Browsing BioMed Central høstingsarkiv by Author "Pahnke, Jens"

Now showing items 1-5 of 5

  • Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates 
    Mairinger, Severin; Jackwerth, Matthias; Soukup, Ondřej; Blaickner, Matthias; Decristoforo, Clemens; Nics, Lukas; Pahnke, Jens; Hacker, Marcus; Zeitlinger, Markus; Langer, Oliver (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Background 6-Bromo-7-[11C]methylpurine ([11C]BMP) is a radiotracer for positron emission tomography (PET) to measure multidrug resistance-associated protein 1 (MRP1) transport activity in different tissues. ...
  • Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice 
    Steffen, Johannes; Krohn, Markus; Schwitlick, Christina; Brüning, Thomas; Paarmann, Kristin; Pietrzik, Claus U; Biverstål, Henrik; Jansone, Baiba; Langer, Oliver; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts ...
  • HD_BPMDS: a curated binary pattern multitarget dataset of Huntington’s disease–targeting agents 
    Stefan, Sven M.; Pahnke, Jens; Namasivayam, Vigneshwaran (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The discovery of both distinctive lead molecules and novel drug targets is a great challenge in drug discovery, which particularly accounts for orphan diseases. Huntington’s disease (HD) is an orphan, neurodegenerative ...
  • Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice 
    Farfara, Dorit; Sooliman, Meital; Avrahami, Limor; Royal, Tabitha G.; Amram, Shoshik; Rozenstein-Tsalkovich, Lea; Trudler, Dorit; Blanga-Kanfi, Shani; Eldar-Finkelman, Hagit; Pahnke, Jens; Rosenmann, Hanna; Frenkel, Dan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Alzheimer’s disease (AD) is the leading cause of dementia in the world. The pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies. Yet, the direct link ...
  • Revisiting rodent models: Octodon degus as Alzheimer’s disease model? 
    Steffen, Johannes; Krohn, Markus; Paarmann, Kristin; Schwitlick, Christina; Brüning, Thomas; Marreiros, Rita; Müller-Schiffmann, Andreas; Korth, Carsten; Braun, Katharina; Pahnke, Jens (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Alzheimer’s disease primarily occurs as sporadic disease and is accompanied with vast socio-economic problems. The mandatory basic research relies on robust and reliable disease models to overcome increasing incidence and ...