ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
Human adolescence is a period of rapid changes in cognition and goal-directed behavior, and it constitutes a major transitional phase towards adulthood. One of the mechanisms suggested to underlie the protracted maturation ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
Objective: To investigate longitudinal changes in cortical and subcortical volumes in patients with mild traumatic brain injury (MTBI) and to evaluate whether such changes were associated with self-reported post-concussive ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
There is growing interest in using intranasal oxytocin (OT) to treat social dysfunction in schizophrenia and bipolar disorders (i.e., psychotic disorders). While OT treatment results have been mixed, emerging evidence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
As findings on the neuropathological and behavioral components of Alzheimer’s disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Objective: Accurate outcome prediction models for patients with mild traumatic brain injury (MTBI) are key for prognostic assessment and clinical decision-making. Using multivariate machine learning, we tested the unique ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal injury (DAI) may be the primary pathologic feature of MTBI but is normally ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
Heart rate variability (HRV) has become an increasingly popular index of cardiac autonomic control in the biobehavioral sciences due to its relationship with mental illness and cognitive traits. However, the intraindividual ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
The brain underpinnings of schizophrenia and bipolar disorders are multidimensional, reflecting complex pathological processes and causal pathways, requiring multivariate techniques to disentangle. Furthermore, little is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Introduction: Multiple object tracking (MOT) is a powerful paradigm for measuring sustained attention. Although previous fMRI studies have delineated the brain activation patterns associated with tracking and documented ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
Heart rate variability (HRV) has become central to biobehavioral models of self-regulation and interpersonal interaction. While research on healthy populations suggests changes in respiratory frequency do not affect ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Background: Attention deficit hyperactivity disorder (ADHD) is a highly heritable neuropsychiatric condition, but it has been difficult to identify genes underlying this disorder. This study aimed to explore genetics of ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects that influence ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Objectives Bipolar disorder (BD) is a highly heritable disorder with polygenic inheritance. Among the most consistent findings from functional magnetic imaging (fMRI) studies are limbic hyperactivation and dorsal hypoactivation. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
Despite the promise of intranasal oxytocin (OT) for modulating social behavior, recent work has provided mixed results. This may relate to suboptimal drug deposition achieved with conventional nasal sprays, inter-individual ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ...