Browsing BioMed Central høstingsarkiv by Author "Page, Christian M"

Now showing items 1-6 of 6

  • A Bayesian mixed modeling approach for estimating heritability 
    Nustad, Haakon E; Page, Christian M; Reiner, Andrew H; Zucknick, Manuela; LeBlanc, Marissa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate ...
  • An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies 
    Haftorn, Kristine L; Lee, Yunsung; Denault, William R P; Page, Christian M; Nustad, Haakon E; Lyle, Robert; Gjessing, Håkon K; Malmberg, Anni; Magnus, Maria C; Næss, Øyvind; Czamara, Darina; Räikkönen, Katri; Lahti, Jari; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be ...
  • Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array 
    Lee, Yunsung; Haftorn, Kristine L; Denault, William R P; Nustad, Haakon E; Page, Christian M; Lyle, Robert; Lee-Ødegård, Sindre; Moen, Gunn-Helen; Prasad, Rashmi B; Groop, Leif C; Sletner, Line; Sommer, Christine; Magnus, Maria C; Gjessing, Håkon K; Harris, Jennifer R; Magnus, Per; Håberg, Siri E; Jugessur, Astanand; Bohlin, Jon (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the ...
  • Cisplatin treatment of testicular cancer patients introduces long-term changes in the epigenome 
    Bucher-Johannessen, Cecilie; Page, Christian M; Haugen, Trine B; Wojewodzic, Marcin W; Fosså, Sophie D; Grotmol, Tom; Haugnes, Hege S; Rounge, Trine B (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Background Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. ...
  • Epigenetics, heritability and longitudinal analysis 
    Nustad, Haakon E; Almeida, Marcio; Canty, Angelo J; LeBlanc, Marissa; Page, Christian M; Melton, Phillip E (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background Longitudinal data and repeated measurements in epigenome-wide association studies (EWAS) provide a rich resource for understanding epigenetics. We summarize 7 analytical approaches to the GAW20 ...
  • Quality control for Illumina 450K methylation data in the absence of iDat files using correlation structure in pedigrees and repeated measures 
    LeBlanc, Marissa; Nustad, Haakon E; Zucknick, Manuela; Page, Christian M (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background An important feature in many genomic studies is quality control and normalization. This is particularly important when analyzing epigenetic data, where the process of obtaining measurements can ...