Abstract
Epilepsy is one of the most common chronic neurological disorders affecting more than 50 million people worldwide. The disorder is considered a major health problem with increased risk of mortality and co-morbidities. The lack of a variety of reliable validated epilepsy models could possibly hinder or slow the progress in the discovery of better therapeutic options. The purpose of this study was to try and generate new models for epileptogenesis in zebrafish larvae to improve our understanding of epilepsy and how it develops, and that could be used for the discovery of new treatment options. with better outcome that could possibly prevent epilepsy from developing. A novel epileptic model was induced with valproate, but further studies are needed to validate for future drug discovery and to determine if the seizures are chronic. Epilepsy, zebrafish, epileptic model, seizure, epileptogenesis, models of epilepsy, chronic seizure, valproate, induced seizure, ginkgo biloba, epileptogenic, epileptiform activity, EEG, behavioural tracking, MTC, electrophysiological analysis, novel models, pharmacoresistant epilepsy, mortality, comorbidity