Browsing Institutt for klinisk medisin by Title
Now showing items 4777-4796 of 10911
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)Background We describe a patient presenting with central retinal artery occlusion (CRAO) of the right eye after retrobulbar anesthesia with adrenaline for macular pucker surgery. ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background Immunotherapy with checkpoint inhibitors (CPI) targeting PD-1 or CTLA-4 has emerged as an important treatment modality for several cancer forms. In hormone receptor positive breast cancer (HR + BC), this ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)Background Multiple myeloma (MM) cancers originate from plasma cells that have passed through the germinal center reaction where somatic hypermutation of Ig V regions takes place. Myeloma protein V regions often express ...
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(Doctoral thesis / Doktoravhandling, 2009)ATP-binding cassette (ABC) transporters are integral components of most living cells and constitute a large group of structurally related transmembrane proteins. These transporters translocate a wide variety of substrates ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)The genes PRKACA and PRKACB encode the principal catalytic (C) subunits of protein kinase A (PKA) Cα and Cβ, respectively. Cα is expressed in all eukaryotic tissues examined and studies of Cα knockout mice demonstrate a ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)Autoimmune Addison's disease (AAD) is a classic organ-specific autoimmune disease characterized by an immune-mediated attack on the adrenal cortex. As most autoimmune diseases, AAD is believed to be caused by a combination ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background The tumor suppressor pRb plays a key role regulating cell cycle arrest, and disturbances in the RB1 gene have been reported in different cancer forms. However, the literature reports contradictory ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background More accurate risk assessments are needed to improve prostate cancer management. Objective To identify blood-based protein biomarkers that provided prognostic information for risk stratification. Design, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)The ubiquitin-proteasome system (UPS) and macroautophagy/autophagy are the main proteolytic systems in eukaryotic cells for preserving protein homeostasis, i.e., proteostasis. By facilitating the timely destruction of ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)The polymeric Ig receptor (pIgR), also called membrane secretory component (SC), mediates epithelial transcytosis of polymeric immunoglobulins (pIgs). J Chain-containing polymeric IgA (pIgA) and pentameric IgM bind pIgR ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Recurrent chromosomal translocations leading to gene fusion formation have been described in uterine sarcomas, including low-grade endometrial stromal sarcoma (LG-ESS). Involvement of the PHF1 gene in chromosomal rearrangements ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)Background With advances in next generation sequencing technologies and genomic capture techniques, exome sequencing has become a cost-effective approach for mutation detection in genetic diseases. However, ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)To the best of our knowledge, we report the first case of Dietzia species in a patient with endophthalmitis. A 47-year-old man presented to the ophthalmology department with decreased vision, redness, and minimal pain in ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2008)Backgound In scrapie and prion diseases, the knowledge concerning genes involved in host response during the early infection period in the lymphoid tissues, still remains limited. In the present study, we ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders. We examined molecular determinants of ligand binding ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Background Until recently, chromosomal translocations and fusion genes have been an underappreciated class of mutations in solid tumors. Next-generation sequencing technologies provide an opportunity for ...
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(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Importance: Schizophrenia is associated with widespread cognitive impairments. Although cognitive deficits are one of the factors most strongly associated with functional outcome in schizophrenia, current treatment strategies ...