Browsing Institutt for klinisk medisin by Title
Now showing items 6480-6499 of 10911
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Gynaecological carcinosarcomas are rare biphasic tumours which are highly aggressive. We performed molecular investigations on a series of such tumours arising in the uterus (n = 16) and ovaries (n = 10) to gain more ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Shiga toxin (Stx)-producing Escherichia coli (STEC) is an important foodborne pathogen with the ability to cause bloody diarrhea (BD) and hemolytic uremic syndrome (HUS). Little is known about enterohemolysin-encoded by ...
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(Doctoral thesis / Doktoravhandling, 2010)The acknowledged heterogeneity of breast cancer both at the clinical and at the molecular level has been a challenge in classification of breast cancer. This study aimed at identifying distinct molecular subgroups of the ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Cardiovascular diseases continue to be a leading cause of morbidity and mortality worldwide. Cardiomyocytes, as the elementary heart components, play a crucial role in maintaining a healthy heart by coordinating contractions ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background PARP inhibitors are active in various tumour types beyond BRCA-mutant cancers, but their activity and molecular correlates in colorectal cancer (CRC) are not well studied. Methods Mutations and genome-wide ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Background After total mesorectal excision (TME) for rectal cancer around 10% of patients develops local recurrences within the pelvis. One reason for recurrence might be spillage of cancer cells during ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)The main tools for clinical diagnostics of Lyme neuroborreliosis (LNB) are based on serology, i.e., detection of antibodies in cerebrospinal fluid (CSF). In some cases, PCR may be used as a supplement, e.g., on CSF from ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Breast cancer consists of at least five main molecular “intrinsic” subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Background/Aim: The aim of the study was to determine the genetic and molecular consequences of trisomy 4, a recurrent but rare chromosomal abnormality in acute myeloid leukemia (AML). Materials and Methods: Interphase ...
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(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2014)It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Purpose As atherosclerosis is a prominent cause of morbidity and mortality, early detection of atherosclerotic plaques is vital to prevent complications. Imaging plays a significant role in this goal. Molecular imaging and ...
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(Doctoral thesis / Doktoravhandling, 2013)ErbB proteins are a family of receptor tyrosine kinases that includes epidermal growth factor receptor (EGFR), ErbB2, ErbB3 and ErbB4. ErbB proteins govern many physiological processes during development and in an adult ...
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(Doctoral thesis / Doktoravhandling, 2008)The prevalence of congestive heart failure (CHF) is increasing dramatically world-wide. Sustained myocardial hypertrophy is an important risk factor for developing CHF, but the underlying mechanisms initiating and maintaining ...
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(Doctoral thesis / Doktoravhandling, 2020)Cardiovascular diseases are one of the top causes of mortality worldwide, and the main underlying cause is atherosclerosis. Atherosclerosis is a multifactorial and progressive arterial disease where lipid accumulation and ...
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(Doctoral thesis / Doktoravhandling, 2012)
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(Doctoral thesis / Doktoravhandling, 2009)Lege og forsker Thomas Gero von Lueder har i sitt doktorgradsarbeid funnet nye mekanismer bak hjertesvikt, og identifisert nye potensielle mål for behandling. Forekomsten av hjertesvikt øker betydelig i hele den vestlige ...
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(Doctoral thesis / Doktoravhandling, 2018)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Endometrial stromal sarcomas (ESS) are a heterogeneous group of rare mesenchymal cancers. Considerable knowledge has been gained in recent years about the molecular characteristics of these cancers, which helps to classify ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background An unexplained regional difference in survival was observed in previous publications on outcome for children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor (CNS-PNET) in Norway. ...